diastolic dysfunction effects and treatmetn

Posted by ohallk @ohallk, Jun 27 3:29pm

I sometimes feel like I can hardly move after a 45 minute walk, even though I've been a runner/walker all my life. Also - many mornings, it is so much work to expand my diaphragm just to get a good breath. This lasts for 1 - 3 hours. Sometimes I will use an Albuterol inhaler though I blow my usual normal 325-350 on my peak flow meter (occasional, mild asthma). I am being treated w/Jardiance (10 mg) for heart and also do a Repatha injection once every 14 days. Mu sister, former dialysis nurse, says it's my heart that is causing the exhaustion after exercise - that I'm simply not getting enough blood flowing and that's causing the exhaustion. The exhaustion is not sleepiness - it's an "I can't move exhaustion."
Is my sister's dx spot on? Is the left ventricle simply not sending enough blood over to the right chamber and thus to all my muscles? Same w/ many mornings? I'm quite certain it's not asthma. Looking for info from others. Do you experience this? Is using an inhaler bad when it's not asthma? (I know - I should ask my doc about this - and I will when I see her in a couple weeks but wanted to know what others experience 1st. -

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She may be on to something, but there are a several possibilities. You may need to consult a pulmonologist to check out your lungs. A heart specialist will soon find out if you have valvular defects, or ventricular enlargement, a poor ejection fraction, or even an arrhythmia such as atrial fibrillation. You may even be anemic!!

You should consult a physician soonest.

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Are you on the Jardiance for diastolic dysfunction? I would definitely consult a cardiologist.

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Profile picture for gloaming @gloaming

She may be on to something, but there are a several possibilities. You may need to consult a pulmonologist to check out your lungs. A heart specialist will soon find out if you have valvular defects, or ventricular enlargement, a poor ejection fraction, or even an arrhythmia such as atrial fibrillation. You may even be anemic!!

You should consult a physician soonest.

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@gloaming
thanks for your response. I contacted my cardiologist and i now have a pulmonary function test set up. We'll see how that turns out and go from there. It never occurred to me that I might be anemic. Good advice from you re: paths to pursue.
thanks

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Profile picture for altilla @altilla

Are you on the Jardiance for diastolic dysfunction? I would definitely consult a cardiologist.

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@altilla
Yes - I don't have diabetes. It was prescribed for the diastolic dysfunction. I will be seeing my cardiologist in Oct. but was thinking I might need to move that appt up.

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Profile picture for ohallk @ohallk

@altilla
Yes - I don't have diabetes. It was prescribed for the diastolic dysfunction. I will be seeing my cardiologist in Oct. but was thinking I might need to move that appt up.

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@ohallk When I was put on Jardiance for HFpEF/diastolic dysfunction it helped a lot for a couple months. Then not so much. Fingers crossed for you and that find definitive answers.

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Profile picture for ohallk @ohallk

@altilla
Yes - I don't have diabetes. It was prescribed for the diastolic dysfunction. I will be seeing my cardiologist in Oct. but was thinking I might need to move that appt up.

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I've never heard of Jardiance for dystolic dysfunction. I have grade 2 dystolic dysfunction

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Profile picture for asolidrock @asolidrock

I've never heard of Jardiance for dystolic dysfunction. I have grade 2 dystolic dysfunction

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Hi @asolidrock
Yes, Jardiance has been shown to help patients with heart failure.
Here is what I found online that you may find interesting:
Jardiance (empagliflozin) is an SGLT2 inhibitor FDA-approved to reduce the risk of cardiovascular death and hospitalization for heart failure in adults, regardless of diabetes status or left ventricular ejection fraction (LVEF). It is the first therapy to demonstrate significant benefit for both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), addressing a previously significant unmet medical need.

The medication works by promoting the excretion of excess sodium and glucose through urine, which reduces fluid retention and lowers the workload on the heart. Clinical trials (EMPEROR-Reduced and EMPEROR-Preserved) showed that Jardiance significantly decreases the combined risk of cardiovascular death and heart failure hospitalization, with benefits observed in patients with or without type 2 diabetes.

Common side effects include increased urination, genital yeast infections, and urinary tract infections (UTIs). Jardiance is typically taken as a 10 mg tablet once daily and may cause modest weight loss or lower blood pressure. Serious but rare risks include ketoacidosis (even in non-diabetics) and dehydration, particularly if used with other diuretics.

This is the beauty of Mayo Clinic Connect...we can learn so much from each other!
Have you thought to ask your cardiologist if this would be something that may help you?

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Wow that is interesting; thank you for sharing. I haven't been diagnosed with chf but I have 2 brotherinlaws that take medication for it.; I am gonna ask my cardiologist about and share with my inlaws.

Thanks again

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Profile picture for Debra, Volunteer Mentor @karukgirl

Hi @asolidrock
Yes, Jardiance has been shown to help patients with heart failure.
Here is what I found online that you may find interesting:
Jardiance (empagliflozin) is an SGLT2 inhibitor FDA-approved to reduce the risk of cardiovascular death and hospitalization for heart failure in adults, regardless of diabetes status or left ventricular ejection fraction (LVEF). It is the first therapy to demonstrate significant benefit for both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), addressing a previously significant unmet medical need.

The medication works by promoting the excretion of excess sodium and glucose through urine, which reduces fluid retention and lowers the workload on the heart. Clinical trials (EMPEROR-Reduced and EMPEROR-Preserved) showed that Jardiance significantly decreases the combined risk of cardiovascular death and heart failure hospitalization, with benefits observed in patients with or without type 2 diabetes.

Common side effects include increased urination, genital yeast infections, and urinary tract infections (UTIs). Jardiance is typically taken as a 10 mg tablet once daily and may cause modest weight loss or lower blood pressure. Serious but rare risks include ketoacidosis (even in non-diabetics) and dehydration, particularly if used with other diuretics.

This is the beauty of Mayo Clinic Connect...we can learn so much from each other!
Have you thought to ask your cardiologist if this would be something that may help you?

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@karukgirl
Thanks for your feedback. I I believe my LVEF is mild at this point and am on Jardiance - or HFrEF is probably the proper terminology and I understand the way Jardiance works. I am having lung function testing in a week. I'll be eager to see what that shows. My frustration is that I can still work hard and/or go for a brisk walk but am totally drained afterwards. (I know - I'll be 78 in 2 weeks), but I was a runner, x-c skier, biker....and am frustrated w/my body shutting down to the point where I feel like I can hardly move after exercise.
I do appreciate Mayo Clinic Connect for the opportunity to learn from others and if my lung function tests show nothing significant, I will contact my cardiologist again and ask where to go next....

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Profile picture for ohallk @ohallk

@karukgirl
Thanks for your feedback. I I believe my LVEF is mild at this point and am on Jardiance - or HFrEF is probably the proper terminology and I understand the way Jardiance works. I am having lung function testing in a week. I'll be eager to see what that shows. My frustration is that I can still work hard and/or go for a brisk walk but am totally drained afterwards. (I know - I'll be 78 in 2 weeks), but I was a runner, x-c skier, biker....and am frustrated w/my body shutting down to the point where I feel like I can hardly move after exercise.
I do appreciate Mayo Clinic Connect for the opportunity to learn from others and if my lung function tests show nothing significant, I will contact my cardiologist again and ask where to go next....

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@ohallk, I love your attitude!!
I am frustrated with me too!
Why can't I be like I was when I was 30? Or 40. Or even my 50's?
In my head I can still do cartwheels! But reality?...if I tried, somebody would end up calling 9-11! So even if I think I still can...I'm learning I can...but slower and not as much. Or maybe let's try something less teenager and more senior citizen. Not easy to accept. Except the cartwheels. That's a no go.
PS: 78 is young in my opinion!

Your wonderful feedback is part of the reason Mayo Clinic Connect works so well.
We can share with one another our stories and learn from each other.
We can share our frustrations with each other and sympathize with each other.
We were all there once, and could do this, or could do that...and yet not anymore and we are not what we used to be!
Sigh...
So, though we are are not giving medical advice, no, we can't do that, but we can still shed light on places others may not know about. That furthers learning about what we may or may not have, and may or may not know. You never know what you share here on Connect may impact someone in a huge way.

Don't give up! You can persist and keep searching for more information from your doctor. And if you don't feel it connects with you, you can seek a second, third or how ever many opinions you need to come to the place you are certain you know.
My heart was failing, but it was due to hypertrophic cardiomyopathy. I was able to turn that around after open heart surgery. It's not the same. But I think I can understand what it feels like on some level.
When do you see your cardiologist again? Are you on Jardiance? Or thinking of it?

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