Anyone have experience with Dupixent for asthma?

In my online research I found that there are some ongoing law suits against the company that produces dupixent. The law suits claim the company didn't inform patients of the danger that dupixent may cause a rare type of lymphoma.

Thanks for the information.
Usually I turn down medications due to the possible side effects or if something hasn't been out for 20 years. Fortunately I haven't had an illness until my 79th year that required long term medications or medications at all and that is not a typical "medication". It is the hypertonic saline solution for Bronchiectasis.
So considering all I have learned since learning about Dupixent I will not venture into it for now since overall I have been controlling the two chronic health problems from getting worse, so far. I'll just keep doing what I am doing, eating healthy, low movement exercise, Vitamin D and other supplements like Vitamin C etc, the prescribed therapy for Bronchiectasis and moisturizing for the Eczema.
Barbara

Something you may consider adding it Magnesium Glycinate. Magnesium is good for asthma/respiratory problems and glycinate is the best form which is absorbed by the body. Remain hydrated - especially for bronchiectasis - as medically permitted. (Many congestive heart failure patients need to limit their fluid to 1.5 liters per day.) If necessary, ask your provider about a vibration vest, to help with loosening the secretions when it gets very bad. For bronchiectasis, it is also helpful to lower your head of bed (with legs higher), as the gravity helps the secretions to get out of the body. Good luck.

I have emphysema & brochiectasis. I was on Fasenra successfully four years until my pulmonologist wanted me to try Dupixent. In those four years my eosinophils got to zero but I still developed those lung diseases (I am newly diagnosed). Immediately after my first Dupixent dose I had severe head & neck pain. I suffer from these anyway due to cervical stenosis & I struggle with inflammation so believe Dupixent caused the severe inflammation. I stopped Dupixent at that time. My daughter, who has my same underlying genetic lung condition, is on dose five of Dupixent (after four years on Xolair). She has done very well, is prone to severe viral infections, and she will continue ad the Dr says Dupixent is her #1 biologic for people like her who struggle with infections.

A word of caution on lowering head of bed-if there's a hint that people have reflux, they should have head of bed elevated since reflux could introduce bad bacteria, like MAC, into lungs. It's a more common issue than you'd think.

Thank you pacathy - yes, you are right - if there is reflux head of bed down could cause more reflux or aspiration. I was thinking if only the person had bronchiectasis (without reflux). If one cannot tolerate or head of bed lowered is not good for that person - a vibration vest may be a good solution to wear during daytime, to help with the secretions.

Just saw this...I have seen the info about the rare cases of paradoxical inflammation like joint pain, conjunctivitis, eosinophilia, etc.

I've only had the loading dose plus one and just have the redness at injection site which resolves in day or 2. I had it sometimes with xolair, too. With dry eyes already, I was concerned about conjunctivitis and am using OTC drops.

I looked at studies on the cases of lymphoma in asthma patients, too. There's a recent study by KSK Ma in European Resp. Journal. They confirmed association , but still found "Dupilumab was also associated with significantly lower all-cause mortality."
I'll have to make sure I get periodic skin checks and keep eye out as more data comes in.

Yesterday at Primary Care Doctor visit I asked him to look in my ears, nose throat. We lost sight of the nose, throat but did the ears. He indicated the right ear O.K see right through....left ear inflammation showing. I made an appointment just now with the ear doctor.
This inflammation is something else and needs close watching by many specialists it appears.
Barbara

I have tried all FDA approved biologics for asthma. I highly recommend you do some extensive research on Dupixent before you agree to try it look at NIH research and clinical studies & some of the major research hospital such as Cleveland and Mayo. If you dig deep, you will find that there are “rare” cases of seronegative arthritis (RA), squamous cell carcinoma, thyroid cancer, etc. associated with Dupixent. Unfortunately, I have had all 3 of these rare occurrences, and have undergone more than 18 surgeries since 2020 to include thyroid cancer surgery, squamous cell carcinoma with MOHs, and double total knee replacement due to seronegative rheumatoid arthritis in the beginning and now I have seropositive. I was recently diagnosed with broncheatasis with aspergillus fumigatus and pseudomonas aeruginosa colonized in my lower respiratory tract due to suppressed immune system which is exactly what biologics do. In my opinion, Dupixent is by far the biologic with the most horrific side effects. I was ignorant and trusting of my pulmonologist at the time, but I have found they do not do the research themselves and rely on FDA, pharmaceutical companies and pharm sales for information. Best of luck.

I am on my third dose of Dupixent. My hands hurt as well as my back and shoulders. I do believe the pain is now moving to my legs. My muscles are getting weaker as it is getting hard to climb steps. Is anyone else having these issues?