Getting off of Seroquel

Posted by anniegk @anniegk, Jun 8, 2018

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks…I think that is too fast of a taper after being on a drug for over a year. What do you think?

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@sabi

I have been on Seroquel for about 5years for insomnia. I've gained an excessive amount of weight and am now displaying symptoms of insulin resistance. My doctor has taken me off of Seroquel but it was kind of abruptly and now I'm suffering from withdrawal. Brain zaps, horrible náusea, vomiting, diarrhea, headaches and insomnia. Has anyone else gone through this, and if so, how did you deal?

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Welcome @sabi. I'm sorry to hear that your taper was too fast and that you're suffering with the symptoms of withdrawal syndrome. You'll notice that I moved your message to this existing discussion that @anniegk started on the same topic.
– Getting off of Seroquel https://connect.mayoclinic.org/discussion/seroquel-withdrawal/

I did this so you can read past posts and connect more easily with members who can offer tips and share their experineces like @anniegk @jh1 @jimhd @chrisjc and others.

This related discussion may also offer some helpful advice:
– How can I support my girlfriend who has to come off Seroquel? https://connect.mayoclinic.org/discussion/seroquel-withdrawal/

Have you talked to your doctor about tapering more slowly or a bridge medication?

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Seroquel. I’ve had four root canals within one year. I have been on 400 mg Seroquel for 2 years. I think Seroquel could cause tooth decay because it causes dry mouth, elevated blood sugar, bruxism and maybe something else. I believe it can also cause alveolar bone loss which is causing more space at the base of my teeth. Has anybody had tooth decay from Seroquel? There is some information about Seroquel and tooth decay online.

Now I want to get off the Seroquel. I’m on 50 mg ER and 350 mg regular at bedtime. If I reduce the dosage it’s hard to sleep. I think even cutting by 12.5 mg per month will be difficult. Does anybody have experience or recommendations on how to get off Seroquel? Perhaps I could use Ambien, Ativan, benzodiazepines, Remeron and or liquid magnesium while I am quitting Seroquel. Any recommendations?

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@insomniac

Seroquel. I’ve had four root canals within one year. I have been on 400 mg Seroquel for 2 years. I think Seroquel could cause tooth decay because it causes dry mouth, elevated blood sugar, bruxism and maybe something else. I believe it can also cause alveolar bone loss which is causing more space at the base of my teeth. Has anybody had tooth decay from Seroquel? There is some information about Seroquel and tooth decay online.

Now I want to get off the Seroquel. I’m on 50 mg ER and 350 mg regular at bedtime. If I reduce the dosage it’s hard to sleep. I think even cutting by 12.5 mg per month will be difficult. Does anybody have experience or recommendations on how to get off Seroquel? Perhaps I could use Ambien, Ativan, benzodiazepines, Remeron and or liquid magnesium while I am quitting Seroquel. Any recommendations?

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Is there any relationship between Seroquel and tooth decay?

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@tiffanyvillier

Has anyone successfully “gotten off” seroquel?

I’ve been taking it for 5 years (100mgXR). I tried my own slow taper, cutting down by 25mg every 3 weeks. Once off, I ended up in psychiatric care for 2 weeks, and put right back on it. I also got a new diagnosis of “Schizophrenic” as a result of the stay.

I’m going to see my Psychiatrist in November and I’m going to ask about a supervised-taper of sorts.

The effects I don’t want to deal with anymore:
-Dead libido
-Yawning/Tremors from waking until around 6 hours later
-General feeling of malaise

Is it possible to be completely free of mood stabilizers? Or, are there any proven medications that don’t come with typical side-effects?

Some background:
My first manic episode was at 31 years of age. I was diagnosed as manic bipolar after being mostly awake for 6 days straight. (I would nod off and not realize I had gone to sleep.) I also quit drinking heavily, cold-turkey, 2 weeks prior.

Thanks for any input!

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I’m currently tapering off seroquel and experiencing rebound mania, but I feel like a new woman! I wanted to reply to this post because, YES, it absolutely can be possible to be free from mood stabilizers. In 2015 I went through a 5 day medically supervised alcohol withdrawal program. Tried AA for a while but what really changed my life was a local WRAP class. Mary Ellen Copeland was taking lithium in the 80s for her bipolar, developed toxicity to it and had to figure out to manage her life without medication. She ended up developing the Wellness Recovery Action Plan program. I took the class 5 times then trained to be a facilitator for it. Anyway more recently I have found that Keto diet really helped stabilize my moods. Best wishes!

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I have bipolar and was using a low-dose of Seroquel (100-150mg) in addition to my regular meds (at the time, Latuda and Trileptal) for sleep. I realized after a period of time that it was no longer helping and made the decision to stop taking it. My doctor said that was fine. I did experience some rebound insomnia. The first night I was off it, I slept 3 hours. And felt more restored in those 3 hours than in 8 hours with it. I also gained 35 pounds. And I was doing a lot of caffeine to overcome the grogginess.

I now take melatonin and some hydroxyzine (can't do OTC benedryl). Like you, I feel like a new woman. I also take Omegas which can help stabilize mood. I did my thesis in my MS (nutrition) program on mental health diet. So much can be done there. For bipolar, a probiotic will help, as will the B-vitamins. But of course working with your doctor. I'm interested in the WRAP program.

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@catmomma

I have bipolar and was using a low-dose of Seroquel (100-150mg) in addition to my regular meds (at the time, Latuda and Trileptal) for sleep. I realized after a period of time that it was no longer helping and made the decision to stop taking it. My doctor said that was fine. I did experience some rebound insomnia. The first night I was off it, I slept 3 hours. And felt more restored in those 3 hours than in 8 hours with it. I also gained 35 pounds. And I was doing a lot of caffeine to overcome the grogginess.

I now take melatonin and some hydroxyzine (can't do OTC benedryl). Like you, I feel like a new woman. I also take Omegas which can help stabilize mood. I did my thesis in my MS (nutrition) program on mental health diet. So much can be done there. For bipolar, a probiotic will help, as will the B-vitamins. But of course working with your doctor. I'm interested in the WRAP program.

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Please forgive me for zeroing in on one aspect only of your post – the Seroquel. You said you took 100-150 Seroquel for sleep. That's just how much I take and why.

When you said you gained 35 lbs did you mean before or after quitting it?

Thank you.

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