I've been on the same dosage (225mg) of Effexor XR for a few years now. Other than a few times when I slept in and took my meds late, I have never experienced this before. It's been 4 days now that I'm getting withdrawal symptoms (brain zaps like crazy etc.). I haven't stopped taking my meds though. I've been on the hunt because it's driving me crazy. Only variables that are different is the fact that I've caught either a bacterial or viral infection and have had a fever for a few days, or my home made remedy of ginger, tumeric, honey, lemon and pepper that I've been drinking to naturally ease the fever, inflammation and kill the bad stuff. Just wondering if anyone else has experienced this or knows of any reasons one would stop efficiently absorbing the daily dose.