ExoDx test: What scores are worrisome?

Posted by ginger38314 @ginger38314, Jun 18 1:12am

Recently I had an mri for an psa of 5, they found an .8 cm wedge lesion and said fi di gs consistent with prostatitis and gave it a pirads 4 rating. He wanted to do a exodx test to determine whether to proceed to a biopsy. What scores are worrisome and how accurate are they in predicting aggressive cancers. Say if you get a 30 score does that mean higher probability of higher Gleason score than 7.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for ginger38314 @ginger38314

Re recently mri a .8cm lesion wedge shaped and linear rated pirads 4 t2 with a dwi of 3, and findings noted consistent with prostate Infection ut my exods score came in at 77 which was very concerning biopsy scheduled for July 6th any thoughts?

Jump to this post

With your PSA bouncing erratically, although no overly high, i was in a similar position. My PSA went from it’s annual stability of years of 1.9 as follows over the next three years:
3.0, 2.5, 2.3, 3.2, 4.0, 2.9, 3.4, 4.1, 3.0, 3.3. Initially i was told my PSA was consistent with my age until I went back gathering all the data and talked them into the MRI. My initial MRI labeled my findings suggestive if subacute on chronic prostatitis, so we just continued the PSA testing quarterly. Also initially with those first couple drops took the anxiety away. Just getting really concerned again hitting 4., but dropped again. It was my primary doctor not my urologist who knew what was happening and my concern, told me his father was in a similar situation regarding getting a biopsy and they obtained the ExoDx test., so he was the one that actually ordered it for me and it came back 72.56. This then got me another MRI 18 months after my first one with the PIRADS 4 lesion, although that specific lesion benign found cancer elsewhere from my biopsy and as they say the rest is history. I think moving forward with your biopsy is good on July 6th and just enjoy July 4th!

REPLY
Profile picture for ginger38314 @ginger38314

Re recently mri a .8cm lesion wedge shaped and linear rated pirads 4 t2 with a dwi of 3, and findings noted consistent with prostate Infection ut my exods score came in at 77 which was very concerning biopsy scheduled for July 6th any thoughts?

Jump to this post

I think a biopsy is definitely a good next step. The ExoDx test is not one of the most accurate any more as the technology has advanced, but it can give a good indication of the presence of cancer.

I had an ExoDx test and the results were elevated (I think the score was 35) which led to an MRI which was completely clear and then a saturation biopsy. The saturation biopsy showed two cores that had a small amount of cancer that was graded as 4+5, and led to a RALP six weeks later. The final pathology report after the RALP downgraded my final Gleason score to 4+3 with tertiary amount of 5.

I would not have been diagnosed as quickly as I was without the ExoDx test so I am a big believer in these newer tests that are more definitive than the PSA test. It's good that you had the test, and given the results I agree that a biopsy is a good next step. I would suggest the saturation biopsy (typically 24 cores) to make sure that all parts of the prostate gland are sampled.

REPLY
Profile picture for ginger38314 @ginger38314

Re recently mri a .8cm lesion wedge shaped and linear rated pirads 4 t2 with a dwi of 3, and findings noted consistent with prostate Infection ut my exods score came in at 77 which was very concerning biopsy scheduled for July 6th any thoughts?

Jump to this post

While the information you have sounds negative. There’s really no way of knowing anything until you get a biopsy.

PIRADS 4 Doesn’t definitely mean you have prostate cancer or that it’s aggressive. The ExoDx Score is high, But you don’t know what your biopsy shows yet so it’s really not possible to guess what’s going on. A high score does not automatically guarantee that cancer is present, but it strongly suggests that further investigation is warranted

A 77 could mean you have a chance of a Gleason seven or higher, not that you have something that’s not treatable. You could live for decades. You just need more information.

Definitely not time to panic since prostate cancer is a chronic disease for almost all of us these days.

REPLY
Profile picture for wheel1 @wheel1

With your PSA bouncing erratically, although no overly high, i was in a similar position. My PSA went from it’s annual stability of years of 1.9 as follows over the next three years:
3.0, 2.5, 2.3, 3.2, 4.0, 2.9, 3.4, 4.1, 3.0, 3.3. Initially i was told my PSA was consistent with my age until I went back gathering all the data and talked them into the MRI. My initial MRI labeled my findings suggestive if subacute on chronic prostatitis, so we just continued the PSA testing quarterly. Also initially with those first couple drops took the anxiety away. Just getting really concerned again hitting 4., but dropped again. It was my primary doctor not my urologist who knew what was happening and my concern, told me his father was in a similar situation regarding getting a biopsy and they obtained the ExoDx test., so he was the one that actually ordered it for me and it came back 72.56. This then got me another MRI 18 months after my first one with the PIRADS 4 lesion, although that specific lesion benign found cancer elsewhere from my biopsy and as they say the rest is history. I think moving forward with your biopsy is good on July 6th and just enjoy July 4th!

Jump to this post

I will let you know as soon as I find out the results.

REPLY
Profile picture for Jeff Marchi @jeffmarc

While the information you have sounds negative. There’s really no way of knowing anything until you get a biopsy.

PIRADS 4 Doesn’t definitely mean you have prostate cancer or that it’s aggressive. The ExoDx Score is high, But you don’t know what your biopsy shows yet so it’s really not possible to guess what’s going on. A high score does not automatically guarantee that cancer is present, but it strongly suggests that further investigation is warranted

A 77 could mean you have a chance of a Gleason seven or higher, not that you have something that’s not treatable. You could live for decades. You just need more information.

Definitely not time to panic since prostate cancer is a chronic disease for almost all of us these days.

Jump to this post

Well they also noted in the mri findings consistent for prostatitis and the
lesion is wedge shaped and .8cm, but that high nu.ber scares me. Atleast
it's confined t2.

REPLY
Profile picture for rider51 @rider51

I think a biopsy is definitely a good next step. The ExoDx test is not one of the most accurate any more as the technology has advanced, but it can give a good indication of the presence of cancer.

I had an ExoDx test and the results were elevated (I think the score was 35) which led to an MRI which was completely clear and then a saturation biopsy. The saturation biopsy showed two cores that had a small amount of cancer that was graded as 4+5, and led to a RALP six weeks later. The final pathology report after the RALP downgraded my final Gleason score to 4+3 with tertiary amount of 5.

I would not have been diagnosed as quickly as I was without the ExoDx test so I am a big believer in these newer tests that are more definitive than the PSA test. It's good that you had the test, and given the results I agree that a biopsy is a good next step. I would suggest the saturation biopsy (typically 24 cores) to make sure that all parts of the prostate gland are sampled.

Jump to this post

Was yours confined and what was your treatment consist of.

REPLY
Profile picture for ginger38314 @ginger38314

Was yours confined and what was your treatment consist of.

Jump to this post

@ginger38314

Yes - my prostate cancer was confined to the prostate gland. I believe the very early detection via the ExoDx test was helpful in the cancer not having spread outside of the prostate.

Due to the initial Gleason 9 pathology on the biopsy cores, I elected to have surgery. The percentage of the prostate that was found to have cancer involvement was 6-10%.

REPLY
Profile picture for ginger38314 @ginger38314

Re recently mri a .8cm lesion wedge shaped and linear rated pirads 4 t2 with a dwi of 3, and findings noted consistent with prostate Infection ut my exods score came in at 77 which was very concerning biopsy scheduled for July 6th any thoughts?

Jump to this post

What was your initial psa and did you have to go on adt therapy and how are you doing now? Just hoping for a decent Gleason score but I guess if it's contained even if it's higher it can be managed with the right treatment. If given the choice I will probably opt for prostate removal. Thanks for responding.

REPLY
Profile picture for ginger38314 @ginger38314

What was your initial psa and did you have to go on adt therapy and how are you doing now? Just hoping for a decent Gleason score but I guess if it's contained even if it's higher it can be managed with the right treatment. If given the choice I will probably opt for prostate removal. Thanks for responding.

Jump to this post

@ginger38314
My PSA was around 5, but it had been at that level for several years. There was a bit of fluctuation but no rapid increase.

My treatment has consisted of only surgery - I have had no other treatment. I have my PSA checked every 3 months and it has been <0.1 each time it has been checked.

REPLY
Profile picture for ginger38314 @ginger38314

Re recently mri a .8cm lesion wedge shaped and linear rated pirads 4 t2 with a dwi of 3, and findings noted consistent with prostate Infection ut my exods score came in at 77 which was very concerning biopsy scheduled for July 6th any thoughts?

Jump to this post

Hopefully have a good result like you. My mri shows no spread and a very small .8cm lesion with a psa of 5 also, but also noted a prostate infection, that's why they did the exodos test because I had some conflicting findings. I'm glad you are doing well it gives me hope that things will work out. Take care.

REPLY
Please sign in or register to post a reply.