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Is restless leg (RLS) related to serotonin syndrome? Tips for relief?

Brain & Nervous System | Last Active: Dec 17, 2023 | Replies (56)
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@colleenyoung

@rockrod, good questions. You'll notice that I modified the title of your discussion to reflect the questions you wished to ask members and to distinguish it from the other discussions about Restless Leg Syndrome (RLS). You may find these useful to read through for tips on how to get relief
- Restless Leg Syndrome: https://connect.mayoclinic.org/discussion/restless-leg-syndrome-2a74e5/
- Peripheral neuropathy, RLS and PLMD: https://connect.mayoclinic.org/discussion/periodic-limb-movement-disorder/
- restless legs syndrome (RLS) and mirtazapine: https://connect.mayoclinic.org/discussion/rls-and-antidepressants/:

Medicines that increase serotonin bioavailability (antidepressants) have been associated with increased risk or aggravation of RLS. Fellow members like @rwlovell @davidlyle7 and @kdo0827 might be able to add some thoughts here.

Rod, have you had a recent change in medications?

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Replies to "@rockrod, good questions. You'll notice that I modified the title of your discussion to reflect the..."
rockrod | @rockrod | Sep 7, 2020

Thanks for your interest. I am on quite a lot of medication including Mirtazapine, Tramadol and Fentanyl patches. I’ve read that a combination of any two of these medications, depending on dosage can lead to Seratonin Syndrome. From what I can gather symptoms can be very similar to RLS.

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