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@rwlovell

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Joined: Jun 30, 2017

restless legs syndrome (RLS) and mirtazapine

Posted by @rwlovell, Jun 30, 2017

Hi,
I recently started mirtazapine and have had a good initial reaction to the drug – my energy is better, my mood. The one rather major problem is it seems to trigger or exacerbate my RLS. I had been on tramadol (for back pain) about a week before starting mirtazapine and I have read that they can interfere with each other and cause RLS. My question is should I look for another antidepressant or is it possible that this will improve with time. Right now I am awake all night until about 5 AM when I catch a few hours of sleep. It is pretty rough.

REPLY

Hello @rwlovell and welcome to Mayo Connect. I see that you are experiencing side effects of a medicine you have taken. I’m sure this must be difficult as it is interfering with your sleep. Perhaps some of our members will relate to this experience and respond to your situation. In the meantime, I was wondering if you have you talked with your doctor regarding this side effect and if he/she feels that this will be temporary or not? Teresa

@hopeful33250

Hello @rwlovell and welcome to Mayo Connect. I see that you are experiencing side effects of a medicine you have taken. I’m sure this must be difficult as it is interfering with your sleep. Perhaps some of our members will relate to this experience and respond to your situation. In the meantime, I was wondering if you have you talked with your doctor regarding this side effect and if he/she feels that this will be temporary or not? Teresa

Jump to this post

Thanks for replying! We have talked to the doctor on the phone, but the only advice at this point is: stop taking the new drug for now and go back to your former protocol. I did that last night. Still had the RLS, but maybe not as bad. Still kept me awake until about 4:30 AM. Ugh. I have an appointment on Monday. In the meantime….two more nights to go until then and now without the stronger antidepressant — back to citalaphram.

@rwlovell I can understand your continued frustration in not sleeping well, but I am so glad to hear that you talked with your doctor and that you have an appointment on Monday. If the RLS is a bit improved, perhaps you will notice more improvement each night? Let’s hope so. Let us continue to know how we can support you. Teresa

Hello @rwlovell,

I’d like to add my welcome, and thank you for joining us on Connect, and sharing your symptoms.

In “Anyone here dealing with peripheral neuropathy?” http://mayocl.in/2aWCYXq, @emilyanne @gailfaith @ridgerunner @peggyj4411 @rabbit10 discuss restless leg syndrome (RLS), and I hope they, along with @pattitoo @wljs @lknightb @ptfitzy, will join in with some insight for you.

You may also wish to view this discussion in the Sleep Health group:
Restless Health Syndrome http://mayocl.in/2td1w69

@brit @lesbatts @painwarrior @lakelifelady @roxie43 have posted about Mirtazapine (Remeron), and I wonder if they have any suggestions?

RLS is unpredictable in my case. Naturally as long as I am on my feet no problem of course.
However soon has I sit down, seems it is when I am just getting comfortable, like in a
recliner or lay down it can start in, only one leg at time. If I get up and walk a bit it seems
to dissipate on occasion. A few years ago I did plenty of reading on RLS and my GP would NOT give me
what I read often will work, Diazapam — a Neurologist agreed it was helpful and it works
for me. I ONLY take it if I am having an episode. I don’t feel my case is severe in frequency, as all of us know, we can’t sleep with it.
Best wishes to all.

@kanaazpereira

Hello @rwlovell,

I’d like to add my welcome, and thank you for joining us on Connect, and sharing your symptoms.

In “Anyone here dealing with peripheral neuropathy?” http://mayocl.in/2aWCYXq, @emilyanne @gailfaith @ridgerunner @peggyj4411 @rabbit10 discuss restless leg syndrome (RLS), and I hope they, along with @pattitoo @wljs @lknightb @ptfitzy, will join in with some insight for you.

You may also wish to view this discussion in the Sleep Health group:
Restless Health Syndrome http://mayocl.in/2td1w69

@brit @lesbatts @painwarrior @lakelifelady @roxie43 have posted about Mirtazapine (Remeron), and I wonder if they have any suggestions?

Jump to this post

Mirtazapine did not affect (RLS). It just didn’t seem to give me the relief with my anxiety and depression That’s when my doctor changed me to one 40mg Paxil a day and a half of diazapam in the a.m. and half in the p.m. It has helped some but still get my days of depression and anxiety. Any suggestions out there?
God Bless Patti

I’ve been on Mirtazapine for a little over a year now and haven’t noticed a problem with my RLS. However, I am on a Fentanyl patch for my back and leg pain, and I’ve noticed if I forget to change my patch my RLS acts up. When it does, I take Requip which seems to work well for me. Whenever I try to come off my patch or lower the dosage, my RLS really acts up. Although my RLS isn’t in my legs, it used to be but has now moved into my arms. It is so frustrating. If you need the Tramadol regularly, maybe you could talk to your doctor about switching to a Fentanyl patch.

@kanaazpereira

Hello @rwlovell,

I’d like to add my welcome, and thank you for joining us on Connect, and sharing your symptoms.

In “Anyone here dealing with peripheral neuropathy?” http://mayocl.in/2aWCYXq, @emilyanne @gailfaith @ridgerunner @peggyj4411 @rabbit10 discuss restless leg syndrome (RLS), and I hope they, along with @pattitoo @wljs @lknightb @ptfitzy, will join in with some insight for you.

You may also wish to view this discussion in the Sleep Health group:
Restless Health Syndrome http://mayocl.in/2td1w69

@brit @lesbatts @painwarrior @lakelifelady @roxie43 have posted about Mirtazapine (Remeron), and I wonder if they have any suggestions?

Jump to this post

Make sure you get exercise, especially walking later in the day to help with RLS while taking Remeron. Also, take it around 8 pm so that you might be moving around some before bed. If it starts standing on the affected leg or stretching it out and kicking from side of bed helps too.

@kanaazpereira

Hello @rwlovell,

I’d like to add my welcome, and thank you for joining us on Connect, and sharing your symptoms.

In “Anyone here dealing with peripheral neuropathy?” http://mayocl.in/2aWCYXq, @emilyanne @gailfaith @ridgerunner @peggyj4411 @rabbit10 discuss restless leg syndrome (RLS), and I hope they, along with @pattitoo @wljs @lknightb @ptfitzy, will join in with some insight for you.

You may also wish to view this discussion in the Sleep Health group:
Restless Health Syndrome http://mayocl.in/2td1w69

@brit @lesbatts @painwarrior @lakelifelady @roxie43 have posted about Mirtazapine (Remeron), and I wonder if they have any suggestions?

Jump to this post

Requip works.

Liked by barbarn

@hopeful33250

Hello @rwlovell and welcome to Mayo Connect. I see that you are experiencing side effects of a medicine you have taken. I’m sure this must be difficult as it is interfering with your sleep. Perhaps some of our members will relate to this experience and respond to your situation. In the meantime, I was wondering if you have you talked with your doctor regarding this side effect and if he/she feels that this will be temporary or not? Teresa

Jump to this post

Hello @rwlovell I’ve been thinking about you. As I recall you had a doctor’s appointment scheduled for Monday. I hope that all went well. Are you sleeping any better now? Teresa

@pattitoo

RLS is unpredictable in my case. Naturally as long as I am on my feet no problem of course.
However soon has I sit down, seems it is when I am just getting comfortable, like in a
recliner or lay down it can start in, only one leg at time. If I get up and walk a bit it seems
to dissipate on occasion. A few years ago I did plenty of reading on RLS and my GP would NOT give me
what I read often will work, Diazapam — a Neurologist agreed it was helpful and it works
for me. I ONLY take it if I am having an episode. I don’t feel my case is severe in frequency, as all of us know, we can’t sleep with it.
Best wishes to all.

Jump to this post

@pattitoo, I have to say meds work differently on different persons. What I find works well for my very aggrevated case of RLS is a simple thing. You can find it in your nearest pharmacy for a minimal fee. It is called restful leg. My son saw how much I suffered and he told me that it worked for him before, and I told him that I would try it. I have to admit I was skeptical at first, but I put 3 of them under my tongue, and within 15 minutes, I was fine. I have been using them now for over 5 years. Every time I start an episode of RLS, I head for my purse to get 2 to 3 tablets from the small tube they come in, and I place them under my tongue, and they melt quickly, and before you know it, I am back sitting on my couch enjoying the movie I just could not sit and watch 15 minutes before, without jumping up like a crazy person, and stretching my legs all over the place and apologizing to anyone who was in the room for interrupting them, with my dancing around like a clown.

Liked by barbarn, wba3721

@smileyface55

@pattitoo, I have to say meds work differently on different persons. What I find works well for my very aggrevated case of RLS is a simple thing. You can find it in your nearest pharmacy for a minimal fee. It is called restful leg. My son saw how much I suffered and he told me that it worked for him before, and I told him that I would try it. I have to admit I was skeptical at first, but I put 3 of them under my tongue, and within 15 minutes, I was fine. I have been using them now for over 5 years. Every time I start an episode of RLS, I head for my purse to get 2 to 3 tablets from the small tube they come in, and I place them under my tongue, and they melt quickly, and before you know it, I am back sitting on my couch enjoying the movie I just could not sit and watch 15 minutes before, without jumping up like a crazy person, and stretching my legs all over the place and apologizing to anyone who was in the room for interrupting them, with my dancing around like a clown.

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@smileyface55 – even my small town grocery stocks 'Restful Legs" – I've used it for years. But there are times when I need a little more help. I have used 'Requip" for a long while, but last time I called for a renewal of that my dr changed my prescription to "Mirapex" and … I went 10 days with NO leg movement!!!!! It has started again – I guess we all just have to figure out a regimen that works. Hoping your dr. is willing to work with you too!!!

Holy smokes?! I just signed up and I couldnt beleive your post!! I have had crps for 10 yrs in all 4 limbs now. A pain speciaoist decided to try this drug. It has been 2 wks now since I stopped. I was on 25mg 2x a day. I have never been through such a living nightmare. The rls led to the worse muscle spasms and dystopia I have ever had. I broke out in blisters. As a matter of fact the one on my thumb got so bad it ate right to the bone!! I became suicidal etc.. Im not a drama quenn either and dont belong on any other crps group. Im just saying. PLEASE DR GOOGLE THE SIDE EFFECTS… Please. Yes I felt happy too and actually lost 5 lbs. 👍lol

@124811

Holy smokes?! I just signed up and I couldnt beleive your post!! I have had crps for 10 yrs in all 4 limbs now. A pain speciaoist decided to try this drug. It has been 2 wks now since I stopped. I was on 25mg 2x a day. I have never been through such a living nightmare. The rls led to the worse muscle spasms and dystopia I have ever had. I broke out in blisters. As a matter of fact the one on my thumb got so bad it ate right to the bone!! I became suicidal etc.. Im not a drama quenn either and dont belong on any other crps group. Im just saying. PLEASE DR GOOGLE THE SIDE EFFECTS… Please. Yes I felt happy too and actually lost 5 lbs. 👍lol

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HI, @124811 – welcome to Mayo Clinic Connect. Sounds like you had a really tough time on the medication.

Just wanted to clarify: the medication prescribed by the pain specialist was mirtazapine? If so, was it prescribed for depression, or for a different purpose?

Liked by barbarn

@rwlovell

Thanks for replying! We have talked to the doctor on the phone, but the only advice at this point is: stop taking the new drug for now and go back to your former protocol. I did that last night. Still had the RLS, but maybe not as bad. Still kept me awake until about 4:30 AM. Ugh. I have an appointment on Monday. In the meantime….two more nights to go until then and now without the stronger antidepressant — back to citalaphram.

Jump to this post

In reply to @rwlovell I am new to Mayo Connect so hope I am doing this right. I am on .5 MG of Roprinorol at dinner & 3 MG of Ropriorol at about 8:30p.m. I still have some RLS between dinner & 8:30, but by around 10 p.m. I can't stay awake. Usually sleep until 5 a.m. or so.
Hope that might help you.

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