Eliquis and muscle pain

Posted by rice @rice, Dec 29, 2025

Has anyone had muscle pain in the back and legs while on Eliquis? If so could you describe the pain and location?

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Profile picture for chanemann1 @chanemann1

@carly14 COULD YOU GIVE THE INFORMATION WHERE
YOU READ THAT ELIQUIS CREATES MUSCLE WEAKNESS IN THE LEGS?

THANK YOU

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@chanemann1 just read side effects of eliquis

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Profile picture for charley7wills @charley7wills

@lgirl
Make sure they don’t switch you to Xarelto. I was switched to Eliquis from Xarelto because the pain was even worse on Xarelto. I couldn’t even turn my head on it. Eliquis just changed the location of my pain. I have huge difficulty using my hands and have signs of Duyptens contracture after only 3 months.

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@charley7wills They did change me to Xarelto and it was worse than Eliquis. 30 days of that and back on Eliquis. Thankfully they think or hope the blood clot has dissolved and for the last ten days I have been on one aspirin a day. Much Much better. My knees still have stiffness and other areas still have symptom's but getting better eveyday. I don't ever want to have to take either of those again. Hoping when I have the other knee replaced I don't get a blood clot.

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Profile picture for lgirl @lgirl

@charley7wills They did change me to Xarelto and it was worse than Eliquis. 30 days of that and back on Eliquis. Thankfully they think or hope the blood clot has dissolved and for the last ten days I have been on one aspirin a day. Much Much better. My knees still have stiffness and other areas still have symptom's but getting better eveyday. I don't ever want to have to take either of those again. Hoping when I have the other knee replaced I don't get a blood clot.

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@lgirl
Yes, I won’t ever take either one of them again! Ask your doctor before your other knee if they can give you the injections for your blood thinner. That is what I got for my broken ankle and it needed surgery and a month in physical rehab so the risk for clots might be comparable. You probably won’t be in a medical setting for that amount of time, so it could depend on you being able to self-administer or having someone inject you, but it is a relatively small injection that goes into a fatty spot like your abdomen.

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Profile picture for lgirl @lgirl

@charley7wills They did change me to Xarelto and it was worse than Eliquis. 30 days of that and back on Eliquis. Thankfully they think or hope the blood clot has dissolved and for the last ten days I have been on one aspirin a day. Much Much better. My knees still have stiffness and other areas still have symptom's but getting better eveyday. I don't ever want to have to take either of those again. Hoping when I have the other knee replaced I don't get a blood clot.

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@lgirl the name of the medication is Lovenox.

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Profile picture for abob @abob

I had leg pains from Atorvastatin. I started taking COQ10 and the pains are gone. Don’t know if this is helpful for Eliquis.

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@abob No, I have taken CoQ10 throughout my time on Xarelto and Eliquis. If the CoQ10 mitigated the pain from the other 2, I can’t imagine what the pain would have been without it.

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