John Hopkins Webinar on transplant recipients and vaccines

Posted by bosco17 @bosco17, Mar 24 6:34am

They said after first shot 17 out of 800+patients had only a minimal antibody reaction .Also being on mycophelonate reduces effect of vaccines.WHATS GOING ON ??????

@estrada53

I hope I added thd link correctly.

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Ellen, here's the direct link to the article

Testing Third Doses of COVID Vaccine in Transplant Patients
— New study offers hope for protecting this vulnerable population from COVID-19
https://www.medpagetoday.com/opinion/second-opinions/93102

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@colleenyoung

Ellen, here's the direct link to the article

Testing Third Doses of COVID Vaccine in Transplant Patients
— New study offers hope for protecting this vulnerable population from COVID-19
https://www.medpagetoday.com/opinion/second-opinions/93102

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Thanks, Colleen.

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@athenalee

Next John Hopkins Webinar on COVID-19 Antibody Testing of Recipients of Solid Organ Transplants (IRB00248540) being led by the transplant team at Johns Hopkins.

1-hour live webinar on Thursday, July 8, 2021, at 1:00PM EDT to share our updated findings and answer questions.

Please register here: https://jhjhm.zoom.us/webinar/register/WN_Pr8grO9lSp2ojJM5mk8OXw

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Thanks, @athenalee for the shingrix info and the webinar info. I just signed up to attend.

I've searched online for any trials that might be available for immunocompromised patients who would be willing to participate by having a third shot but have not been able to find any. With only one person having a negative experience that may or may not be attributed to the third shot, it is sounding very positive.

Mass General's guidelines are basically to continue to do exactly what we have been doing. I can follow that somewhat but not entirely. We are spending a long weekend in Maine with our son, his wife, our daughter, and her husband in July and per MGH I should not come within 6' of them and should be masked when with them. That is not going to happen. I realize there is a slight risk but they are all fully vaccinated so I think the risk is worth it.

MGH will not advise the third shot until it is approved by the CDC so I hope the CDC doesn't take too long. I don't hold out much hope that they will be quick though, we are overall a small segment of the population.
JK

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@contentandwell

Thanks, @athenalee for the shingrix info and the webinar info. I just signed up to attend.

I've searched online for any trials that might be available for immunocompromised patients who would be willing to participate by having a third shot but have not been able to find any. With only one person having a negative experience that may or may not be attributed to the third shot, it is sounding very positive.

Mass General's guidelines are basically to continue to do exactly what we have been doing. I can follow that somewhat but not entirely. We are spending a long weekend in Maine with our son, his wife, our daughter, and her husband in July and per MGH I should not come within 6' of them and should be masked when with them. That is not going to happen. I realize there is a slight risk but they are all fully vaccinated so I think the risk is worth it.

MGH will not advise the third shot until it is approved by the CDC so I hope the CDC doesn't take too long. I don't hold out much hope that they will be quick though, we are overall a small segment of the population.
JK

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Lahey thus far is the same. We should remain vigilant and under the guidance for those not vaccinated.

Here’s an article I read last month about trials in UK, but not necessarily on transplant folks:
https://www.theguardian.com/science/2021/may/19/covid-booster-trial-will-give-third-vaccine-dose-to-uk-volunteers?CMP=Share_iOSApp_Other
This was a story you may have heard: https://www.npr.org/sections/health-shots/2021/06/15/1006382264/a-3rd-dose-of-covid-vaccines-may-boost-immunity-for-transplant-recipients

I imagine the John Hopkins researchers will address it on the upcoming webinar.

Hope you’re enjoying your summer! Athena

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@contentandwell

Thanks, @athenalee for the shingrix info and the webinar info. I just signed up to attend.

I've searched online for any trials that might be available for immunocompromised patients who would be willing to participate by having a third shot but have not been able to find any. With only one person having a negative experience that may or may not be attributed to the third shot, it is sounding very positive.

Mass General's guidelines are basically to continue to do exactly what we have been doing. I can follow that somewhat but not entirely. We are spending a long weekend in Maine with our son, his wife, our daughter, and her husband in July and per MGH I should not come within 6' of them and should be masked when with them. That is not going to happen. I realize there is a slight risk but they are all fully vaccinated so I think the risk is worth it.

MGH will not advise the third shot until it is approved by the CDC so I hope the CDC doesn't take too long. I don't hold out much hope that they will be quick though, we are overall a small segment of the population.
JK

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Oh, I actually just read the research study Colleen had posted. It’s the John Hopkins research group, so that’s good.

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@athenalee

Lahey thus far is the same. We should remain vigilant and under the guidance for those not vaccinated.

Here’s an article I read last month about trials in UK, but not necessarily on transplant folks:
https://www.theguardian.com/science/2021/may/19/covid-booster-trial-will-give-third-vaccine-dose-to-uk-volunteers?CMP=Share_iOSApp_Other
This was a story you may have heard: https://www.npr.org/sections/health-shots/2021/06/15/1006382264/a-3rd-dose-of-covid-vaccines-may-boost-immunity-for-transplant-recipients

I imagine the John Hopkins researchers will address it on the upcoming webinar.

Hope you’re enjoying your summer! Athena

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@athenalee I have read that they are giving transplant patients the third shot already in Europe. So far there does not appear to be a downside to it so I hope it will be approved soon. Of course the downside to not getting it is that we are vulnerable. I wish I was more comfortable in my antibody rating of 13.83 but I'm not sure how much protection that provides.
JK

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@contentandwell

@athenalee I have read that they are giving transplant patients the third shot already in Europe. So far there does not appear to be a downside to it so I hope it will be approved soon. Of course the downside to not getting it is that we are vulnerable. I wish I was more comfortable in my antibody rating of 13.83 but I'm not sure how much protection that provides.
JK

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Thanks for the updates. I wonder what antibody levels are considered a good, protective response?
Just came across this Canadian study of 120 participants which is happening now and hopefully will add something helpful.
https://clinicaltrials.gov/ct2/show/NCT04885907
-NB

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@contentandwell

@athenalee I have read that they are giving transplant patients the third shot already in Europe. So far there does not appear to be a downside to it so I hope it will be approved soon. Of course the downside to not getting it is that we are vulnerable. I wish I was more comfortable in my antibody rating of 13.83 but I'm not sure how much protection that provides.
JK

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I took two Moderna shots and had Zero antibodies, after taking he third shot I do have antibodies. After my 4th shot I will have the lab measure exactly how much antibody protection I have. I should know in 4 weeks.

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@benlam11

I took two Moderna shots and had Zero antibodies, after taking he third shot I do have antibodies. After my 4th shot I will have the lab measure exactly how much antibody protection I have. I should know in 4 weeks.

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For the benefit of the rest of us with two shots, the transplant community through the Transplant Surgeons and FDA are not recommending a 3rd or 4th shot. It's on their website. But my question is, are you working with you GP or local doc to get the shots or just scheduling an appt with a vac center? And is any of this covered by insurance or is it an out of pocket? Thanks.

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@joko

For the benefit of the rest of us with two shots, the transplant community through the Transplant Surgeons and FDA are not recommending a 3rd or 4th shot. It's on their website. But my question is, are you working with you GP or local doc to get the shots or just scheduling an appt with a vac center? And is any of this covered by insurance or is it an out of pocket? Thanks.

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As I looked at the Johns Hopkins study, 30% of the study participants received immunity after the 3rd shot. Additionally France now approved a third shot for compromised patients. I did let my doctors know ( MAYO and local ) that I was planning a third shot. None would recommend it, however I thought it was worth the risk. I just went to my local pharmacy – asked for a shot – and it was given, no charge, no questions asked. My next shot is next week and two weeks after that my local Doctor will run the test to see how much antibody I have. None of this is recommended by any Doctor nor U.S. agency. I just thought it was worth the risk for myself, as locally the Delta variant is concerning and at a nearby hospital the number of Covid patient went from 8 to 20 ( all unvaccinated ) in one week. Hope this helps.

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@benlam11

As I looked at the Johns Hopkins study, 30% of the study participants received immunity after the 3rd shot. Additionally France now approved a third shot for compromised patients. I did let my doctors know ( MAYO and local ) that I was planning a third shot. None would recommend it, however I thought it was worth the risk. I just went to my local pharmacy – asked for a shot – and it was given, no charge, no questions asked. My next shot is next week and two weeks after that my local Doctor will run the test to see how much antibody I have. None of this is recommended by any Doctor nor U.S. agency. I just thought it was worth the risk for myself, as locally the Delta variant is concerning and at a nearby hospital the number of Covid patient went from 8 to 20 ( all unvaccinated ) in one week. Hope this helps.

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Excellent information. Thanks. I have recommended the JH and French study to others. Let us know how it works out. Wish you the best. You're conducting your own private research study.

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@benlam11

As I looked at the Johns Hopkins study, 30% of the study participants received immunity after the 3rd shot. Additionally France now approved a third shot for compromised patients. I did let my doctors know ( MAYO and local ) that I was planning a third shot. None would recommend it, however I thought it was worth the risk. I just went to my local pharmacy – asked for a shot – and it was given, no charge, no questions asked. My next shot is next week and two weeks after that my local Doctor will run the test to see how much antibody I have. None of this is recommended by any Doctor nor U.S. agency. I just thought it was worth the risk for myself, as locally the Delta variant is concerning and at a nearby hospital the number of Covid patient went from 8 to 20 ( all unvaccinated ) in one week. Hope this helps.

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@benlam11 I was about to ask you the same question. This is the first I have heard of a 4th shot, I would be happy to get the third one but since it is against the advice of my hospital I wonder what it might do to my standing there.
As I have mentioned before, I do have some immunity, I just don't know how much protection my number provides. I am very tempted to get a third one myself but for now I will wait. The Delta variant is very concerning though.
JK

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