Neuropathy Pain at Night: What helps?

What’s the best medication for neuropathy that starts at night with feet and legs?

@emilyandersontarr Hi Emily. I have the exact same problem but have never had a solution. Hopefully, some of the Connect members will respond to our dilemma.
The one thing I've done to ease the problem is to raise one leg at a time while lying in bed and GENTLY massage the calf in a downward direction for a minute or two.
I then place the foot of that leg over the knee of the other leg, (which is bent at the knee to support it), and again GENTLY massage the calf of the leg that's resting on your knee. I say "gently" massage because medical advice warns against too vigorous massage of the calf for fear of breaking loose a clot that could cause a stroke.
Gosh, this sounds complicated as I read it over. It's hard to explain in words!
Anyway, Emily, this helps me so I hope it might help you too. I can usually get to sleep afterward.
P.S. I sometimes gently rub lotion or Voltaren on each calf as well, when the neuropathy is particularly bad and it's impossible to get to sleep.
I hope we get some other helpful ideas too.
Warm regards, Laurie

Has anyone tried Metanx a supplement for neuropathy that is folic acid, B vitamins. Medicare won’t pay as it’s a supplemental. Cheapest I could find was $90 for 90 days. Walgreens was $122. Haven’t received or taken it yet. Wondering if anyone else has?

I just participated in a 4 week research study at Mayo in Rochester to see if CBD cream lessened neuropathy. I used a CBD cream for 2 weeks and a placebo cream for 2 weeks. Did not know which cream I had which 2 weeks until the end of the study. Happy to say the CBD cream did work for me! Directions were to apply it morning and evening. Now that I have ordered some I find I can apply it once a day and it helps.

Most days neuropathy in hands is so that I can now feel to button clothes and put on jewelry. The tingling in my feet is also lessened. I think sometime arthritis gets in the way.

The cream that was used in the study and that I ordered is CBD Relief Cream from https://nightingale-remedies.com/cbd_cream.php

Data is still being collected so results of research study have not been published. We all react differently to different treatments but just wanted to share this part of my journey.

Mugs, I think you meant to post the link to the website, not the contact email. I modified your post so that it links to the website where people can read more info.

How interesting to have been a part of the study, @mugs24cancer. Do you know if the study has been published?

Study has not been published. Still looking for more participants. Dr. Charles Loprinzi is the doctor at Mayo conducting the study. Requirement to participate in study is that the neuropathy is the result of chemotherapy and that you are a Mayo patient.

Oh, I found it here:
- Topical Cannabidiol for the Treatment of Chemotherapy-Induced Peripheral Neuropathy https://clinicaltrials.gov/ct2/show/NCT05388058

Thanks for outlining the criteria for participation. I hope there are other Mayo patients who can take advantage of participating in the study.

I see that Dr. Loprinzi has done and is doing a lot of research on chemo-induced neuropathy. That's great to see.

Welcome @emilyandersontarr. So many members talk about their neuropathy starting or being at its worst in the evening or during the night. I moved your post to this existing discussion:
- Neuropathy Pain at Night: What helps?: https://connect.mayoclinic.org/discussion/night-pain-2/

I did this so you can read past posts and easily connect with other members, like @artist01 @bonniethompson1234 and more.

@johnbishop . Hi John. I also sleep in my recliner every night, and have done so for four years due to a brainstem AVM and vertigo. I find that lying flat in a bed makes my vertigo much worse, somewhat the same feeling as having a wee bit too much vino,
'way back in the good old days.
My Lay-Z-Boy chair is my best friend these days! Warmest wishes,
Laurie

Thank you.