1. < Heart & Blood Health
Profile picture for porscha

Is anyone on Repatha for cholesterol...

Posted by porscha @porscha, Dec 7, 2025

I'm taking Repatha shots every 2 weeks for cholesterol. So far, so good.
Has anyone experienced side effects...

Interested in more discussions like this? Go to the Heart & Blood Health Support Group.

Profile picture for manchild
manchild | @manchild | Mar 28 8:06am
In reply to @19281928 "@wgr123 I had awful joint pain with repatha could barely walk but I stuck it out..." + (show)
Profile picture for 19281928 @19281928

@wgr123 I had awful joint pain with repatha could barely walk but I stuck it out nearly a year and the pain was completely gone. I'm glad I stuck with it as it powered my lp@ and brought my LDL to 44.i can't take statins so this was my only hope

Jump to this post

@19281928
Please, all of you that use Repatha and have NO, or very minimal side effects, please chime in.

REPLY
1 reply
Profile picture for discernment
discernment | @discernment | Mar 31 6:52am
In reply to @margaretfriel "@writer418 Many years ago a Dr. shared: "We humans are like snowflakes, no 2 are alike."..." + (show)
Profile picture for margaretfriel @margaretfriel

@writer418
Many years ago a Dr. shared: "We humans are like snowflakes, no 2 are alike." How True ... a medication that works for 1 patient could be a big Problem to another!

Jump to this post

@margaretfriel
LDL in the 20's?? In my research, it sounds to me like that is too low. My cardiologist wasn't happy when mine was 130. She said get it to 100. When I got to 100 she said get it to 80 and now she's telling me get it to 50 or below! Just exactly how low is too low? LDL plays essential roles in the body, including the formation of cell membranes and the production of hormones.

REPLY
2 replies
Profile picture for Sue, Volunteer Mentor
Mentor
Sue, Volunteer Mentor | @sueinmn | Mar 31 8:41am
In reply to @manchild "@19281928 Please, all of you that use Repatha and have NO, or very minimal side effects,..." + (show)
Profile picture for manchild @manchild

@19281928
Please, all of you that use Repatha and have NO, or very minimal side effects, please chime in.

Jump to this post

@manchild I have been taking Repatha for over 2 years now. My only side effect is fatigue 12-24 hours after the injection, which I manage by taking the shot before bedtime and planning an easy "day after" - usually that means take Sunday night, go to bed early, and do paperwork, etc on Monday.
I had some other side effects I thought were from Repatha, they turned out to be from my arthritis meds, which we adjusted.
My LDL dropped from 110-120 to 70, without a statin (cannot tolerate). Next test due in a few weeks. We were already on a healthy diet with one "cheat day" a week.

REPLY
Profile picture for Janell, Volunteer Mentor
Mentor
Janell, Volunteer Mentor | @jlharsh | Mar 31 8:05pm
In reply to @discernment "@margaretfriel LDL in the 20's?? In my research, it sounds to me like that is too..." + (show)
Profile picture for discernment @discernment

@margaretfriel
LDL in the 20's?? In my research, it sounds to me like that is too low. My cardiologist wasn't happy when mine was 130. She said get it to 100. When I got to 100 she said get it to 80 and now she's telling me get it to 50 or below! Just exactly how low is too low? LDL plays essential roles in the body, including the formation of cell membranes and the production of hormones.

Jump to this post

@discernment Great news that you are able to control your LDL so well. Congrats!

I love what @margaretfriel says, just like snowflakes no two humans are alike. There lies the challenge with lipid management.

You bring up a great question about where LDL numbers should be. This brand new podcast is exactly what you may want to listen to. In addition to the role of Repatha and quite a few other topics surrounding cholesterol, it explains the science behind when and why 55 is the number to shoot for. Please come back and let me know what you think after you listen.

- Mayo Clinic Talks “Update In The Management of Hyperlidemia”
https://healthpodcastnetwork.com/episodes/mayo-clinic-talks/update-in-the-management-of-hyperlipidemia/
Have you had a conversation with your doctor about your unique risk factors and what her LDL goal is for you? You may have said this earlier, are you taking Repatha?

REPLY
Profile picture for phyllisq
phyllisq | @phyllisq | Apr 1 8:43am

I am on Repatha but am having a difficult time with the autoinjectors. I am about ready to give up and go back to statins. The side effects seem to be mild - less muscle and joint pain. A little nausea at first.

REPLY
3 replies
Profile picture for joyeous
joyeous | @joyeous | Apr 2 2:17pm
In reply to @phyllisq "I am on Repatha but am having a difficult time with the autoinjectors. I am about..." + (show)
Profile picture for phyllisq @phyllisq

I am on Repatha but am having a difficult time with the autoinjectors. I am about ready to give up and go back to statins. The side effects seem to be mild - less muscle and joint pain. A little nausea at first.

Jump to this post

@phyllisq
What kind of problem are you having with auto injector? I received mine but haven't started yet. I have read instructions and watched youtube video. I'm going to take first injection tonight. I wish it was just regular syringe with vial of med. Concerned I'm going to mess up.

REPLY
3 replies
Profile picture for toomanyquestions
toomanyquestions | @toomanyquestions | Apr 2 3:25pm

I had no trouble with injector, but my left foot and calf immediately went numb and had pins and needles and twitches. It lasted a couple of hours. The next day I was in bed all day exhausted. Today I am fine.

REPLY
Profile picture for 19281928
19281928 | @19281928 | Apr 2 5:09pm
In reply to @phyllisq "I am on Repatha but am having a difficult time with the autoinjectors. I am about..." + (show)
Profile picture for phyllisq @phyllisq

I am on Repatha but am having a difficult time with the autoinjectors. I am about ready to give up and go back to statins. The side effects seem to be mild - less muscle and joint pain. A little nausea at first.

Jump to this post

@phyllisq I'm happy with my repatha, no problem at all. Statins had awful side effects for me plus statins can increase my LP(@) I don't think I want that . What problems are you having please?

REPLY
Profile picture for 19281928
19281928 | @19281928 | Apr 2 5:10pm
In reply to @discernment "@margaretfriel LDL in the 20's?? In my research, it sounds to me like that is too..." + (show)
Profile picture for discernment @discernment

@margaretfriel
LDL in the 20's?? In my research, it sounds to me like that is too low. My cardiologist wasn't happy when mine was 130. She said get it to 100. When I got to 100 she said get it to 80 and now she's telling me get it to 50 or below! Just exactly how low is too low? LDL plays essential roles in the body, including the formation of cell membranes and the production of hormones.

Jump to this post

@discernment my cardiologist would be thrilled if mine was 20 (me too) mine is 60 and they want it below 50.

REPLY
Profile picture for 19281928
19281928 | @19281928 | Apr 2 5:11pm
In reply to @joyeous "@phyllisq What kind of problem are you having with auto injector? I received mine but haven't..." + (show)
Profile picture for joyeous @joyeous

@phyllisq
What kind of problem are you having with auto injector? I received mine but haven't started yet. I have read instructions and watched youtube video. I'm going to take first injection tonight. I wish it was just regular syringe with vial of med. Concerned I'm going to mess up.

Jump to this post

@joyeous don't worry, you will be fine , it's super easy 😊.it really helped lower my LDL within a few weeks

REPLY
Please sign in or register to post a reply.