Getting off of Seroquel

Posted by anniegk @anniegk, Jun 8, 2018

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks...I think that is too fast of a taper after being on a drug for over a year. What do you think?

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@osha9

This is my 1st post on mayoclinic; I'm just venting on the first topic I found on seroquel.

My psychiatrist had *refused to reduce my dosage from 200mg seroquel on our first outpatient followup appointment?

- At the time I thought it was causing cold intolerance, that would have me waking up in uncomfortable positions from tossing around if my shoulders weren't covered; otherwise with nightsweats. (I no longer think the seroquel caused nightsweats, have done general cancer screening twice that suggested I have leukocytesis, but this would require bone marrow biopsy to confirm leukemia.) That's besides the point

-> My psychiatrist explained that she wouldn't reduce my dosage because I sounded agitated; that the medication was for bipolar disorder.
*But I'm a total peace lover & have never been in a fight, wouldn't hurt a fly

So I played it cool, as a 27year old adult I brought my father to my next appointment.

I don't know why my father flipped sides on me during this next appointment, agreeing with my psychiatrist saying I just need to take the medication.

It seemed like there not even trying to reel-me-in at all. There is absolutely no evidence or history of bipolarism they can place upon me; except that I sounded agitated in this context of being told no.

I have never had trouble sleeping in the past. But ever since I quit seroquel I havent been able to sleep for more than 4 hours at a time.

That was almost a month ago, I really thought I'd bounce back by now.

I just don't understand why my father was so cruel as to side with my psychiatrist, telling me I can go to a different psychiatrist if I want different medication.

^While that is true, I will never trust a psychiatrist ever again. I do infact think I need the medication now, it was very effective.

It just seemed totally unreasonable, I'd almost have to rationalize that my psychiatrist has some prejudice against me. To outright refuse to reduce dosage of medication twice, with unsubstantiated claims - there is enough stigma for bipolar disorder that my psychiatrist should have been proud that I was comfortable reducing dosage.

I have met plenty of actual bipolar people, the kind of people that get really excited for sports &really upset when the ball is dropped.

It's just the way my psychiatrist looked me in the eyes; and my father nodded his head yes. I don't know what to do, melatonin doesn't even make me wink & over-the-counter medications don't seem like a long-term option.

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osha9
Why were you put on Seroquel in the first place? Are you bipolar or have symptoms of Bipolar?
I would never take a Neuroleptic drug for sleep. Seroquel is not recommend for insomnia. I have a friend who is schizophrenic and as a result of using Seroquel has developed Seroquel Induced Diabetes.
I believe that it's too soon to expect your sleep to return to normal. Your sleep may normalize in time using healthy sleep habits.
1.Go to bed & get up at the same time every day.
2. No caffeine 6-8 hrs before bed.
3. Sleep in cool, comfortable, dark room.
4. Don't use computers devices that emits blue or green light, computers, cell phones, TV’s, LED or fluorescent lights. digital clock.
5. Don't use alcohol or tobacco near bedtime.
6. Relax & lower or turn off lights after sundown.
7. Don't eat drink or exercise before going to sleep.
8. Exposure to sunlight in the morning and during the day is helpful.l
Some people here use a magnesium supplement to aid sleep but be cautious on becoming dependant on sleeping aids.
Good luck 💤,
Jake

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@osha9

This is my 1st post on mayoclinic; I'm just venting on the first topic I found on seroquel.

My psychiatrist had *refused to reduce my dosage from 200mg seroquel on our first outpatient followup appointment?

- At the time I thought it was causing cold intolerance, that would have me waking up in uncomfortable positions from tossing around if my shoulders weren't covered; otherwise with nightsweats. (I no longer think the seroquel caused nightsweats, have done general cancer screening twice that suggested I have leukocytesis, but this would require bone marrow biopsy to confirm leukemia.) That's besides the point

-> My psychiatrist explained that she wouldn't reduce my dosage because I sounded agitated; that the medication was for bipolar disorder.
*But I'm a total peace lover & have never been in a fight, wouldn't hurt a fly

So I played it cool, as a 27year old adult I brought my father to my next appointment.

I don't know why my father flipped sides on me during this next appointment, agreeing with my psychiatrist saying I just need to take the medication.

It seemed like there not even trying to reel-me-in at all. There is absolutely no evidence or history of bipolarism they can place upon me; except that I sounded agitated in this context of being told no.

I have never had trouble sleeping in the past. But ever since I quit seroquel I havent been able to sleep for more than 4 hours at a time.

That was almost a month ago, I really thought I'd bounce back by now.

I just don't understand why my father was so cruel as to side with my psychiatrist, telling me I can go to a different psychiatrist if I want different medication.

^While that is true, I will never trust a psychiatrist ever again. I do infact think I need the medication now, it was very effective.

It just seemed totally unreasonable, I'd almost have to rationalize that my psychiatrist has some prejudice against me. To outright refuse to reduce dosage of medication twice, with unsubstantiated claims - there is enough stigma for bipolar disorder that my psychiatrist should have been proud that I was comfortable reducing dosage.

I have met plenty of actual bipolar people, the kind of people that get really excited for sports &really upset when the ball is dropped.

It's just the way my psychiatrist looked me in the eyes; and my father nodded his head yes. I don't know what to do, melatonin doesn't even make me wink & over-the-counter medications don't seem like a long-term option.

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Try Chamomile supplements and Ltheanine supplements for sleep. All natural and can be quite effective.

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@mayo337xxx

U stopped cold turkey ?
How many mg daily ?
I was on 200 daily , titrated to 50 then bottom fell out
Went cold turkey : been awake 97% of the last 3 weeks ; took 50mg 3 days ago got about four hours sleep 2 days ago 50 mg no sleep
Last night nothing ; no sleep
This is worst than opiates and benzodiazepines which are both difficult
I guess the doctor forgot to mention consequences of cessation
I hate this drug ...
If I don’t take anymore when should I expect freedom

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I stand by my belief that Seroquel, Effexor and Paxil are worse than any benzo on the market.

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I was taking 400mg a day as prescribed by a psychiatrist that had me on so many meds that I was hallucinating and hearing things that didn’t exist. One result was that my car keys were taken away and my over the top, erratic behavior almost drove my wife away.

I honestly believe that the Seriquel was a major contributor to my problems so I started weaning myself off while at the same time looking for a new psychiatrist. I was blessed to find one that was also a pharmacologist. He told me that I was being grossly over medicated and started a 6 month duration of weaning me off of most of the meds that I was on. He about blew a gasket when I told him that before seeing him I weaned myself off of the Seriquel in 3 weeks.

Things are much better now but I still have a long road ahead of me.

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@gary1316

I was taking 400mg a day as prescribed by a psychiatrist that had me on so many meds that I was hallucinating and hearing things that didn’t exist. One result was that my car keys were taken away and my over the top, erratic behavior almost drove my wife away.

I honestly believe that the Seriquel was a major contributor to my problems so I started weaning myself off while at the same time looking for a new psychiatrist. I was blessed to find one that was also a pharmacologist. He told me that I was being grossly over medicated and started a 6 month duration of weaning me off of most of the meds that I was on. He about blew a gasket when I told him that before seeing him I weaned myself off of the Seriquel in 3 weeks.

Things are much better now but I still have a long road ahead of me.

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@gary1316
3 weeks seems fast. Did you have any withdrawal symptoms?
Congratulations and take care,
Jake

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@jakedduck1

@gary1316
3 weeks seems fast. Did you have any withdrawal symptoms?
Congratulations and take care,
Jake

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I became jittery and started to become a little manic.

My wife and I have a 16 acre homestead that is in a very remote area about 3hrs from the valley.... she took me up there with the expectations of waiting out the withdrawals. I am truly blessed to have her for my wife. We were prepared for the worse but it never arrived. Everything worked out well and after 4 days we returned to the valley.

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I take 800 mg of seroquel at night. I've been taking that dose for about 4 years. I have tried reducing the dose several times, and it is always a disaster for me. I keep trying because I struggle with the weight gain, and I think it also makes me tired during the day and might dull my emotions. Also it is the highest dose and I just would like to take less. I have bipolar 1 disorder diagnosed maybe 20 years ago. Like a lot of people with mental health challenges, I been on so many medications, often prescribed by different doctors at different points in my mood cycles. The medications that have always worked the best for me are seroquel and prozac. I take lamotrigine and welbutrin also, but what I know for sure is that the seroquel and prozac keep me pretty steady, seroquel hleps so much with anxiety and agitation and keeps manic spirals away. I don't know why, but prozac has always helped with depression. I was taking 80 mg of prozac, but it was reduced to 40mg when I started taking seroquel and that has been fine. I'm rambling here but all of this to say that I tried to reduce the seroquel again a couple days ago, and I'm about to lose it. I'm going to go back to the normal dose tonight. I think I just wrote this post to confirm my decision to my self. 🙂 Everybody is different, but for me reducing seroquel (I've tried at least 3-4 times) is awful. I feel like it is so helpful for me that the side affects are less important, and I've concluded (again) that I need that 800 mg. Ugh.

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This is a long overdue follow-up, I was here more than a year ago. Coming off seroquel was by far the worst experience of my life, had to stay with my parents. All I remember is dry-heaving and not sleeping for days on end. There was one point when I couldn't tell the difference between reality and whatever the opposite is. I'm trying to forget about it but figured I'd pass along some words of encouragement so maybe somebody won't give up.

It took about 2-3 months before things resolved. It wasn't like flipping a light switch either, recovery was very gradual. It's going to be an absolute nightmare but it's worth it in the end. In the meantime, force yourself to get up and do something like walk around the park. Anything to keep distracted. When you feel a little better, exercise a bit. Don't worry about not being able to eat and losing weight, it'll return. I lost about 20-30lbs through the ordeal but gained it all back once my appetite returned. For nausea: Eat Yogurt! Lots of it. It helped me and other members on reddit have confirmed that it works for them, too. Those yogurt drinks are really good, I highly recommend them. Don't bother with taking your xanax or ativan to tone down the withdrawals and get some sleep, it will not help. I dont recommend falling back and taking your seroquel, it helped very briefly but the withdrawals came back within a matter of days. Just throw your pills out and don't look back.

Then it was a matter of finding the right medication, this took a long time. First I increased my paxil, that didnt work. Switched to lexapro, too many side effects. Added wellbutrin, it was fun but short-lived. Finally settled on zoloft. Turns out zoloft is the most prescribed ssri and something like the 15th most prescribed medication in the united states. I'm still taking 1.25mg of klonopin per day, I've tapered off of it in the past but want to stay on it. My advice is do not take Seroquel unless you have a specific diagnosis of schizophrenia and have exhausted other drugs. Astra-zeneca was sued for a gazillion dollars for off-label marketing. If your doctor gives you something like agitation, mood disorder, sleep disorder..Don't fall for it, there are better, safer drugs.

And now if you'll excuse me, I'm going to forget about it once more. This was a dark chapter, so hopefully for the rest of my life. Good luck.

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Hello, I’ve been taking 100mg of Seroquil at bed time for about a year after being prescribed it in a treatment center. I’ve been taking it every night but I feel very lethargic during the day and in the morning because of it. I want to get off of it very badly so I cut my dosage to 50mg for the past two weeks but I don’t feel any difference yet in the morning. Can someone please let me know how I can get off it completely? I would stop taking it every night but I can’t sleep now when I don’t take it since the doctors put me on it, I wish they never did! Thank you 🙏

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@stlr21

Hello, I’ve been taking 100mg of Seroquil at bed time for about a year after being prescribed it in a treatment center. I’ve been taking it every night but I feel very lethargic during the day and in the morning because of it. I want to get off of it very badly so I cut my dosage to 50mg for the past two weeks but I don’t feel any difference yet in the morning. Can someone please let me know how I can get off it completely? I would stop taking it every night but I can’t sleep now when I don’t take it since the doctors put me on it, I wish they never did! Thank you 🙏

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Hi @stlr21, lots and lots of members talking about Seroquel in this discussion like @osha9, @gary1316, @amy8297 and @chrisjc. Hopefully you can find answers to help you get off the medication, however, just like your previous post, I would never recommend doing so without the help of a physician. I think Chris and Gary can attest to the intensity of the withdrawals.

Were you prescribed this at the same time as the other medication that you are taking?

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