B-6 vitamin danger!

Posted by Lynsorensen @lynsorensen, Dec 11, 2017

With the assistance of a neurologist at Mayo Clinic, I have almost completely eliminated the uncontrolled muscle spasms now. First and foremost: beware of taking multi-vitamin capsules that have B6 listed. B-6 overdosage (which is contained in every multivitamin I found in stores and on the internet) can cause loss of muscle control and spasms in some people. So can gluten found in many foods so now I am also gluten free. I now work out with a personal trainer 3 days a week and do water aerobics another 2 days. Got off gabapentin and also clonazepam. Using CBD oil capsules each morning (no more opioids or chemicals) and using a CBD topical ointment to rub on my leg muscles each night. He says I don’t need him anymore! And I don’t. No more shaking or muscle cramps or pain. Still a little numbness but that is receding also.

@peggyn

WISFLOJ Do you remember what your b-12 was. Mine is 2,000 .,but no one says it's too high although it's not in the range.

Jump to this post

@peggyn the last time my B12 level was checked it was around 1244 but it has been over 2000 but I don't think it's a cause for concern. There's a lot of good information on B12 here:
https://www.easy-immune-health.com/vitamin-b-12-deficiency-symptoms.html

REPLY
@johnbishop

Hello Joseph @jhkeffer, Welcome to Connect. Thank you for sharing how B6 toxicity affected your wife. It's great to hear that discontinuing the multivitamins made a difference. Most people don't understand the impact and just think it's only vitamins…vitamins are good for you. A person really has to be their own advocate and learn as much as they can about their health. It's awesome that your wife has her own live in doctor who can be her advocate. Thanks again for sharing on Connect.

There is another discussion on Connect that you may be interested in (just in case).

> Groups > Neuropathy > Burning Feet syndrome
https://connect.mayoclinic.org/discussion/burning-feet-syndrome/

Jump to this post

I have severe, painful neuropathy in feet, legs, hands, arms, and mouth. I have also been tested for B6, and have high levels (around 80 ng/ml). I stopped taking a multivitamin with B6 last October 2018 when I first tested high for B6, but my levels have not decreased. Does anyone know how to lower your B6 levels. I don't eat much red meat or any other food that has high B6 that I know of.

REPLY

Vitamin B12 is an essential vitamin present in foods from animal sources such as eggs, cheese, milk, yogurt, and meats. Perhaps vegans are more at risk for vitamin B12 deficiency. Pernicious anemia is a result of not enough vitamin B12. The Shillings test can be used to determine if someone has pernicious anemia.

REPLY
@cwallen9

I have severe, painful neuropathy in feet, legs, hands, arms, and mouth. I have also been tested for B6, and have high levels (around 80 ng/ml). I stopped taking a multivitamin with B6 last October 2018 when I first tested high for B6, but my levels have not decreased. Does anyone know how to lower your B6 levels. I don't eat much red meat or any other food that has high B6 that I know of.

Jump to this post

@cwallen9 here are a couple of references I've found for how to lower B6 levels. You might already be doing some of them but maybe there is some tips that will help.

Livestrong.com – How to Lower B6
https://www.livestrong.com/article/522968-how-to-lower-b6/

Detox From Dangerous Supplements and B6 Toxicity
http://www.drorestesg.com/blog/detox-from-dangerous-supplements-and-b6-toxicity-

Linus Pauling Institute » Micronutrient Information Center B6
— Food sources of B6: https://lpi.oregonstate.edu/mic/vitamins/vitamin-B6#food-sources
— Fact Sheet for Consumers: https://ods.od.nih.gov/factsheets/VitaminB6-Consumer/

REPLY
@peggyn

WISFLOJ Do you remember what your b-12 was. Mine is 2,000 .,but no one says it's too high although it's not in the range.

Jump to this post

Initially it was low at 383. I then started 2000 mcg. Daily of methylcobalamin and it went up to 1740. Per my dr. I then reduced my B12 to 1000 mcg. per day and it is now 865. My bloodwork lists the range as 200 -1100

REPLY

Hello. I have bad bilateral sensory neuropathy in feet and ankles for eighteen years. I recently learned that I have a non-conservative mutation in my SDHB gene (which is responsible for a pheochromocytoma I had many years ago). For years, I've had elevated serum B6 even though I don't take B6 supplement. Could the mutated SDHB gene be responsible for my elevated B6 and/or neuropathy? Many thanks for àny clues.

REPLY
@margaret10

Hello. I have bad bilateral sensory neuropathy in feet and ankles for eighteen years. I recently learned that I have a non-conservative mutation in my SDHB gene (which is responsible for a pheochromocytoma I had many years ago). For years, I've had elevated serum B6 even though I don't take B6 supplement. Could the mutated SDHB gene be responsible for my elevated B6 and/or neuropathy? Many thanks for àny clues.

Jump to this post

Hello @margaret10 — Welcome to Mayo Clinic Connect. I'm hoping other members may be able to help you with your search. It is good to be learning as much as you can about your condition. Here are a few articles I found that may be helpful.

Disorders affecting vitamin B6 metabolism — https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.12060
Elevated B6 Levels and Peripheral Neuropathies — https://pubmed.ncbi.nlm.nih.gov/18754531/
Linus Pauling Institute – Vitamin B6 — https://lpi.oregonstate.edu/mic/vitamins/vitamin-B6

Have your doctors suggested any possible treatments for your elevated B6 levels?

REPLY

Also be cautious about taking Turmeric supplements as they raise B6 levels. I was taking them for SFN until the neurologist told me how potentially dangerous they were in terms of B6 toxicity.

Liked by rwinney

REPLY
@ruthofanne

Also be cautious about taking Turmeric supplements as they raise B6 levels. I was taking them for SFN until the neurologist told me how potentially dangerous they were in terms of B6 toxicity.

Jump to this post

Please provide the name of the neurologist that told you that turmeric supplements can cause B6 toxicity, or a citation to a publication that says the same. Thank you.

REPLY

@margaret, I read online that tumeric contains 0.122 mg. of B6 which I think is negligible. Just FYI Helen

REPLY

I was taking 500 mg of turmeric and my vitamin B6 levels shot up. I only saw this neurologist once quite a while ago and he adamantly told me to stop the Turmeric because it elevates Vitamin B6 levels. He did not give me any further information because this was one of those 5 minute appointments that are meaningless I no longer see him and his name has slipped my mind.

REPLY

I eat a healthy diet that is high in foods that contain vitamin B6 and also some of the other B vitamins. I don’t need to take anything else.

REPLY
@johnbishop

Hi @gman007 – I agree that each person should discuss with their doctor before taking a lot of any vitamin/supplement. If there is any question, it’s always a good idea to discuss it with your doctor or a pharmacist and know what you are taking. The problem with B6 is that it is different than other B vitamins when it comes to being water soluble. Unlike most B vitamins, B6 does not simply wash out of your system in the urine. So if you have a health problem that’s affecting levels of B6 in your body and you take multivitamins and other supplements with a lot of B6 in them it can lead to B6 toxicity and cause a lot of healthy issues – one being peripheral neuropathy. I don’t have any medical training or background but know this through research and others who have been affected by high levels of B6 in their system.

John

Jump to this post

Hello John. Thanks for this info. Before I ask my doc to run some labs, what other than B6 should I have checked? Only things that are related to neuropathy please. I've had a lot of things checked due to a lot of weight loss and for other reasons. Thanks so much and warm regards, Sunnyflower

REPLY
@sunnyflower

Hello John. Thanks for this info. Before I ask my doc to run some labs, what other than B6 should I have checked? Only things that are related to neuropathy please. I've had a lot of things checked due to a lot of weight loss and for other reasons. Thanks so much and warm regards, Sunnyflower

Jump to this post

Hi @sunnyflower, I have no medical training or background and would leave that to your neurologist. Here's some information I found that identifies some of the vitamin deficiencies that can cause peripheral neuropathy.

Peripheral Neuropathy Due to Vitamin Deficiency, Toxins, and Medications: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208100/

Hope this helps!

REPLY
@johnbishop

Hi @sunnyflower, I have no medical training or background and would leave that to your neurologist. Here's some information I found that identifies some of the vitamin deficiencies that can cause peripheral neuropathy.

Peripheral Neuropathy Due to Vitamin Deficiency, Toxins, and Medications: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208100/

Hope this helps!

Jump to this post

Hi John, thanks so much! Warm regards, Sunnyflower

REPLY
Please login or register to post a reply.