MTHFR Mutation

Hay
When I first found out my mthfr0677TT, 70 percent inability to absorb folic acid, I learned a lot from the book Dirty Genes. I now read medical articles and research to see what role the gene mutation has contributed to all my other medical issues. They all are interconnect. Usually people take methylfolate and methylcobaline typo spelling and B6. B vitamins are water soluble, however b6 you can become toxic on. It’s in everything sport drinks, good, Rx , complex supplements, even in magnesium. Thus is what I get tested for : B12 and Homosyteine, and MMA( methalomonic acid) , folate serum, and B6. With the 0677TT your folate and b12 only show what is in your blood stream. Since the mutation is about your inability to absorb, you need to test homosystein levels and MMA to gain better accuracy of how much you are absorbing. Everyone ideal levels are different. Usually people with MtHFR double copy it’s noted that homocysteine levels stay around 7. When mine go to 14 I know I’m deficient in my folate and b12. It’s been tricky for me to fine my right dosing and blood levels. Most doctors are clueless about reading levels in mthfr. I have neuropathy bc I was told my b12 levels were fine. Now I understand why they were actually very low. MtHFR can indirectly effect thyroid as well. when my folate and b12 get out of balance, my thyroid acts up more toward hypo. Now I’m looking into autoimmune thyroid issue. MtHFR has also contributed to my iron deficiency and low platelets and low Ferritin. I get iron infusions and so I also have to get those labs tested. . Be mindful of all medications and OTC that deplete folate and b12. I have to look up everything before taking. Stay away from FOLIC ACID. 0677Tt can not absorb it causing it to float around in your blood stream unused causing more issues. Read labels on foods drinks, otc to avoid folic acid. Only take methyl folate formula. FYI: its helpful to type in my gene mutation and ask google for research articles effecting each medical issue I’m having. Very insightful and helpful to show my doctors. Best wishes.
We all have good and bad genes. Genes get turn on and off according to so many factors we are exposed to. Supplementing manages the MtHFR gene. But many factors can throw it out of wack. Stress, surgeries, medications, lifestyle, diet. Etc. Hope some of this helps.
The Dirty Gene book was helpful to see what to test for and more. Easy reading.
Blessing to you

Hay
When I first found out my mthfr0677TT, 70 percent inability to absorb folic acid, I learned a lot from the book Dirty Genes. I now read medical articles and research to see what role the gene mutation has contributed to all my other medical issues. They all are interconnect. Usually people take methylfolate and methylcobaline typo spelling and B6. B vitamins are water soluble, however b6 you can become toxic on. It’s in everything sport drinks, good, Rx , complex supplements, even in magnesium. Thus is what I get tested for : B12 and Homosyteine, and MMA( methalomonic acid) , folate serum, and B6. With the 0677TT your folate and b12 only show what is in your blood stream. Since the mutation is about your inability to absorb, you need to test homosystein levels and MMA to gain better accuracy of how much you are absorbing. Everyone ideal levels are different. Usually people with MtHFR double copy it’s noted that homocysteine levels stay around 7. When mine go to 14 I know I’m deficient in my folate and b12. It’s been tricky for me to fine my right dosing and blood levels. Most doctors are clueless about reading levels in mthfr. I have neuropathy bc I was told my b12 levels were fine. Now I understand why they were actually very low. MtHFR can indirectly effect thyroid as well. when my folate and b12 get out of balance, my thyroid acts up more toward hypo. Now I’m looking into autoimmune thyroid issue. MtHFR has also contributed to my iron deficiency and low platelets and low Ferritin. I get iron infusions and so I also have to get those labs tested. . Be mindful of all medications and OTC that deplete folate and b12. I have to look up everything before taking. Stay away from FOLIC ACID. 0677Tt can not absorb it causing it to float around in your blood stream unused causing more issues. Read labels on foods drinks, otc to avoid folic acid. Only take methyl folate formula. FYI: its helpful to type in my gene mutation and ask google for research articles effecting each medical issue I’m having. Very insightful and helpful to show my doctors. Best wishes.
We all have good and bad genes. Genes get turn on and off according to so many factors we are exposed to. Supplementing manages the MtHFR gene. But many factors can throw it out of wack. Stress, surgeries, medications, lifestyle, diet. Etc. Hope some of this helps.
The Dirty Gene book was helpful to see what to test for and more. Easy reading.
Blessing to you

What type of doctor do you see for this? I see an integrative medicine MD, who doesn't seem very concerned about it.

I have been diagnosed with MTHFR. Had my vit B tested and it is over 2000. That is the highest amount that labcocrp can test for. I am worried for the health of my liver. Can anyone tell me how to detox this from my liver?

@terriss were you tested for methylated B12?

@blowerk1216 My B12 was 1500 when last tested. I have MTHFR methyl B absorption issues.
Your body rids itself of extra B12 your body doesn't use when you pee. I have to give myself a B12 injection every week because if I don't, I have neuropathy in my arms, hands, legs and feet. The doctor told me that only 1% of his patients have this.

In other words, the B12 may be high, but due to the MTHFR, my body is not absorbing the B12 like it should.

I hope this helps.

Blessings & Prayers...

@covidstinks2023 can you not take methylated B12?

I have been taking B12 shots for about 2 years, have mthfr double 677 variant, celiac, neuropathy, hashimotos. Due to celiac I don't absorb B12 pills. You don't want synthetic B12 shot, it contains arsenic. Am still searching for help with mthfr.