Low Dose Naltrexone and Prednisone for PMR?

Posted by pkalkstein @pkalkstein, Mar 1, 2023

My doctor has prescribed LDN and I will be receiving it soon from a compounding pharmacy. I am tapering prednisone, now at 12.5 (from 20 over 4 months) with no pain, although I can feel that PMR is still active. From what I have read, I plan to take 1.25mg of LDN at night, and 10 mg prednisone in the morning, slowly working the LDN up to 4.5 and the prednisone down as reasonably quickly as I can without a flare. Has anyone tried a similar formula? Any advice would be welcome, and of course I will report developments.

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

pattiobrien111 | @pattiobrien111 | Mar 17 4:04pm

In reply to @denzen "Great to hear of your success with LDN. Can you tell me where I can find..." + (show)

This is a good article on how and why LDN works including the dosing which is 1-4mg gradually.
Best Wishes.
https://www.iddoctor.eu/docs/LDN-Rx-2012.pdf

pattiobrien111 | @pattiobrien111 | Mar 17 4:05pm

In reply to @denzen "Great information. I've been looking into LDN as well. Would you say where you learned the..." + (show)

Here is an excellent article.
https://www.iddoctor.eu/docs/LDN-Rx-2012.pdf

denzen | @denzen | Mar 17 4:57pm

In reply to @pattiobrien111 "Here is an excellent article. https://www.iddoctor.eu/docs/LDN-Rx-2012.pdf" + (show)

Thank you so much for your reply, Patti and Happy St. Pat's Day.

denzen | @denzen | Mar 17 4:59pm

In reply to @megz "There are updates on how pkalkstein assessed the use of low dose naltrexone for PMR, with..." + (show)

I really appreciate your response. Thank you.

shelltown55 | @shelltown55 | Mar 18 12:53pm

I started LDN and week 1 at 1.5 mg had significant reduction in pain and spasms. It doesn’t mess up the body like other drugs yet decreases inflammation!!! Can wait for 3 mg might last all day!

allywit | @allywit | 3 days ago

In reply to @pkalkstein "Thanks for asking,@redboat. I am not being tested regularly. No CRP number since first diagnosis in..." + (show)

Can you update on how LDN worked out for PMR? Thank you so much
Ally

megz | @megz | 2 days ago

In reply to @allywit "Can you update on how LDN worked out for PMR? Thank you so much Ally" + (show)

There are updates on how pkalkstein assessed the use of low dose naltrexone for PMR, with limited benefit for PMR but possible benefits for other ailments.
https://connect.mayoclinic.org/comment/1116790/