Anyone have experience with Dupixent for asthma?

Posted by kspowell @kspowell, Aug 18, 2022

Does anyone have asthma and experience with the monoclonal antibody Dupixent and would share pros and cons?

Thanks!

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Yes! I have a rash in my face, can’t really see but feels rough like sand paper. Also as soon as I get the shot I lose my voice. I have a hard time having a conversation. My doctor said give it time but it’s been 6 months. I don’t feel like the Dupixent’s has helped at all only caused issues. And now I have conjunctivitis in both eyes.

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Thank you! So sorry for the trouble you are having as well. I hope you find something that works better for you. I see my Doctor Wednesday and I think I am going to stop taking it as well.

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Profile picture for sunnydaysatlast @sunnydaysatlast

Thank you! So sorry for the trouble you are having as well. I hope you find something that works better for you. I see my Doctor Wednesday and I think I am going to stop taking it as well.

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Wish you the best as well. Has anyone hear of Yupelri?

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I've been on Dupixent for about a year with no side effects

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My PCP is recommending that I try Duplixent, which is described as follows: Dupixent (dupilumab) is a biologic medication used to treat various inflammatory conditions such as eczema, asthma, and chronic rhinosinusitis with nasal polyps. It is given as a subcutaneous injection and works by blocking two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), that contribute to inflammation.I have high eocinophil levels and asthma, which are indicators that this drug will work. It's only recently been approved by the FDA, so I'm wondering if others have had a chance to try it yet.

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Profile picture for sungal @sungal

My PCP is recommending that I try Duplixent, which is described as follows: Dupixent (dupilumab) is a biologic medication used to treat various inflammatory conditions such as eczema, asthma, and chronic rhinosinusitis with nasal polyps. It is given as a subcutaneous injection and works by blocking two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), that contribute to inflammation.I have high eocinophil levels and asthma, which are indicators that this drug will work. It's only recently been approved by the FDA, so I'm wondering if others have had a chance to try it yet.

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I only have mild asthma, but started Dupixent with loading dose for another condition 2 weeks ago. I'd had a sample dose 5 weeks before. They ship them to me and I self inject. Was tired first evening, but ok and no issues. I do get red area at injection site for 24 hours. It's helping. I have only mild asthma that is coughing, not wheezing, and it rarely causes issues for me.
I'm not sure if that's what you're looking for.

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Profile picture for sungal @sungal

My PCP is recommending that I try Duplixent, which is described as follows: Dupixent (dupilumab) is a biologic medication used to treat various inflammatory conditions such as eczema, asthma, and chronic rhinosinusitis with nasal polyps. It is given as a subcutaneous injection and works by blocking two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), that contribute to inflammation.I have high eocinophil levels and asthma, which are indicators that this drug will work. It's only recently been approved by the FDA, so I'm wondering if others have had a chance to try it yet.

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Mostly, I'm worried about side effects, and you sound as though you haven't had major side effects. That's reassuring. Thank you!

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Profile picture for sungal @sungal

My PCP is recommending that I try Duplixent, which is described as follows: Dupixent (dupilumab) is a biologic medication used to treat various inflammatory conditions such as eczema, asthma, and chronic rhinosinusitis with nasal polyps. It is given as a subcutaneous injection and works by blocking two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), that contribute to inflammation.I have high eocinophil levels and asthma, which are indicators that this drug will work. It's only recently been approved by the FDA, so I'm wondering if others have had a chance to try it yet.

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I’ve been on Dupixant for a year and half. Not noticed side effects. It allowed me to wean off the nebulizer. I took about 6 months to notice the change. I am and have been asthmatic since birth. I currently use strongest dose and self inject twice a month.

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Profile picture for pacathy @pacathy

I only have mild asthma, but started Dupixent with loading dose for another condition 2 weeks ago. I'd had a sample dose 5 weeks before. They ship them to me and I self inject. Was tired first evening, but ok and no issues. I do get red area at injection site for 24 hours. It's helping. I have only mild asthma that is coughing, not wheezing, and it rarely causes issues for me.
I'm not sure if that's what you're looking for.

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Hi pacathy it's Barbara from the BE blog. We may have discussed it also on the BE blog when I posted it as a heading. I will be interested in knowing all the positive changes you experience. My concern, if I remember correctly, is that some people have an increase in inflammation with it. Have you heard that????
Barbara

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Profile picture for sungal @sungal

My PCP is recommending that I try Duplixent, which is described as follows: Dupixent (dupilumab) is a biologic medication used to treat various inflammatory conditions such as eczema, asthma, and chronic rhinosinusitis with nasal polyps. It is given as a subcutaneous injection and works by blocking two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), that contribute to inflammation.I have high eocinophil levels and asthma, which are indicators that this drug will work. It's only recently been approved by the FDA, so I'm wondering if others have had a chance to try it yet.

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I have been asthmatic since age 4 (now 62 yo). I was on Xolair - the very first biologic, for 15 years until it stopped working. I was changed to Tespire - to which I had bad reactions and wound up worse and hospitalized (it only worked for 6 weeks). I have been on Dupixant (about 2 years) which has made a terrific difference in my life. Yes, it took a while for it to start working, but it has allowed me to decrease prednisone - as I am steroid dependent for my asthma. I self inject every 2 weeks. I do get redness at the injection site and used to get tired for the first 1-2 days. I do notice some increased asthma about 2-3 days prior to the next injection - but that goes away a day after the Dupixant. I have had fewer major asthma attacks which require hospitalization. However, I am blessed to have a great supportive family, and a wonderful pulmonologist.

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