Wegovy, then switched to a compounded formula of semaglutide

Posted by bhb30602 @bhb30602, Jun 9, 2025

A month ago, my PCP gave me a free sample of .25 Wegovy (month's supply) and I take the 4th jab tomorrow. Since my insurance won't cover Wegovy, he prescribed a compound formula of semaglutide with pyridoxine and glycine and increased the dose to .50mg. The pyridoxine (B6) for possible nausea and glycine to help maintain muscle. I've checked out the compound pharmacy on BeSafeRx and everything seems to check out as reputable.
Has anyone started on Wegovy then switched to a compounded formula of semaglutide and if so, what was the transition like and have you lost any weight?
Any info is appreciated.

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@lisalucier , thank you for the follow-up and link. I will spend some time looking at it in the morning.
After submitting my post, I reached out to The Bridge program to find out the specific reason I was denied and they couldn't tell me. I (do) have sleep apnea for which I'm being treated, so I'm guessing that's the cause although I do have 2 other qualifying conditions. I understand there are pathways for coverage through Part D for those who have disqualifying conditions so I reached out to Humana (my Part D carrier) to find out what those pathways are. Humana told me that my PCP (prescriber of Zepbound) should complete a "Formulary Exception" form and submit to Humana for approval and that might qualify me for Part D coverage. They were unable to tell me what my share of the cost would be if my exception was approved but hopefully would be less that the $450 I paid for the kwik pen. I shared Humana's response with my PCP yesterday but haven't heard back. I'm sure they are frustrated with this situation as much as I am and I am grateful for their help. I offered to do any leg work needed to make it easier for them if that is an option. Hopefully, I'll hear something soon.
Thanks again for checking in,
Barrett

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Profile picture for bhb30602 @bhb30602

@lisalucier Thanks for reaching out. I seemed to hit a plateau at a 12lb loss. My PCP prescribed Zepbound (15mg Kwik Pen) that I purchased from Lilly. I don't qualify for the Bridge program ($50 copay monthly) but I may have another option.
Healthwise, I tolerated the semaglutide without problems and so far, 2 does of the Zepbound have not given me any problems either.
If you know of, or can direct me towards resources that provide discounts for Zepbound I would appreciate you sharing those w me.
Thanks again - take care.
Barrett

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@bhb30602 - have you had the chance to look on the manufacturer's site for discount coupons, such as this page?https://zepbound.lilly.com/savings

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Unless your on Medicare there is a bridge program, otherwise some insurances may send a coupon to your pharmacy, still very high priced. I buy direct from Lily and pay 248.00

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Profile picture for Lisa Lucier, Moderator @lisalucier

@bhb30602 - just checking in to see how its going with your compounded formula of semaglutide?

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@lisalucier Thanks for reaching out. I seemed to hit a plateau at a 12lb loss. My PCP prescribed Zepbound (15mg Kwik Pen) that I purchased from Lilly. I don't qualify for the Bridge program ($50 copay monthly) but I may have another option.
Healthwise, I tolerated the semaglutide without problems and so far, 2 does of the Zepbound have not given me any problems either.
If you know of, or can direct me towards resources that provide discounts for Zepbound I would appreciate you sharing those w me.
Thanks again - take care.
Barrett

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Profile picture for bhb30602 @bhb30602

Thanks for checking in Lisa.
I've lost about 5-6 lbs total since beginning. I started out on 25mg sample of Wegovy from my PC, then moved to the compound the next month to the .50, then 1.0 the following month. This past week I started my 1.7mg dose and fortunately, still have not experienced any major side effects.
My PCP said this (1.7) dose but for sure the next dose (I believe will be 2.4 or 2.5 mg) will begin more weight loss. I'm walking 3 miles 3x p/week at a pretty good pace and drinking LOTS of water so I'm being patient. I've also noticed some consensus around the notion that the lower doses up to 2.5 are helping calibrate and prepare my body for the higher dose, and that they (lower doses) usually don't yield the best results.
Thanks again for reaching out - any thoughts to share are welcomed and appreciated.

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@bhb30602 - just checking in to see how its going with your compounded formula of semaglutide?

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Profile picture for loresull @loresull

Hello,

I tried wegovy last year and it didnt work like I hoped, since I am not diabetic my weight loss was slow and only like 15 to 20 lbs. I did lose mostly muscle and even fell and damaged my meniscus. After a year my weight loss was only like 20 lbs, which I gained back. I was thinking of trying a different one, it is called Zepbound (tirzepatide). any thoughts? this time I will be excersisng and doing yoga. I am hoping to lose aprox 30 lbs by december.

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@loresull
Hi there, I feel like I’m a professional dieter which gives you the story of all the weight loss I’ve done and weight gain. After gaining almost 80 pounds after an accident and being wheelchair bound for two years, I finally upped my exercise. My doctor sent me down and we figured out how many calories I needed to maintain the weight I was at then we removed 500 cal. He was kind of shocked that I needed to drive to 1000 cal to kickstart my system into losing weight. It’s not many calories so I had to make it extremely nutrient dense. Any grains or whole grains, I would marinate chicken and have chunks of it in a baggie in the fridge to grab for snacking or throw on a salad. Same thing with some steamed shrimp, etc. I would make a gallon baggie of salad with every vegetable I could think of and I ate that once my breakfast of one egg, one egg white and a little cottage cheese had passed. I didn’t eat anything else until that salad was gone and it really did get tiring, but it also filled me up and kept my system running. We’re all vegetables have lots of needed nutrients in them that we need to keep from getting depleted. I enjoyed a small medium potato, actually quite often because of the potassium. It’s a starch not a carb really .
Anyway, it took about three weeks before my body finally kicked in to weight loss and from that point on it was pretty easy. I did use protein bars occasionally and I would slice them up in 1/6 of a bar and keep them in the freezer. I’m an anxiety eater so I had to have food to munch on and I prepped cucumber chunks, celery, sticks, and anything crunchy like that to have on hand. It took me a year and a half to lose the weight but I have kept it off. I probably have about 1200 cal a day now. I can’t do a lot of exercising because of the damage from the boating accident which pretty much mangled my right lower leg. Long walks are out for me so is riding a bicycle but I can push a mean vacuum cleaner lol
Anyway, you have to find out how many calories you maintain your weight at then you’ve gotta remove 300 maybe to start and if it’s feasible remove 500 cal from your allowance then you will lose weight. I guarantee it. If I were to have had access to a GLP one at the time I would have used it absolutely but with the above. If you don’t change your behavior, you will just gain the weight back. Of the GLP ones I would certainly use Terzepitide compounded with B6. I think. Search out a good compound Pharmacy. Big Pharma has got these things so high priced under brand name. It cuts out most people. I helped my daughter and it cost us $50. Per 10 milligram units of Terzepitide. I mixed with sterile, prescription grade micellar water and all sterile syringes and protocols. She’s lost 20 pounds with the cost of $100.
I understand everyone’s concerns and FDA likes nothing better than to you into submission, but there are some great Terzepitide peptide resources available GLP 1 peptides reconstituted with sterile pharmaceutical micellar water is a game changer for those that can’t afford the big box and whose insurance doesn’t cover weight loss. It worked just the same as my friend who is using the brand pharmaceutical pens. Cost her close to $4000. But do your homework and be safe and good luck on your weight loss journey.

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Profile picture for 3oakley2 @3oakley2

I understand that totally. We have no kids but our girls are our family. We lost our 2 girls within months of each other..it was devastating. They are family. We waited almost 2 years to get another dog..then another so we have 2 girls again! That’s a normal grief reaction. Take your time and grieve the pups, no reason to hurry it. I can now laugh and smile and think of our girls but it took awhile..a long while. One was my heart dog, we called her.
Did your Dr give you something for nausea? Zofran helps a lot of people. I take my shot at night..10 pm maybe I slept thru it. I didn’t have nausea except a couple times when I ate too much like a whole steak…that was the last time. You will learn what you can and can’t eat anymore. I just felt like I had gorged myself at a buffet all the time. I would eat a couple bites and I couldn’t eat any more. I thought that is how these drugs worked, I thought everyone felt like that and that’s how you lost the weight. I couldn’t hardly get up and go places without being dizzy and faint from not eating. I talked my endo into reducing my dose and we have both been surprised that now I can eat with no problem and still no food noise or cravings. I get hungry once in awhile but I have been told hunger is not your enemy and it isn’t. Even if I’m hungry i don’t go crazy. The journey has been good for me. I am thankful for the compound because the starting dose pen I would have had to stop. I hope you can find a local compounding pharmacy if that’s what you choose. I was familiar with them because one of our pups had bladder cancer and the other one had kidney failure, they were small so we had to use compounded meds with them. As a nurse I was leery at first but I am very comfortable after using this since July of last year. I had no choice, my gastro said Do meds, surgery or die early. I wish you good luck! PS..I have just started into therapy after 21 years, trying to find other coping mechanisms, other than eating! Only my 3rd visit so hopefully it will help.

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@3oakley2 - I'm so sorry about the loss of your dogs. Wondering how you are doing with that and also with your compounded tirzepatide (Zepbound)?

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Profile picture for loresull @loresull

oh this is great news! i will let my endo know. i do snore like a trucker.... maybe i should have my husband record me!
tyvm!!!

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My husband, bless his little heart, recorded me snoring and stopping breathing so that’s what got me to the sleep study and a CPAP machine. But it always isn’t readily noticeable. The cardiologist was having a hard time regulating my husband’s BP and I asked him about a sleep study and yep he needed it but I had never and to this day have never noticed him stop and start breathing but it’s helped him tremendously. And sleep is when your body repairs itself. When menapausal some of us didn’t and don’t get good healing sleeps.

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Profile picture for 3oakley2 @3oakley2

A sleep study that your Dr can order. Snoring is a sign. Zepbound has been approved for treatment of obstructive sleep apnea now. That doesn’t mean that your insurance has to approve it you would just have to ask your insurance. Sometimes the insurances want you to do steps A, , and C before they give a PA..that’s a question you can ask them.

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oh this is great news! i will let my endo know. i do snore like a trucker.... maybe i should have my husband record me!
tyvm!!!

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Profile picture for 3oakley2 @3oakley2

I understand that totally. We have no kids but our girls are our family. We lost our 2 girls within months of each other..it was devastating. They are family. We waited almost 2 years to get another dog..then another so we have 2 girls again! That’s a normal grief reaction. Take your time and grieve the pups, no reason to hurry it. I can now laugh and smile and think of our girls but it took awhile..a long while. One was my heart dog, we called her.
Did your Dr give you something for nausea? Zofran helps a lot of people. I take my shot at night..10 pm maybe I slept thru it. I didn’t have nausea except a couple times when I ate too much like a whole steak…that was the last time. You will learn what you can and can’t eat anymore. I just felt like I had gorged myself at a buffet all the time. I would eat a couple bites and I couldn’t eat any more. I thought that is how these drugs worked, I thought everyone felt like that and that’s how you lost the weight. I couldn’t hardly get up and go places without being dizzy and faint from not eating. I talked my endo into reducing my dose and we have both been surprised that now I can eat with no problem and still no food noise or cravings. I get hungry once in awhile but I have been told hunger is not your enemy and it isn’t. Even if I’m hungry i don’t go crazy. The journey has been good for me. I am thankful for the compound because the starting dose pen I would have had to stop. I hope you can find a local compounding pharmacy if that’s what you choose. I was familiar with them because one of our pups had bladder cancer and the other one had kidney failure, they were small so we had to use compounded meds with them. As a nurse I was leery at first but I am very comfortable after using this since July of last year. I had no choice, my gastro said Do meds, surgery or die early. I wish you good luck! PS..I have just started into therapy after 21 years, trying to find other coping mechanisms, other than eating! Only my 3rd visit so hopefully it will help.

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Thank you for understanding, my doggies are my life. we did everything for them and yes it is uber devastating, i still find myself crying and not able to deal. i so thankful for my kittie Ellie, we rescued her last year, i now think it was a sign, she is here to help me thru this horrible loss. Both our doggies also had cancer. she had spleen and he had pancreatic.
I do have zofran, thank you for the reminder. I will take it next time i have that horrible feeling.
We bought protein shakes from costco and they have been a huge help, since I am also a vegetarian and do not drink milk we found some that are vegan and help when im in a rush.
i have been thinking about therapy, ive done it before for childhood ptsd maybe i need to revisit. good luck w therapy, please keep me posted!!! it gives me hope!!! i keep repeating time heals. its going to be a year in october for Isabella and i'm so not ready.

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