What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

Hi @contilucy1960

Glad you are trying to stay on top of your MTHFR with added supplements. I am not entirely sure of all the supplements that you need to be taking, but here are some sites that may give some insight.

MTHFR Diet, Lifestyle, & Supplements: https://www.cleaneatingkitchen.com/mthfr-diet-lifestyle-supplements/

What You Need to Know About the MTHFR Gene: https://www.healthline.com/health/mthfr-gene

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html

Are you also trying to avoid harmful foods with this mutation such as enriched grains, like pasta, cereals, breads, and commercially produced flours?

Is it necessary to take supplements if you are positive for one copy of the A1298c variant and normal for the c677t? So confusing. Dr just brushes it off as she did when she diagnosed me w hashimotos and said not to change my diet without even knowing my diet. Needless to say I was fired!

Thank you for adding me. I hope to learn more about how to handle MTHFR gene diagnosis

There is some related information on MedlinePlus Genetics site that might be helpful.

"Normal Function - The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving the vitamin folate (also called vitamin B9). Specifically, this enzyme converts a form of folate called 5,10-methylenetetrahydrofolate to a different form of folate called 5-methyltetrahydrofolate. This is the primary form of folate found in blood, and is necessary for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds."
-- MTHFR gene: https://medlineplus.gov/genetics/gene/mthfr/

Hello,

I am MTHFR (blood test level confirmed low Folate and DNA test), have high Ragweed Allergy (blood test confirmed) and Composite Mix II allergy skin test confirmed (I am unable to include links in my post as I am new here, but the information as to what this all means is below the the line____)

So I am limited to trying to eat certain things now... I was eating a lot of bananas and mangos, my favorite, including lettuce. The issue is that these things are all on my allergy list one way or another.

Is there a supplement that you would recommend? I take a lot individually, but that gets so expensive. A mayo doc suggested I cut back on all my supplements, which was strange as the only reason that I do this is because I have not found a solution in a multivitamin? That doc also said, "I have never met anyone with confirmed MTHFR". So I did not take her suggestion seriously. The mayo allergy immunotherapy docs spent less than 5 mins looking at my file, they never contacted me to discuss or look into things further... I was astounded and literally disgusted by their lack of help. I had to have additional testing with HealthPartners to figure out why I always feel sick.

I suffer from year-round stuffiness and eye itching. I am now on Zyrtec, Pepcid, Allegra, Singular, Flonase, Alaway, NasalCrom, and other medicines. These are just my allergy-specific ones.

High Prolactin, ADHD, and have an 8cm Bosniak 2F on my left Kidney. So I am trying to stay as healthy as possible.
_________________________________________________________________________________________________________
What are symptoms of ragweed allergies?
Like all pollen allergies, allergies to ragweed can lead to allergic rhinitis (hay fever), inflammation of the nasal passages.

Ragweed allergy symptoms are:
Nasal congestion
Runny nose with thin, water discharge
Postnasal drip
Sneezing
Coughing
Watery, itchy or irritated eyes
Eye swelling – the “allergic shiner”
Weakness or fatigue
Hives on the skin

What foods are related to ragweed?
You may need to avoid certain fruits and vegetables if you re allergic to ragweed and develop symptoms from eating these foods. This happens because foods botanically related to ragweed can trigger what is known as oral allergy syndrome (OAS).

Foods in the ragweed family include:
artichoke
banana
chamomile
cucumber
echinacea
mango
melon (watermelon, cantaloupe, honeydew)
sunflower seed
zucchini
__________________________________________________________________________________________________________
Complete list of categories in the Compositae Family:
Skin contact with Compositae Mix is required for it to cause a rash. Discontinuation of exposure to products containing Compositae Mix should result in improvement and/or resolution of your dermatitis. By law, all products made in the US for topical use have the ingredients listed either on the product package or the box that contains it, so check the labeling of your skin care products for this ingredient. If there is no information ask your pharmacist or call the company directly. At work, request a material safety data sheet (MSDS) to help identify potential sources of exposure. Personal care products that are label “botanical” may contain one of the ingredients of the Compositae mix.
African daisy
Arnica
Artichoke, globe
Artichoke, wild
Aster
Bitterweed
Boneset
Broomweed
Calendula
Capeweed
Chamomile, German
Chamomile, Roman
Chicory
Chickweed
Chrysanthemum
Cocklebur
Costus of perfumery
Cotton thistle
Dandelion
Elecampane
Encelia
Endive
Fireweed
Fleabane
Gayule
Groundsel
Hampweed
Helianthus
Hodweed
Inula
Ironweed
Laurel oil
Leafcup
Lettuce
Liverwort
Marguerite
Marigold
Marsh elder
Mugwort
Mutisia
Oxeye
Parthenium
Pyrethrum
Ragweed
Ragwort
Sagebrush
Sneezeweed
Sow thistle
Star thistle
Stinkwort
Sunflower
Tansy
Tulip tree
Whitewood of commerce
Wormwood
Yarrow

I am compound heterozygous (heterozygous for each of c677t and A1298c), and have my share of symptoms, although nothing compared to homozygous c677t sufferers (mostly anxiety and energy in my case). I find there's a lot of bad information on the web, and am relying now on the Dirty Genes book by Dr. Ben Lynch, notably for which supplements to take and how to use them. I dislike his somewhat bombastic writing style, but he seems to be the only one I've found with accurate and thorough medical info. You have to be careful with supplementation for MTHFR; the wrong B vitamins (especially the wrong folate) can make matters worse, as can the wrong dosage, although I've found that dosages are something I have to arrive at by careful trial and error. Hope that helps. - Mitch G

Does anyone know what natural herbs and or oils to use? I’m type 2 diabetic and feel bad all the time and depressed.
MTHFR is the short name for it, even tho the short name seems WRONG! Thanks

I think it's methyl B complex. I had a great chewable from Amazon called EZ Melts I used to take. I have the MTHFR gene too.

In addition to Heterozygous MTHFR C677T, I have Sjogren's Disease. I am specifically concerned about the connection to non-Hodgkins Lymphoma, of which my father died at the age of 41. Additionally, my mother died of Ovarian cancer (age 67), paternal aunt from Breast Cancer, age 66, brother from Liver cancer age 61, other brother survived prostate cancer.
I have gluten allergy, lactose intolerance, osteoporosis, high cholesterol (313, being treated with Simvastatin and Ezetimibe).
I do take supplements and jog 7 miles a day.
I am 5' and weigh 99 lbs.
Female , Age 70
Throughout my life, I have had repeated re-occurrences of laryngitis which turn into pneumonia.
With Sjogrens and Heterozygous MTHFR C677T, what should I be doing to stay healthy, especially in the winter months.
The Sjogrens has exacerbated causing wacko temperature swings and I often go from feeling freezing cold to burning hot within minutes.
I try to stay away from anyone sick as these auto-immune diseases wipe me out when triggered.