JAK2 negative with high platelets

Posted by mgrimes5 @mgrimes5, Oct 22, 2020

I have been told that my JAK2 results came back negative, which I think is a good thing, but my platelets continue to run over 800. I haven’t been diagnosed with anything, but what could these somewhat contradictory results mean?

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Good morning,
Has your spleen been removed?


Hi @mgrimes5, I's like to welcome you to Mayo Clinic Connect. You came to the right place to seek possible causes of high platelet count with a negative JAK2 test.
I know that @shenriq and @mjpm2406 had positive JAK2s but perhaps they can lend some insight on what their physicians tested for prior to finding the mutation.
@mgrimes5 has your physician checked for an infection, anemia or low iron?


Hi @mgrimes5, wondering how you are doing and if your physician has followed up at all yet?


Myself, platelets getting higher, was told I have JAK 2 mutation – clueless as to what determined the JAK 2 diagnosis – I have the blood work print out.
Values look fine. For the Platelets he said to take an aspirin daily and see him in 6 months. Doctor is an Oncologist Hematologist. .

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