Has anyone experienced fatigue while taking Mirtazapine 30mg?

Yes, it is a definite side effect. I was on mirtazapine 30 mg. years ago & at that time a life savior for me.
I had suffered a very traumatic event and could not sleep or eat (or do anything really). However I was not hospitalized. After lots of trial and error with other SSRIs it was this drug - a SNRI - that help me sleep and gave me an appetite. However, be aware...this drug can/will caused major weight gain along with increased lipid profile and triglycerides. Eventually I had to go on the statins, my cholesterol, etc. became so high. But I needed this medication at this time in my life - it was the only medication that returned me to a "normal" life and I was able to go back to work, etc. & become fully functional again.
I took it at 9 PM nightly. In time, if you are on it for "long" term your body will eventually adjust to it and your fatigue will not be so pronounced.
Hope it is helping with your depression. All the best!

Thanks for your reply. I also take Wellbutrin which helps to control the weight gain.

I’ve been on Mirtazapine for a long time now, and I do experience fatigue during the day - but I have chronic fatigue syndrome, so not sure how much of it is related to the Mirtazapine. I have to take it for chronic insomnia. I have not experienced weight gain or elevated lipids, but I take over 20 prescribed meds, so they may be helping prevent those issues.

@briarrose I take it for sleep , specifically! It also helps me with my anxiety and depression.

Do you take 30 mg?