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HOCM & 8th month on Camzyos...how long will Camzyos work?
My HOCM became obstructive at the beginning of 2025. Started Camzyos shortly after. Now 8 months on it. Whenever I have stress, chest aches. Working at meditation. I wonder what the statistical likelihood is that I can take Camzyos for many years or for life (or what's left of it---I'm around 60 and also have cancer and apparently a small brain tumor they just found among many other medical problems) and be ok and never need surgery or have other heart problems connected to this.
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Can someone take Camzyos for many years or even for life?
Yes — many people with obstructive HCM can stay on Camzyos long-term, and current evidence shows it can be used for years, safely, as long as the required monitoring is followed.
But whether it ends up being “for life” depends on the person’s heart and how they respond.
Here's what is known:
Camzyos (mavacamten) has 3+ years of follow-up data from extension studies, and results show:
It continues to reduce obstruction.
It improves symptoms, exercise capacity, and quality of life.
Its effects remain stable over time for most people.
Some patients stay on it continuously.
Others pause or stop if:
Their left ventricular ejection fraction (LVEF) drops too low.
Their obstruction improves so much that symptoms become minimal.
They need another therapy (like myectomy, alcohol septal ablation, or another medication).
Is it intended as a lifelong therapy?
Camzyos is potentially a long-term or lifelong medication, if:
It keeps working well.
The heart stays safe on it.
The patient still needs obstruction control.
But it’s not automatic that every patient will stay on it forever.
Key point: Monitoring is essential.
Because Camzyos affects heart muscle contractility, patients must get:
Regular echocardiograms (monthly at first, then every 3–6 months)
Dose adjustments based on ejection fraction and LVOT gradient
This is what makes long-term use safe.
Bottom line
✔ Yes, Camzyos can be taken for many years.
✔ Some will stay on it indefinitely.
✔ Others may reduce, pause, or discontinue depending on heart changes.
✔ Long-term safety looks good so far with proper monitoring.
The above information is from an authentic study on Camzyos.
I just got off Camzyos 4 weeks ago with being on it for 1 year and 8 months. It great in reducing my HOCM symptoms and allowed me to walk with more exertion. I still though had ongoing symptoms with activity. At 54 I have decided to go through Septal Myectomy surgery at Mayo to get closer to a normal state. After 3 weeks of stopping Camzyos my obstruction came back STRONG with breathing and chest pain while walking and more so when exerting. My cardiologist maxed my Bystolic to help, which it has but I still have symptoms both not the strong chest pain of earlier.
So Camzyos worked but I was concerned with staying on it long-term and the ongoing need for medication monitoring and adjustments. Considering surgery is a big step but feel getting it done at my age will be worth it. Good luck and hope everything goes well.