Eliquis and muscle pain

@chanemann1 just read side effects of eliquis

@charley7wills They did change me to Xarelto and it was worse than Eliquis. 30 days of that and back on Eliquis. Thankfully they think or hope the blood clot has dissolved and for the last ten days I have been on one aspirin a day. Much Much better. My knees still have stiffness and other areas still have symptom's but getting better eveyday. I don't ever want to have to take either of those again. Hoping when I have the other knee replaced I don't get a blood clot.

@lgirl
Yes, I won’t ever take either one of them again! Ask your doctor before your other knee if they can give you the injections for your blood thinner. That is what I got for my broken ankle and it needed surgery and a month in physical rehab so the risk for clots might be comparable. You probably won’t be in a medical setting for that amount of time, so it could depend on you being able to self-administer or having someone inject you, but it is a relatively small injection that goes into a fatty spot like your abdomen.

@lgirl the name of the medication is Lovenox.

@abob No, I have taken CoQ10 throughout my time on Xarelto and Eliquis. If the CoQ10 mitigated the pain from the other 2, I can’t imagine what the pain would have been without it.

I'm 75. Five minutes of activity and I'm feeling pain in both upper trapezius muscles (those running down from the back of the neck toward each shoulder). Twenty minutes pushing a cart in a supermarket and I can barely hold my head up: I'm lucky the pain/cramping slowly disappears while seating in my car's bucket seat. Also, if I get up from a seat quickly, I sometimes feel lightheaded for about 15 seconds.
I'm taking Eliquis to thin blood, Carvedilol to keep my heart slow, and Lasix as a diuretic and some other meds to address potassium (now back to normal level), iron, and type-II diabetes.
I was diagnosed with heart A-fib in mid-Dec. 2025, weak heart atriums pumping 50% of the normal blood amount at rest (30% of max.). I also developed extreme weakness in my muscles after losing 30 lb in a year, then losing 30 more in a month due to Lasix with little exercise.
Strength physical therapy began in Feb. and with be completed May 7th. My legs and arms regained strength - I can stand up from sitting on a floor without needing anything vertical to help me stand.
The A-fib was gone by the end of Dec. with normal sinus rhythm in the heart ever since.
Another Cardiac Echo Test on Mar. 24th showed my heart atriums are pumping 75% of the normal blood amount at rest (40-45 of max when 50% would be considered ok and 60% is normal).
My cardiologist cut the Lasix in half but doesn't want to reduce the other meds ("why mess with success") until he evaluates my next Cardiac Echo test on Aug. 19th.
But the trapezius muscles still hurt, even after almost 2 months of PT that exercises and massages them, when I'm starting coffee and nuking breakfast in the morning, picking up objects, etc. So I'm investigating the effects of the meds,

@mickinmd

After a heart attack I was given amiodarone and statins. I exercise for an hour or so almost every day, and I began to experience pain and weakness in my legs and arms. I had to keep up the exercise routine, so I put up with it.

Recently I have been given Jardiance and Eliquis. I no longer take statins or amiodarone. My cholesterol is normal.

I still experience pain and weakness, but subjectively it is a lot less than before. My legs are still a bit weak, but I was told that was to be expected with heart failure, low ejection fraction, and age. Most importantly I am still able to use my treadmill, lift light weights, and free exercise. I'm content with that.

@debmonroe

I saw a new cardiologist today from a different healthcare system. I only take eliquis after one incident 16 months ago. He asked why I want off of Eliquis..I said muscle pain and stiffness, joint pain and I may not even need it. He said nope, cannot be from the eliquis. I figured that would happen so blew it off. He also told me that I have A Flutter, not Afib so that's new. I told him I felt it distinctly but he said data shows many who think they feel every incident proves them wrong. I will accept that. Referred for a 14 day Holter monitor and to a virtual visit with an EP before he will support dropping it, but will now be the EPs decision so follow up in 4 months with a nurse practitioner. Guess I won't be seeing him again? Weird.

@moski I had the same experience. One dose and I could not sleep, had to pee every hour, and had legs too weak to walk (even at home), GI problems galore, dizzy, life ending thoughts, and it took weeks to get a bit back to normal.
After 1 day of taking Eliquis.
I stopped my doses after 24 hours, after taking 5mg Eliquis two times that first 24 hours.
5 weeks later and the pain in my joints and musles is so bad that I can not live like this.
Thankfully, my specialist suggested upping my doses of transdermal bio-identical oestrogen to 4 'pumps' (instead of the 3 pumps) to combat the joint/muscle pain.
And that indeed helps.
I am waiting for the full effect of Eliquis to leave my body.
I really do hope it does not take me months to lose all the effects of Eliquis!