Reclast infusion side effects?

Posted by ladybugnc @ladybugnc, May 26, 2025

I had the Reclast infusion 5 months ago in my left arm. I have started having pain in that arm now, with loss of strength. Has this happened to anyone else?

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Profile picture for tiza @tiza

@dannyandebbie
Im sorry you’re having to deal with these continuing discomfort.
Same here, after 1 year+ I’m still struggling with pain on my rib cage and stomach.
This drug should be banned and we compensated for the trauma and troubles.

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@tiza it’s odd you mention rib cage; All day yesterday and today I’ve had great discomfort from my back to my stomach, felt I was coming down with something, guess now I know. It is awful what this medication has done to some and great for others!

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Profile picture for carole59 @carole59

@dannyandebbie
That definitely is discouraging and I am so sorry you continue to deal with those side effects after all this time, although I guess it's comforting to know this is not all in my head. I am with you 100% on Never Again! I am going to try to get a referral to a pain management specialist. I initially had so much pain in my hip I thought my hip replacement had failed, but imaging showed it was fine. The most upsetting thing is that I did this to myself. I had terrible DEXA numbers, but I felt good and I think my active lifestyle was the reason that despite those terrible numbers, I never had a fracture. But the endocronologist insisted I needed to do something and painted such a bleak picture of my future that I agreed. Now I'm so weak and in so much pain I can't do much of anything, which obviously is not helpful. Complete and total insanity!

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@carole59 exactly what happened to me!

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Profile picture for osteopatient2026 @osteopatient2026

@dannyandebbie
What drug(s) did you start with before Reclast/Prolia …Forteo…Tymlos?
If you never had this pain before why are the doctors denying that it’s ?
What improvements if any did you have?

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@osteopatient2026 They offered nothing prior to the Reclast infusion and I have seen zero improvement from what I know until I have a blood test in September. The sad part is only my legs and lower back bothered me prior from Ankolosing spondylitis. Now it shoulders, arms, rib cage, both hips and groin area; pain wise. Then there is blurred vision, nausea feeling and cramps that wake me in the middle of the night! And they insist I receive another infusion, NOT! This medication should be pulled from the market and patients that endured negative results compensated for both current and future ( Unexplained, according to both Rheumatologist and / or Neurologist) symptoms.

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Profile picture for carole59 @carole59

@dannyandebbie
That definitely is discouraging and I am so sorry you continue to deal with those side effects after all this time, although I guess it's comforting to know this is not all in my head. I am with you 100% on Never Again! I am going to try to get a referral to a pain management specialist. I initially had so much pain in my hip I thought my hip replacement had failed, but imaging showed it was fine. The most upsetting thing is that I did this to myself. I had terrible DEXA numbers, but I felt good and I think my active lifestyle was the reason that despite those terrible numbers, I never had a fracture. But the endocronologist insisted I needed to do something and painted such a bleak picture of my future that I agreed. Now I'm so weak and in so much pain I can't do much of anything, which obviously is not helpful. Complete and total insanity!

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@carole59 best of luck with the pain clinic! Hopefully our body over powers the poison we allowed into our bodies. It just goes to show how valuable we are to others suggestions!

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Profile picture for dannyandebbie @dannyandebbie

@carole59 not to sound discouraging but it has been a little over two years for me and still have symptoms. Started in my shoulders and left foot; they continue to feel extremely lame and weak. Then it went into my hips, groin and vision areas. I am 69 years old and had none of these symptoms before the damn infusion; retirement was going to be fun they say. Well, I was talked into this infusion but Never again. I go in September to review my new scores, not sure why because I’ll never have another infusion. Dr says my symptoms are not from the infusion yet Rheumatology and neurologist find no reason for the on going discomfort. My personal opinion is that the FDA should band this medication unless it is shared All the potential side effects before administration of the medication. Once one receives the medication there are no quick ways ( no treatment that I’ve read) to reverse the side effects .

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@dannyandebbie Me too!!!!!!

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Profile picture for osteopatient2026 @osteopatient2026

@dannyandebbie
What drug(s) did you start with before Reclast/Prolia …Forteo…Tymlos?
If you never had this pain before why are the doctors denying that it’s ?
What improvements if any did you have?

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@osteopatient2026 is oral Fosamax an option?

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Profile picture for tiza @tiza

Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

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Reading through all of these posts describing your side effects from Reclast is frightening. I feel for each and every one of you. I am on the cusp trying to decide whether or not to try Reclast. Fosomax gave me miserable nausea and vomiting. I am a 78 year old small boned female and I have had osteopenia for a long time and only recently moved into the actual osteoporosis diagnosis in my femoral heads. I have already had 4 fractures not caused by osteoporosis. I have CRPS, a chronic pain disorder which makes the choice for an osteoporosis drug very limited. My endo has chosen Reclast and Prolia as a second choice. He sent me to a second endo who specializes in osteoporosis and bone density disorders. They are both recommending Reclast. I am going to talk to my pain management specialist about the Reclast but I am very strongly leaning towards saying no. This is a really hard choice for me as I have a number of other comorbidities making exercise a poor option. I am limited to walking which I am already doing. It seems that I have to make a decision about whether to take a chance on a medication that could make my pain problems worse or take my chances on more fractures. I don't know how to decide. What are those of you who have decided against any more Reclast infusions doing? Have you tried any different drugs or are you simply hoping for the best? Getting old shouldn't be this hard!

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Profile picture for dannyandebbie @dannyandebbie

@osteopatient2026 They offered nothing prior to the Reclast infusion and I have seen zero improvement from what I know until I have a blood test in September. The sad part is only my legs and lower back bothered me prior from Ankolosing spondylitis. Now it shoulders, arms, rib cage, both hips and groin area; pain wise. Then there is blurred vision, nausea feeling and cramps that wake me in the middle of the night! And they insist I receive another infusion, NOT! This medication should be pulled from the market and patients that endured negative results compensated for both current and future ( Unexplained, according to both Rheumatologist and / or Neurologist) symptoms.

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@dannyandebbie Hello, I am so sorry that has happened to you. I find that some doctors deny things because they are afraid of being sued. It stinks!

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Profile picture for tiza @tiza

Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

Jump to this post

I had a horrible first infusion. But I am going back next year. They will do it entirely different. (don't know why they didn't do that from the start!!!) But I read the research and a VERY SMALL amount have reaction (like 1%?) and a one-hundredth of that percent have problems at the second infusion. My take on it is that the medicine causes a reaction in the places in your body that need help. I had the WORST reaction in my cervical spine and it turned out my bones were "mush". So I think the medicine goes where it needs to and that you just don't know that you really needed it there. I'm having positive results, and I'm going to stick with it even with the hardships because I NEED to have stronger bones. I went into menopause early, and it really caused havoc with my bone density. I go to UCSD for infusions and they are caring about making my next infusion better so they will slow it down and give less medicine. They have found that the dose can be lowered without compromising the result. Yes, it was the singularly most awful experience I've had but I'm not giving up.

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Profile picture for loriesco @loriesco

I had a horrible first infusion. But I am going back next year. They will do it entirely different. (don't know why they didn't do that from the start!!!) But I read the research and a VERY SMALL amount have reaction (like 1%?) and a one-hundredth of that percent have problems at the second infusion. My take on it is that the medicine causes a reaction in the places in your body that need help. I had the WORST reaction in my cervical spine and it turned out my bones were "mush". So I think the medicine goes where it needs to and that you just don't know that you really needed it there. I'm having positive results, and I'm going to stick with it even with the hardships because I NEED to have stronger bones. I went into menopause early, and it really caused havoc with my bone density. I go to UCSD for infusions and they are caring about making my next infusion better so they will slow it down and give less medicine. They have found that the dose can be lowered without compromising the result. Yes, it was the singularly most awful experience I've had but I'm not giving up.

Jump to this post

@loriesco
Have you had any updates on your T Scores and bone markers, pinp, CTX, calcium, D

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