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Discussiondiastolic dysfunction effects and treatmetn
Heart & Blood Health | Last Active: 5 hours ago | Replies (19)Comment receiving replies
Replies to "I've never heard of Jardiance for dystolic dysfunction. I have grade 2 dystolic dysfunction"
@asolidrock
I have grade 2 diastolic dysfunction which caused HFpEF and pulmonary hypertension. I was prescribed Jardience but it has only been about 10 days so too soon to expect change. The DD causes cardiac remodeling of the ventricle ( can be left or right) which means the ventricle becomes thicker and stiff making it hard for the ventricle to fill with blood and pump to the rest of the body. This can cause shortness of breath and fatigue and the feeling like your muscles aren't getting enough blood or oxygen.
Connect

Hi @asolidrock
Yes, Jardiance has been shown to help patients with heart failure.
Here is what I found online that you may find interesting:
Jardiance (empagliflozin) is an SGLT2 inhibitor FDA-approved to reduce the risk of cardiovascular death and hospitalization for heart failure in adults, regardless of diabetes status or left ventricular ejection fraction (LVEF). It is the first therapy to demonstrate significant benefit for both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), addressing a previously significant unmet medical need.
The medication works by promoting the excretion of excess sodium and glucose through urine, which reduces fluid retention and lowers the workload on the heart. Clinical trials (EMPEROR-Reduced and EMPEROR-Preserved) showed that Jardiance significantly decreases the combined risk of cardiovascular death and heart failure hospitalization, with benefits observed in patients with or without type 2 diabetes.
Common side effects include increased urination, genital yeast infections, and urinary tract infections (UTIs). Jardiance is typically taken as a 10 mg tablet once daily and may cause modest weight loss or lower blood pressure. Serious but rare risks include ketoacidosis (even in non-diabetics) and dehydration, particularly if used with other diuretics.
This is the beauty of Mayo Clinic Connect...we can learn so much from each other!
Have you thought to ask your cardiologist if this would be something that may help you?