Brinsupri (aka Brensocatib)

Just spent one week at National Jewish Health and being prescribed Brinsupri - Dr taking care of paperwork and getting insurance approval. So excited. Will post later about my incredible journey with NJH.

For those that are starting on Brinsupri, are you currently on MAC drugs?

Here is the summary for those who are interested:
https://connect.mayoclinic.org/discussion/brinsupri-brensocatib-webinar-summary/

I too will be starting Brinsupri on 9/5/25. Although my Mayo Jax Pulmonologist told me they had access to it and will get it for me, my Pulmonologist in Vermont (UVM) had already made the arrangements and received insurance approval 3-5 days prior to Mayo. I’m excited to try it, although Dr. O’Donnell said in a recent Webinar you may not see or feel a difference for 24 weeks or more according to the clinical trial results. But as we all know with nothing else to treat our NCFBE, it’s well worth trying for me. I will definitely keep everyone updated as time goes on.

I do my second nebulizing also before bed and I am sleeping better since I started that. It worked for me. HOWEVER, when the bladder needs me to walk down the hall I have to do a bit of clearing before putting my head back on the wedge pillow. I hope to be able to say in the near future that my sputum is "quite clear"....I feel it is a bit cloudy. Glad you shared your new schedule. I like the before bed nebulizing because it gives me a longer period of time to do other things after the A.M. treatment.
Barbara

Sue,

I am interested in knowing about any known or potential side effects. The most concerning thing that I've read about is gum/teeth issues, which I find very disturbing. Any concrete insight would be most helpful.

Thank you.

Those on the placebo had more gum periodontal issues than those on the actual drug. Go figure. Aging.

I am not an expert on this med, or its possible side effects. When the recording from the webinar comes out it has a little information on the side effects, but as @scoop pointed out, perio effects were seen just as much in the placebo group.

In my personal situation, I think a 20-25% reduction in exacerbations is not sufficient to try a brand new, expensive drug that has not been tested on people with other health issues.

I only provided the summary because I had the opportunity to hear the webinar. At this point, I won't be doing any more research on Brinsupri until there is much more history of people with RA and coronary artery disease using it safely.

No one is mentioning the most common adverse reaction being upper respiratory infection. For me that would be a very big concern as I have that going on chronically already.

I don’t have Medicare Part D. I wonder how much it is without. ??

I thought I was healthy when I started Medicare.