Started Repatha - Side Effects

I have just started Repatha. My dose is 140 mg/ml every two weeks. My cardiologist wants to reduce my LDL to 70. I found I cannot tolerate the side effects of statins - tried several different varieties and doses. I joined to see how others are doing with this medication. I am also wondering if others have found taking the rx once a month instead of every two weeks is effective.

@desertdwellerjh I did the same thing. Couldn’t tolerate statins and tried Repatha. At first I thought it would be ok, but it proved as bad as statins. I tried red yeast, also had statin side effects. Tried plant sterols. No effect on my numbers. I am right now doing Terzepatide. I’ve been on it for about 3 months. After it’s been 6 months I’ll test again. I don’t have side effects, but I am very careful to eat healthy foods to prevent constipation.

I started Repatha 3 doses back. Won't be a 4th. First 2 unremarkable. I started to get optimistic thinking this may work. Short lived optimism. After the 3rd injection (140 ml) flu like symptoms, BP became higher, (and remains high) and the worst was mood swings, nervousness and not myself. I'm in excellent health, I row every other day, very good diet. MET score of 17.2 in march, stent in LAD. Yes the numbers were great, 104 TC, 37 LDL. However I cannot in good sound conscious do the 4th injection. Never in my life other than dealing with grief have I ever had mood swings. I see my cardiologist Thursday. Could not take traditional statins as they caused neurocognitive events. The Repatha was worse. I have no inking as to how I will proceed going forward. For those of you who can tolerate this medication you are very lucky as it is effective, however when you quality of life is this disrupted its not a difficult decision...

Same here only my cardiologist was not sympathetic as though it’s was ok to be bed ridden and impaired as long as my chlorestrol was low. I tried red yeast, same symptoms. Plant sterols, didn’t work. Semiglutide, way too nauseated. I’m right now on Terzepitide with no side effects. I will do labs in another 3 months. 🤞🏻

@johnjtgg PS. I also am very active, eat healthy foods and I’m not overweight, have low normal blood pressure. The only meds I take are for thyroid.

I think another overlooked side effect is BP rises on Repatha, especially if you have hypertension. After reading many of the comments I'm mad at myself for not doing my due diligence in researching this medication out more thoroughly...

Don’t feel bad, Cardiologists are pushing it.

@johnjtggI think one of the issues for Repatha is that it is relatively new and more studies need to be done. Currently, it seems that few side effects are listed or if they are, providers assume they are quite rare. Good luck with your situation and let us know what is suggested.

@backhand with my Cardiologist all that mattered was lowering chlorestrol numbers. He actually got giddy when mine lowered. He acted like my side effects were faked and was displeased when I had to quit taking statins and Repatha. It’s like his only goal was numbers. When asked what else I could do, diet, exercise and he said “I have nothing for you.” I want to live a long healthy active life and I’m willing to discipline myself. Taking those drugs caused me to lie in bed in misery. A shorter happy active life is better than that!! I didn’t go back to that cardiologist. I don’t even have a cardiologist at this point.