MTHFR mutation and supplements to take

Posted by contilucy1960 @contilucy1960, Aug 27, 2021

I have been taking up to 11 vitamins and supplements a day as prescribed by a doctor 7 years ago, due to MTHFR gene mutation. I would like to update what supplements and vitamins are needed for this condition. Any input welcome!

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What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

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Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

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@contilucy1960

What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

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Thank you very much for the pointers, I will check them out!

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@amandaa

Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

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Thank you so much for your response! I do eat pasta, but it is usually brown rice pasta and I try to eat only organic whole grains (like WASA rye crackers). I do not usually eat refined foods and I try to avoid sugar. What I don’t know is whether I need to stay on ALL those supplements.

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Is it necessary to take supplements if you are positive for one copy of the A1298c variant and normal for the c677t? So confusing. Dr just brushes it off as she did when she diagnosed me w hashimotos and said not to change my diet without even knowing my diet. Needless to say I was fired!

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@erinsbee

Is it necessary to take supplements if you are positive for one copy of the A1298c variant and normal for the c677t? So confusing. Dr just brushes it off as she did when she diagnosed me w hashimotos and said not to change my diet without even knowing my diet. Needless to say I was fired!

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hi Erin, welcome. There’s limited research regarding the variant A1298C. Available studies are generally geographically or ethnic-based. But you might find this article of help regarding supplements and diet for people with the MTHFR gene:
– What You Need to Know About the MTHFR Gene https://www.healthline.com/health/mthfr-gene

I'd like to bring fellow members @contilucy1960 @bet @grammanancy @forestguide @blendedmom @courage3512 @lilli64 @msfxit @diannelk @monk1015 into this discussion. They may have more experiences with diet, supplements and the MTHFR gene to share with you.

Erin, do you take any supplements at the moment?

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Thank you for adding me. I hope to learn more about how to handle MTHFR gene diagnosis

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@colleenyoung

hi Erin, welcome. There’s limited research regarding the variant A1298C. Available studies are generally geographically or ethnic-based. But you might find this article of help regarding supplements and diet for people with the MTHFR gene:
– What You Need to Know About the MTHFR Gene https://www.healthline.com/health/mthfr-gene

I'd like to bring fellow members @contilucy1960 @bet @grammanancy @forestguide @blendedmom @courage3512 @lilli64 @msfxit @diannelk @monk1015 into this discussion. They may have more experiences with diet, supplements and the MTHFR gene to share with you.

Erin, do you take any supplements at the moment?

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I WAS taking pure encapsulated methyl assist. I Am taking D3 selenium, life extension 2 a day multi vitamin plus armour and levothytoxine for hypo thyroid. I have hashimotos and did a test through fm testing and it came back 96% positive for fibromyalgia. My sed rate is 30. Got that result back today. Rheumatoid dr is going to see me in January for that. Sore shoulders. Like fire! Possible polymyalgia rheumatica. Diagnosed myself til dr can see me. I hope cortisteroids will relieve my pain but worry about bone loss. Already had three bone density scans and I have osteopenia in back. Thanks for the help. I need it

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There is some related information on MedlinePlus Genetics site that might be helpful.

"Normal Function – The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving the vitamin folate (also called vitamin B9). Specifically, this enzyme converts a form of folate called 5,10-methylenetetrahydrofolate to a different form of folate called 5-methyltetrahydrofolate. This is the primary form of folate found in blood, and is necessary for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds."
— MTHFR gene: https://medlineplus.gov/genetics/gene/mthfr/

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@amandaa

Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

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I have tested positive for being double heterozygous for the MTHFR gene mutation. I can't find much info on this particular mutation combination, but I have been taking 3,000mcg of l-methylfolate and wonder if I should be taking more. I suffer from depression and anxiety, fibromyalgia and various muscle aches and pains.

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Hello,

I am MTHFR (blood test level confirmed low Folate and DNA test), have high Ragweed Allergy (blood test confirmed) and Composite Mix II allergy skin test confirmed (I am unable to include links in my post as I am new here, but the information as to what this all means is below the the line____)

So I am limited to trying to eat certain things now… I was eating a lot of bananas and mangos, my favorite, including lettuce. The issue is that these things are all on my allergy list one way or another.

Is there a supplement that you would recommend? I take a lot individually, but that gets so expensive. A mayo doc suggested I cut back on all my supplements, which was strange as the only reason that I do this is because I have not found a solution in a multivitamin? That doc also said, "I have never met anyone with confirmed MTHFR". So I did not take her suggestion seriously. The mayo allergy immunotherapy docs spent less than 5 mins looking at my file, they never contacted me to discuss or look into things further… I was astounded and literally disgusted by their lack of help. I had to have additional testing with HealthPartners to figure out why I always feel sick.

I suffer from year-round stuffiness and eye itching. I am now on Zyrtec, Pepcid, Allegra, Singular, Flonase, Alaway, NasalCrom, and other medicines. These are just my allergy-specific ones.

High Prolactin, ADHD, and have an 8cm Bosniak 2F on my left Kidney. So I am trying to stay as healthy as possible.
_________________________________________________________________________________________________________
What are symptoms of ragweed allergies?
Like all pollen allergies, allergies to ragweed can lead to allergic rhinitis (hay fever), inflammation of the nasal passages.

Ragweed allergy symptoms are:
Nasal congestion
Runny nose with thin, water discharge
Postnasal drip
Sneezing
Coughing
Watery, itchy or irritated eyes
Eye swelling – the “allergic shiner”
Weakness or fatigue
Hives on the skin

What foods are related to ragweed?
You may need to avoid certain fruits and vegetables if you re allergic to ragweed and develop symptoms from eating these foods. This happens because foods botanically related to ragweed can trigger what is known as oral allergy syndrome (OAS).

Foods in the ragweed family include:
artichoke
banana
chamomile
cucumber
echinacea
mango
melon (watermelon, cantaloupe, honeydew)
sunflower seed
zucchini
__________________________________________________________________________________________________________
Complete list of categories in the Compositae Family:
Skin contact with Compositae Mix is required for it to cause a rash. Discontinuation of exposure to products containing Compositae Mix should result in improvement and/or resolution of your dermatitis. By law, all products made in the US for topical use have the ingredients listed either on the product package or the box that contains it, so check the labeling of your skin care products for this ingredient. If there is no information ask your pharmacist or call the company directly. At work, request a material safety data sheet (MSDS) to help identify potential sources of exposure. Personal care products that are label “botanical” may contain one of the ingredients of the Compositae mix.
African daisy
Arnica
Artichoke, globe
Artichoke, wild
Aster
Bitterweed
Boneset
Broomweed
Calendula
Capeweed
Chamomile, German
Chamomile, Roman
Chicory
Chickweed
Chrysanthemum
Cocklebur
Costus of perfumery
Cotton thistle
Dandelion
Elecampane
Encelia
Endive
Fireweed
Fleabane
Gayule
Groundsel
Hampweed
Helianthus
Hodweed
Inula
Ironweed
Laurel oil
Leafcup
Lettuce
Liverwort
Marguerite
Marigold
Marsh elder
Mugwort
Mutisia
Oxeye
Parthenium
Pyrethrum
Ragweed
Ragwort
Sagebrush
Sneezeweed
Sow thistle
Star thistle
Stinkwort
Sunflower
Tansy
Tulip tree
Whitewood of commerce
Wormwood
Yarrow

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@contilucy1960

What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

Jump to this post

Hi @contilucy1960

My sister -in-law also has the MTHFR gene mutation and we were just talking about this question of know what to take this morning. I can confidently share with you that you can learn for yourself precisely what is right for you and for your body. How?

I teach every client self-muscle testing! This tool gives you the ability to listen to your body to know what is right for you. Everyone is different!

I don't tell my clients what to take. Rather I teach them how to do self-muscle testing and then give them a list of options and they find out what is right by listening to their body.

Everyone can learn how to self-muscle test. I and my clients use it every day for supplements, for food and for getting their best wellness.

Take care, Fred at The Wholesome Life.

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