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Is anyone on Repatha for cholesterol...

Posted by porscha @porscha, Dec 7, 2025

I'm taking Repatha shots every 2 weeks for cholesterol. So far, so good.
Has anyone experienced side effects...

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rmasters | @rmasters | 2 days ago
In reply to @rosie96 "I wrote previously that I experienced severe insomnia soon after beginning Repatha, although reported such side..." + (show)
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I wrote previously that I experienced severe insomnia soon after beginning Repatha, although reported such side effects are rare. I know it was due to the Repathad becaue I had no problem prior to taking it.
I stopped taking it two months ago but insomnia did not abate. I am now taking Trazedone to sleep.
On 40 mg atorvastatin and 10 mg of Zetia but too early to tell if that is working to reduce cholesterol.
Repatha is very effective but apparently has many side effects.

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@rosie96
Ijust started repatha and have noticed a lot of trouble sleeping. i'm also already on trazadone. How many doses did you have before stopping. I think i will ask to stop now and go back to my muscle aches on crestor

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rmasters | @rmasters | 2 days ago
In reply to @mbbeatley "I've had two doses of Repatha and my side effects are mild but difficulty sleeping now..." + (show)
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I've had two doses of Repatha and my side effects are mild but difficulty sleeping now and muscle pain in my legs at night. I've started taking pain medication at bedtime for the muscle pain, but not sure what to do about the difficulty sleeping. I've never had this problem and I love my sleep! Any suggestions?

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@mbbeatley i just had one dose of repatha 3 days ago no side effects except cant fall asleep which is a big one. I think i iwill ask my dr to hold off on next dose and go back to crestor.Crestor gave me muscle aches but not sleeping. Hoping this adjusts soon

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rmasters | @rmasters | 2 days ago

Can someone please respond to the insomnia related to beginning Repatha. I just had one dose 3 days ago and haven't been able to fall asleep and I already take trazadone for sleep. I am not going to have another dose. I will ask my cardiologist to put me back on crestor. It won't keep my cholesterol below 65 but sleeping is a priority. Did anyone experience this after just one dose and did you go on to a second dose?

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abosier65 | @abosier65 | 1 day ago
In reply to @rmasters "@rosie96 Ijust started repatha and have noticed a lot of trouble sleeping. i'm also already on..." + (show)
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@rosie96
Ijust started repatha and have noticed a lot of trouble sleeping. i'm also already on trazadone. How many doses did you have before stopping. I think i will ask to stop now and go back to my muscle aches on crestor

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@rmasters I'm allergic to stations and so I do the Repatha injections once every 2 weeks. I'm also on 300mg of Trazadone at night. It took just 2 months and I'm back to sleeping ok.

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rmasters | @rmasters | 1 day ago
In reply to @abosier65 "@rmasters I'm allergic to stations and so I do the Repatha injections once every 2 weeks...." + (show)
Profile picture for abosier65 @abosier65

@rmasters I'm allergic to stations and so I do the Repatha injections once every 2 weeks. I'm also on 300mg of Trazadone at night. It took just 2 months and I'm back to sleeping ok.

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@abosier65
thank you for the response Did you experience any fatigue or muscle aches with the repatha?

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abosier65 | @abosier65 | 15 hours ago
In reply to @rmasters "@abosier65 thank you for the response Did you experience any fatigue or muscle aches with the..." + (show)
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@abosier65
thank you for the response Did you experience any fatigue or muscle aches with the repatha?

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@rmasters I already have fatigue and muscle issues before so I noticed just a little difference and then it went back to my normal messieness

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swilkins1974 | @swilkins1974 | 13 hours ago
In reply to @rmasters "@mbbeatley i just had one dose of repatha 3 days ago no side effects except cant..." + (show)
Profile picture for rmasters @rmasters

@mbbeatley i just had one dose of repatha 3 days ago no side effects except cant fall asleep which is a big one. I think i iwill ask my dr to hold off on next dose and go back to crestor.Crestor gave me muscle aches but not sleeping. Hoping this adjusts soon

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@rmasters my first dose was like that. My 2nd was fine. My 3rd exact opposite extremely tired. Also it has produced a feeling of foreboding. This is concerning as I do not suffer from depression. I also have this sensation of leg weakness but they are not weak. My 4th shot is this week which I am dreading.

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hsminc | @hsminc | 7 hours ago

My husband is on Repatha, He has had no problems with it. The injection every other week has reduced his lp(a) by one third. His cholesterol is down to 113 and the LDL to about 35.
A new form of this type of medication was just approved by the FDA. It is taken every day in pill form. I don't know how much it costs or insurer's response to it.

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