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anniegk
@anniegk

Posts: 120
Joined: Jul 25, 2017

Getting off of Seroquel

Posted by @anniegk, Fri, Jun 8 12:40pm

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks…I think that is too fast of a taper after being on a drug for over a year. What do you think?

REPLY

Hi, @anniegk — I apologize for not responding earlier, but somehow I missed getting a notification about your post! I'm wondering about how your taper off of Quetiapine (Seroquel) has been going.

I'd like to invite @derryman @IndianaScott @loveallmyboys @whereveryougothereyouare @tib85 @giacamosgirl58 @majic @hwilson7 @resolve @ronlin1948 @ginak523 and @cathy615 into this discussion to share their thoughts and experiences with Quetiapine (Seroquel)and tapering, if that applies. @gailb and @gman007 may also have some thoughts about the journey going off this medication and the side effects you've experienced.

You mentioned taking Quetiapine (Seroquel) in addition to Remeron (Mirtazapine) and then deciding to try and get off the Seroquel. Curious about what made you want to discontinue the medication? Were you having unpleasant side effects?

@lisalucier

Hi, @anniegk — I apologize for not responding earlier, but somehow I missed getting a notification about your post! I'm wondering about how your taper off of Quetiapine (Seroquel) has been going.

I'd like to invite @derryman @IndianaScott @loveallmyboys @whereveryougothereyouare @tib85 @giacamosgirl58 @majic @hwilson7 @resolve @ronlin1948 @ginak523 and @cathy615 into this discussion to share their thoughts and experiences with Quetiapine (Seroquel)and tapering, if that applies. @gailb and @gman007 may also have some thoughts about the journey going off this medication and the side effects you've experienced.

You mentioned taking Quetiapine (Seroquel) in addition to Remeron (Mirtazapine) and then deciding to try and get off the Seroquel. Curious about what made you want to discontinue the medication? Were you having unpleasant side effects?

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I just stopped it cold turkey and feel much better ! Thank you for responding .

Seroquel was a great drug for reg depression, however I’ve tapered down from 150mg to 25 mg now, maybe in about a month I will be off. I tried old turkey, but I got brain zaps and hypnic jerks at night. My doc has me on trazadone now. I haven’t noticed any change in my heart issue though. I was hoping that it would get better. Idiopathic heart failure is my diagnosis. Apparently it may have been caused by a virus or some other factors. It is fairly common in the cardiomyopathy community

@tib85

Seroquel was a great drug for reg depression, however I’ve tapered down from 150mg to 25 mg now, maybe in about a month I will be off. I tried old turkey, but I got brain zaps and hypnic jerks at night. My doc has me on trazadone now. I haven’t noticed any change in my heart issue though. I was hoping that it would get better. Idiopathic heart failure is my diagnosis. Apparently it may have been caused by a virus or some other factors. It is fairly common in the cardiomyopathy community

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Did your doctor ever think that Seroquel caused problems with your heart @tib85?

I am also tapering off of Seroquel I was on 200mg xr and 200mg at bedtime. I started tapering down the Seroquel at bedtime at 50 mg increments every two weeks. Then I started tapering the Seroquel xr at from 200mg to 150 mg every two months . I am now on 50 mg of Seroquel xr. I also take .5 mg of clonazepam twice a day. I have had some episodes of insomnia so I am now taking 3mg of melatonin at night to help me sleep. The problem is that there isn't a lower dosage after the 50mg of Seroquel xr. Which makes it difficult to taper without any negative side effects. ( for example rebound insomnia). So I guess we are both having the same problem.

I think that you should take your time to taper off of Seroquel xr. My psychiatrist suggested a slow taper for this drug. Three weeks is too shore to come off of this medication.

Has anyone successfully “gotten off” seroquel?

I’ve been taking it for 5 years (100mgXR). I tried my own slow taper, cutting down by 25mg every 3 weeks. Once off, I ended up in psychiatric care for 2 weeks, and put right back on it. I also got a new diagnosis of “Schizophrenic” as a result of the stay.

I’m going to see my Psychiatrist in November and I’m going to ask about a supervised-taper of sorts.

The effects I don’t want to deal with anymore:
-Dead libido
-Yawning/Tremors from waking until around 6 hours later
-General feeling of malaise

Is it possible to be completely free of mood stabilizers? Or, are there any proven medications that don’t come with typical side-effects?

Some background:
My first manic episode was at 31 years of age. I was diagnosed as manic bipolar after being mostly awake for 6 days straight. (I would nod off and not realize I had gone to sleep.) I also quit drinking heavily, cold-turkey, 2 weeks prior.

Thanks for any input!

@tiffanyvillier

Has anyone successfully “gotten off” seroquel?

I’ve been taking it for 5 years (100mgXR). I tried my own slow taper, cutting down by 25mg every 3 weeks. Once off, I ended up in psychiatric care for 2 weeks, and put right back on it. I also got a new diagnosis of “Schizophrenic” as a result of the stay.

I’m going to see my Psychiatrist in November and I’m going to ask about a supervised-taper of sorts.

The effects I don’t want to deal with anymore:
-Dead libido
-Yawning/Tremors from waking until around 6 hours later
-General feeling of malaise

Is it possible to be completely free of mood stabilizers? Or, are there any proven medications that don’t come with typical side-effects?

Some background:
My first manic episode was at 31 years of age. I was diagnosed as manic bipolar after being mostly awake for 6 days straight. (I would nod off and not realize I had gone to sleep.) I also quit drinking heavily, cold-turkey, 2 weeks prior.

Thanks for any input!

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Hello, @tiffanyvillier – welcome to Mayo Clinic Connect.

As you mentioned a diagnosis of manic bipolar and also schizophrenia, I'd also like to introduce you to @liz223 @amberpep @gailb @gummal @parus @hoffman who have either mentioned schizophrenia or bipolar and may have some thoughts for you about successfully getting off quetiapine (Seroquel), your experience tapering where you ended up in psychiatric care, the side effects you don't want to deal with anymore, and your proposed supervised taper.

@tiffanyvillier – have you tried other medications previously for your diagnoses? If so, what were they, and how did they work for you?

@linda66

I am also tapering off of Seroquel I was on 200mg xr and 200mg at bedtime. I started tapering down the Seroquel at bedtime at 50 mg increments every two weeks. Then I started tapering the Seroquel xr at from 200mg to 150 mg every two months . I am now on 50 mg of Seroquel xr. I also take .5 mg of clonazepam twice a day. I have had some episodes of insomnia so I am now taking 3mg of melatonin at night to help me sleep. The problem is that there isn't a lower dosage after the 50mg of Seroquel xr. Which makes it difficult to taper without any negative side effects. ( for example rebound insomnia). So I guess we are both having the same problem.

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Try asking your pharmacist to make a liquid solution of Seroquel. Then you titrate down in very small decrements.

I have gotten off 600mg Seroquel but not the XR. It was being used to help me sleep probably anti anxiety as well. It was tough and took about 6 months but I have been off it about 6 months now. Tons of nausea when I went off it but my doctor explained it absolutely is normal because it does work on some sort of anti nausea brain receptors. I got down to 25mg then stopped. I’m still completing a benzodiazepine taper but I am glad I got off the Seroquel as it fogged my thinking.

@maclodge

Hi I was put on 800 mg of quetiapine 7 years ago. Over the years I slowly got it down to 150mg. I thought things were going great so I lowered it to 100 then 50mg . I had no side affects…..then bam it's like I've hit a brick wall, feel horrendous, dizzy, depressed, very anxious and agitated 😥. I feel I need to put them back up sadly. But so want off this meds! Anyone else having a nightmare reducing ? Tia

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I've been on 100 mg for 4 years. Although it has worked well as a mood-stabilizer and kept me off drugs and alcohol, I hated the morning brain fog. I tried to taper off too quickly and had horrible side effects – deep depression, head-aches, total loss of energy and of course insomnia. I am now back up to 50 mg after going from 100 to 50 to 25 to zero in a week. I feel I have to go much slower this time. I'll prob do 50 / 25 every other night for a month, then 25 every night for a month, then 25 / zero every night for another month so we are talking very very slow. It was no problem going from 100 to 50 at all. That's why I guess I kept going so rapidly. There's something that happens when you get to those lower doses like it's almost more intense of an effect. I hope that helps! A

Hi I was put on 800 mg of quetiapine 7 years ago. Over the years I slowly got it down to 150mg. I thought things were going great so I lowered it to 100 then 50mg . I had no side affects…..then bam it's like I've hit a brick wall, feel horrendous, dizzy, depressed, very anxious and agitated 😥. I feel I need to put them back up sadly. But so want off this meds! Anyone else having a nightmare reducing ? Tia

Hello everyone.
@lisalucier
I have been on 25mg quentiapine for about a month or so. I took around 40 pills in that time. I realized it's just pure shi*t so I stopped taking it. It was hard the first week, but than all withdrawall symptoms went away. My question is can I have some long term side effects because taking it for 1 month.

@freddymercury

Hello everyone.
@lisalucier
I have been on 25mg quentiapine for about a month or so. I took around 40 pills in that time. I realized it's just pure shi*t so I stopped taking it. It was hard the first week, but than all withdrawall symptoms went away. My question is can I have some long term side effects because taking it for 1 month.

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@freddymercury The only adverse effects I am aware of were deep cataracts in less than a year. I cannot prove this is what caused them, but my eye doctor of many years had seen it before in patients with eyes that were healthy. Scary.

I was on Seroquel for 3 years and then went on to Olanzapine. I titrated for many months, but the withdrawal symptoms seemed to be endless. I have been off of them both for 3 months now and I am still wondering if some of my symptoms are related to the withdrawal. I researched theses drugs and not only are they dangerous, they can impact your chemistry for life. Very bad drugs.

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