What is the best probiotic to take while on triple antibiotic therapy?

Posted by corina3892 @corina3892, Aug 15 6:41pm

I was just diagnosed with pulmonary MAI after a biopsy. I will be on a regimen of Rifampin/Ethambutol/Azithromycin for 12-18 months. I want to avoid a yeast infection(s). My reading states there are two probiotics: Saccharomyces boulardii and lactobacillus rhamnosus GG. I am leaning toward the Saccharomyces bollardii as it cannot be destroyed by the triple antibiotic. I do not see the pulmonologist until the end of the month, but I want to be prepared with questions. Suggestions?

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Profile picture for suzieq11 @suzieq11

@kayelynn My first treatment for MAC failed in 2021. Symptoms recurred within a few months. My pulmonologist retired telling me "no follow up needed". I waited 3 years to find a new pulmonologist. I am now allergic to most antibiotics so not a good candidate for tx ( I am 81). I have developed bronchiectasis with shortness of breath and night sweats) Now I have a good pulmonologist and a terrific ID doctor - they are monitoring CT scans and have added nebulizing tx with saline and levalbuteral to Previously ignored airway clearance advice. I admit to ignoring routine medical issues for six years due to caregiving for husband who recently died from Parkinsons Disease. Now I am paying attention to nutrition, exercise and airway clearance and frightened of getting a secondary lung infection. This is a cautionary tale for you caregivers out there - you must take care of your health - find a way to do it. Long term caregiving is a risk factor for exacerbation of chronic disease in the elderly. Best wishes to all - your advice has helped me.

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@suzieq11 Do you have a flutter valve?. my Lung doctor gave me a prescription for one when you blow on it. It kind of vibrates. That’s supposedly helps to keep your. Airways clear.

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My husband, a nutritional consultant, recommended saccharomyces boulardii to me since it survives antibiotics. I only take antibiotics 3 days a week, so it take probiotics on the “off” days and saccharomyces every day. Here’s an article describing why it is still beneficial to take probiotics even when on antibiotic treatment. I realize not everyone agrees, but I’m going for it because I want a reasonably healthy gut when this is over. https://www.mygenefood.com/blog/saccharomyces-boulardii-antibiotic-resistant-probiotic/

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Does anyone on here take the MAC meds Monday thru Friday? I plan to start the drugs next week and I’ve noticed comments on here seem to take either 3 times a week or every day. I’ve actually read that Monday-Friday is very unusual.

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Profile picture for jessmac @jessmac

Does anyone on here take the MAC meds Monday thru Friday? I plan to start the drugs next week and I’ve noticed comments on here seem to take either 3 times a week or every day. I’ve actually read that Monday-Friday is very unusual.

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@jessmac You are right, that is quite unusual. Did the doctor explain the reason for this departure from normal protocol? Are you seeing a pulmonologist and/or infectious disease doc who specializes in treating MAC?

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Profile picture for Sue, Volunteer Mentor @sueinmn

@jessmac You are right, that is quite unusual. Did the doctor explain the reason for this departure from normal protocol? Are you seeing a pulmonologist and/or infectious disease doc who specializes in treating MAC?

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@sueinmn I’m seeing a pulmonologist, have been going to him for a few years for COPD and bronchitis bouts. The current infection appeared on a CT scan earlier this year when he gave the option of a biopsy or trying one last round of antibiotics- I chose the latter. That didn’t work so I had the biopsy in June and didn’t get the results until early August. When he told me I had MAC and requiring all these antibiotics for the next year I was so shocked didn’t really pay much attention to the M-F routine. He just commented that the schedule would give my body a break for recovery each week. I just stumbled over discrepancy from the norm thru AI and this group. I do plan to send him a note questioning the proposed treatment. Thanks for your interest - only comment so far.

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Profile picture for jessmac @jessmac

@sueinmn I’m seeing a pulmonologist, have been going to him for a few years for COPD and bronchitis bouts. The current infection appeared on a CT scan earlier this year when he gave the option of a biopsy or trying one last round of antibiotics- I chose the latter. That didn’t work so I had the biopsy in June and didn’t get the results until early August. When he told me I had MAC and requiring all these antibiotics for the next year I was so shocked didn’t really pay much attention to the M-F routine. He just commented that the schedule would give my body a break for recovery each week. I just stumbled over discrepancy from the norm thru AI and this group. I do plan to send him a note questioning the proposed treatment. Thanks for your interest - only comment so far.

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@jessmac I’m assuming 3 times a week is for a maybe minor infection (if there’s such a thing) and every day would be for more serious problem. Maybe he figures I’m in between minor and serious so opted for the middle of the two time frames??

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Profile picture for jessmac @jessmac

@sueinmn I’m seeing a pulmonologist, have been going to him for a few years for COPD and bronchitis bouts. The current infection appeared on a CT scan earlier this year when he gave the option of a biopsy or trying one last round of antibiotics- I chose the latter. That didn’t work so I had the biopsy in June and didn’t get the results until early August. When he told me I had MAC and requiring all these antibiotics for the next year I was so shocked didn’t really pay much attention to the M-F routine. He just commented that the schedule would give my body a break for recovery each week. I just stumbled over discrepancy from the norm thru AI and this group. I do plan to send him a note questioning the proposed treatment. Thanks for your interest - only comment so far.

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@jessmac I am not a professional and have only been at all this with my having been diagnosed with Bronchiectasis and my MAC infection since 2023.
However something sounds amiss for several reasons. One being your having to wait until August from June to get the results and as Sue said above about the med schedule.
Are you seeing someone who is in a Center of Excellence health system.?
So many individuals have needed pulmonologists that concentrate more on people with Bronchiectasis rather than be a generalist pulmonologist. Too many pulmonologists are out there on there own without studying the most recent information about the diseases they are suppose to be helping with. They often are not up to snuff with all lung protocols. This happened to me after seeing my generalist pulmonologist the third time. I realized he was not up to snuff and I immediately made an appointment with National Jewish Hospital.
Sorry to give you all this to think about, but it is your health and we need experts with having this lung problem.
Barbara

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Profile picture for jessmac @jessmac

Does anyone on here take the MAC meds Monday thru Friday? I plan to start the drugs next week and I’ve noticed comments on here seem to take either 3 times a week or every day. I’ve actually read that Monday-Friday is very unusual.

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@jessmac I took the big 3 for 2 years and my routine was 3days a week. Your 5days sounds brutal. Go to NJH

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Per the IDSA guidelines—In patients with cavitary or severe/advanced nondular bronchiectatic macrolide-susceptible MAC pulmonary disease we suggest a daily macrolide-based regimen rather than three times per week macrolide-based regimen.

All the best,
Linda Esposito

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