MTHFR mutation and supplements to take

Posted by contilucy1960 @contilucy1960, Aug 27, 2021

I have been taking up to 11 vitamins and supplements a day as prescribed by a doctor 7 years ago, due to MTHFR gene mutation. I would like to update what supplements and vitamins are needed for this condition. Any input welcome!

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What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

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Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

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@contilucy1960

What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

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Thank you very much for the pointers, I will check them out!

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@amandaburnett

Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

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Thank you so much for your response! I do eat pasta, but it is usually brown rice pasta and I try to eat only organic whole grains (like WASA rye crackers). I do not usually eat refined foods and I try to avoid sugar. What I don’t know is whether I need to stay on ALL those supplements.

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Is it necessary to take supplements if you are positive for one copy of the A1298c variant and normal for the c677t? So confusing. Dr just brushes it off as she did when she diagnosed me w hashimotos and said not to change my diet without even knowing my diet. Needless to say I was fired!

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@erinsbee

Is it necessary to take supplements if you are positive for one copy of the A1298c variant and normal for the c677t? So confusing. Dr just brushes it off as she did when she diagnosed me w hashimotos and said not to change my diet without even knowing my diet. Needless to say I was fired!

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hi Erin, welcome. There’s limited research regarding the variant A1298C. Available studies are generally geographically or ethnic-based. But you might find this article of help regarding supplements and diet for people with the MTHFR gene:
– What You Need to Know About the MTHFR Gene https://www.healthline.com/health/mthfr-gene

I'd like to bring fellow members @contilucy1960 @bet @grammanancy @forestguide @blendedmom @courage3512 @lilli64 @msfxit @diannelk @monk1015 into this discussion. They may have more experiences with diet, supplements and the MTHFR gene to share with you.

Erin, do you take any supplements at the moment?

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Thank you for adding me. I hope to learn more about how to handle MTHFR gene diagnosis

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@colleenyoung

hi Erin, welcome. There’s limited research regarding the variant A1298C. Available studies are generally geographically or ethnic-based. But you might find this article of help regarding supplements and diet for people with the MTHFR gene:
– What You Need to Know About the MTHFR Gene https://www.healthline.com/health/mthfr-gene

I'd like to bring fellow members @contilucy1960 @bet @grammanancy @forestguide @blendedmom @courage3512 @lilli64 @msfxit @diannelk @monk1015 into this discussion. They may have more experiences with diet, supplements and the MTHFR gene to share with you.

Erin, do you take any supplements at the moment?

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I WAS taking pure encapsulated methyl assist. I Am taking D3 selenium, life extension 2 a day multi vitamin plus armour and levothytoxine for hypo thyroid. I have hashimotos and did a test through fm testing and it came back 96% positive for fibromyalgia. My sed rate is 30. Got that result back today. Rheumatoid dr is going to see me in January for that. Sore shoulders. Like fire! Possible polymyalgia rheumatica. Diagnosed myself til dr can see me. I hope cortisteroids will relieve my pain but worry about bone loss. Already had three bone density scans and I have osteopenia in back. Thanks for the help. I need it

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