Does anyone have asthma and experience with the monoclonal antibody Dupixent and would share pros and cons?
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Have you been told that your asthma is caused by a problem with eosinophils? Okay, that's why my husband takes Dupixent. It also cleared up his skin. Before the Dupixent, we would make visits to the ER, and he was admitted one time and he was intubated which was scary because I was told he might not be able to be taken off of it.
He injects himself with the Dupixent every other week and had no problems. He can breathe so much better and can do projects and walk across a parking lot without gasping and needing to sit down. No more ER visits.
My daughter has severe eosinophilic asthma, and has been using Dupixent for several years now – what a blessing it has been. She used to be hospitalized 2-3 times a year for asthma attacks that did not repond to nebs, but not a single time since the injections. She started bi-weekly and is now using it once a month. This is in addition to an inhaled combo med – Symbicort.
Here is a humorous side – she is an RN, who gives injections all day long, and for the first several months, she could not bring herself to do her own injections! She would bring the syringe to Dad (retired EMT) or sis (also an RN.) One time, neither was available, so she had to do it herself, now it's no issue.
I hope these two responses help ease your mind.
I have severe allergic asthma. I was on Xolair for 12 years with mixed results. I do not have eosinophilia asthma. In 2020 I started on Dupixent. The first 6 months I had more noticeable allergy symptoms and my chronic cough was worse but once my body got used to the medication I have done really well. I have required my controllers inhaler and a second steroid inhaler. I have been on this regimen since 2008. I have been able to ween off of that additional steroid inhaler this summer. Previously I haven’t been able to get below 2 puffs of that inhaler. I would say my results have been fantastic I still have asthma and some symptoms but it is controlled better than it ever has been before. My Mayo pulmonologist also feels if I have a flare up it should resolve with a few days of steroids. Previous flare ups required months of steroids and most times IV steroids.
I have asthma, allergies, hypothyroidism and some skin issues. My allergist is recommending I take the biologic Dupixent. Specifically I think she is getting it approved becasue of my nasal polyps and prior sinus surgeries. She says there are virtually no side effects or downsides. Has anyone had experience with this drug? I would appreciate any input anyone has. Thanks!
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Dupixent has done a great job. Try it.
How long have you been in it? Any side effects? Thanks!
I have been using Dupixent for over a year to treat eczema and asthma. It's been working for both conditions. I haven't had to use my inhaler much at all. I had no side effects. It's definitely worth trying. Good luck!
My allergist is recommending Dupixent for my nasal polyps. Has anyone had experience taking Dupixent? I would love to hear your reaction
Hi Sue — I usually post over on the Bronch/MAC forum and you are so helpful over there!!
So was surprised to see you here my first time as I am so frustrated having dealt with bronch and MAC and now just found out I also have Eosinophilic Asthma. Sigh…..
I’m 71 and never had asthma before and my MAC or bronch has not caused real problems for 15 years, but last September I was hospitalized twice with bad infections and serious breathing problems and now have e-asthma. My eosinophils are at 7% so not extremely high and my igE is a bit low which apparently is indicative of this also.
Besides the nebulizing saline and levabuterol for Bronch, I’ve been treated for a year now nebulizing Budesonide .5 twice a day which has kept things pretty stable but my doc is suggesting I switch to Dupixient which I knew nothing about, so your experience is really helpful, as I’ve learned to trust and value your always helpful and informed info!!
Is your daughter able to stay off inhaled steroids?
Hi – Wow, I was chatting with my daughter on the phone when this message popped. The good news is that her asthma is now controlled without inhaled steroids except during an exacerbation (as from allergies or a cold.) Then she uses a nebbed budosenide for a few days. The very best thing has been ZERO hospitalizations for asthma – a record since she started Dupixent – after 20+ years of multiple stays for many years.
By the way – she was also diagnosed with mild bronchiectasis after Covid – they don't know if it from that or her RA. At least she has never had MAC or pseudomonas!
If my asthma was diagnosed as eosiniphilic, I would try Dupixent without hesitation.
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