1. < Polymyalgia Rheumatica (PMR)

Low Dose Naltrexone and Prednisone for PMR?

Posted by pkalkstein @pkalkstein, Mar 1, 2023

My doctor has prescribed LDN and I will be receiving it soon from a compounding pharmacy. I am tapering prednisone, now at 12.5 (from 20 over 4 months) with no pain, although I can feel that PMR is still active. From what I have read, I plan to take 1.25mg of LDN at night, and 10 mg prednisone in the morning, slowly working the LDN up to 4.5 and the prednisone down as reasonably quickly as I can without a flare. Has anyone tried a similar formula? Any advice would be welcome, and of course I will report developments.

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khbarratt | @khbarratt | May 13 1:21pm

Has anyone had experience with purchasing LDN through AgelessRx? I just applied for it through them. I'm awaiting approval. I hope I get it, because I was on Leflunomide to taper off prednisone, but had to stop due to GI issues. Now I'm having flare-ups because I'm only on 5mg per day. I really don't want to up my prednisone dose. My insurance company would not approve Actemra Actpen 162mg/0.9ml Soaj. My rheumatologist isn't returning my calls and hasn't given me any new appointments. I just made an appointment with a Rheumatologist with the medical group my PA is in, but they booked me one year out.

REPLY
1 reply
smoore6480 | @smoore6480 | May 15 1:52am
In reply to @khbarratt "Has anyone had experience with purchasing LDN through AgelessRx? I just applied for it through them...." + (show)
@khbarratt

Has anyone had experience with purchasing LDN through AgelessRx? I just applied for it through them. I'm awaiting approval. I hope I get it, because I was on Leflunomide to taper off prednisone, but had to stop due to GI issues. Now I'm having flare-ups because I'm only on 5mg per day. I really don't want to up my prednisone dose. My insurance company would not approve Actemra Actpen 162mg/0.9ml Soaj. My rheumatologist isn't returning my calls and hasn't given me any new appointments. I just made an appointment with a Rheumatologist with the medical group my PA is in, but they booked me one year out.

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I have used them now for 4 months. No issues. Reorders have been easy

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tsharkey01 | @tsharkey01 | May 18 9:45am
In reply to @pkalkstein "LDN had no discernable effect on my PMR, although it cured my neuropathy and sciatic pain." + (show)
@pkalkstein

LDN had no discernable effect on my PMR, although it cured my neuropathy and sciatic pain.

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Did your neuropathy come back after you stopped taking it ?
I took LDN for 2 weeks and the neuropathy went away but now 6 months later it’s back.

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pkalkstein | @pkalkstein | May 18 11:58am

I stopped for several months and it did not come back. I have started half-doses so as not to take a chance, as the neuropathy was horrendous.

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