Is restless leg (RLS) related to serotonin syndrome? Tips for relief?

@rockrod Welcome to connect we aren't Dr,s but may be able to help with what tools we have .RLS had it and don't anymore These are suggestions that work make sure you drink enough water very important , potassium and magnesium are important minerals are you on any supplements if you don't get these from food you should have a blood test for your mineral count. A old remedy is pickle juice drink when it starts. I wish you all the best

@rockrod, good questions. You'll notice that I modified the title of your discussion to reflect the questions you wished to ask members and to distinguish it from the other discussions about Restless Leg Syndrome (RLS). You may find these useful to read through for tips on how to get relief
- Restless Leg Syndrome: https://connect.mayoclinic.org/discussion/restless-leg-syndrome-2a74e5/
- Peripheral neuropathy, RLS and PLMD: https://connect.mayoclinic.org/discussion/periodic-limb-movement-disorder/
- restless legs syndrome (RLS) and mirtazapine: https://connect.mayoclinic.org/discussion/rls-and-antidepressants/:

Medicines that increase serotonin bioavailability (antidepressants) have been associated with increased risk or aggravation of RLS. Fellow members like @rwlovell @davidlyle7 and @kdo0827 might be able to add some thoughts here.

Rod, have you had a recent change in medications?

RLS is a product of dopamine dysfunction, NOT serotonin. I used to take Pramipexole, now I take Lyrica 200 mg. Works just fine.

Thanks for the tips, I’ll give them a try.

Thanks for your interest. I am on quite a lot of medication including Mirtazapine, Tramadol and Fentanyl patches. I’ve read that a combination of any two of these medications, depending on dosage can lead to Seratonin Syndrome. From what I can gather symptoms can be very similar to RLS.

Somewhere I read that using a hot pad would help at night. It works. I have also found a product from magnalife called relaxing leg cream, it works well too

Hi @lioness, what are your recommendations for potassium and magnesium for a 90 year old suffering from RLS. HTN and DMII are also dxs. Thanks for your insight!

@avmcbellar Thanks for asking me my recommendations. This is all I can address as I don't know what those other,s are . Since your already taking Potassium and Magnesium which I take at dinner ,drink plenty of water . Sometimes some leg exercises help and of course Dill pickle juice when the RLS start . It has to be the Dill juice not sweet . Its an old remedy but works . You must be asking this for your Mom ? your picture isn,t of a 90 year old I had to upgrade my email address so just catching up with questions sorry to be late in answering.

@lioness I appreciate you getting back to me. The other diagnoses are hypertension and diabetes. I know pickles are high in salt. My mother can try pickle juice. Drinking lots of water would help dilute the salt content. Thanks for the suggestion. No worries with answering emails. They can can get overwhelming at times. I didn’t feel your response was late at all. Like I said you get to it when you can.

@avmcbellar I get about 100 emails everyday and if I don't answer right away I forget about them bad habit I have Diet is so important to follow with diabetes That's the first thing If she is on Metformin take it according to Dr,s order ,some light exercise but following a diabetic diet is #1 Does she take B P pills for her hypertension See Dr for both as I do for certain conditions