Amnestic Mild Cognitive Impairment (aMCI) Diagnosis

@kjc48 The fact that he is keeping up with his personal things has to be encouraging! 😊

We were told those infusions would be beneficial since he's in the early stages of mild cognitive impairment. My husband wanted to do it, so we are doing it. Someone on this site did post they got good results where their treatment has been reduced down to a year vs. the 18 months. But that might be the Kinsula treatments, not the lequembe. Lequembe.com has some aspiring stories from lequembe users. I'm going to go onto that site and hear their story. I will tell you. According to my husband, the infusion clinic is packed with people - all ages from 65 on up - taking lequembe. Best, Karla
Best, Karla

@labrown He has a very good attitude about this whole thing. Yes, I think that's it good that he's keeping up with his personal things, too. That was a fiasco before the diagnosis. I remember his napsack, out in the hotel driveway in the dark, where he had left it on the ground. I'm surprised it wasn't missing the next day. The TV changer gives him trouble, directions, to and from, even with me navigating, the PC trips him up, and various things on the phone, he keeps asking me to help with, but we're managing. He tells me I'm his care partner.
Best, Karla

Hello and sorry about your wife. If you are close to Mayo Clinic or other hospitals who are known to have excellent mental help professionals, they could help you and her to proceed with the proper oral and written testing and other resources to give you a accurate diagnoses and information. Many blessings for you and your family.

@kjc48 how were the leqeumbe infusions?

@frickfrye Welcome to Mayo Clinic Connect! Glad to have you aboard! MCC is a place to share personal experiences. We’re not doctors so no sharing of medicines, except to say they worked or didn’t work. Personal experiences are the most helpful!
@frickfrye What autoimmune disease might you have questions about?

@birdiesville Welcome to Mayo Clinic Connect, a safe place where everyone shares their experiences with autoimmune diseases, medications to treat the disease, and problems concerning AD. We’re not doctors so we don’t diagnose or treat, just saying what works for us or doesn’t .

@birdiesville I answered in the thread above that my husband is now on his 19th lequembe infusion. You ask "how were the lequembe infusions.", they seem to be going well, he hasn't had any side effects. He goes every two weeks, and then a nurse follows up in the GUIDE program to check on him or to see if he needs any level of care. This program is tied to the infusion center my husband goes to in South Florida. I was reluctant initially over these infusions, but for my husband, as I stated in one of the other Connect threads, he has a good attitude and feels in the early mild stages of his MCI, he needed to do something, than sitting back and doing nothing at all. He also takes a supplement called Cerefolin for Brain health, from a company in Tampa (can also get the product now on Amazon), recommended by the same neurologist who is having his office give him the infusions. Hope this helps. Karla

@holycow21 @birdiesville I am so sorry to read that you are struggling with what to do next for your spouse. I would encourage you to see a neurologist if you haven't done that yet, who can determine the cause of her issues. You mentioned she has seen a doctor but I wasn't sure if it was your primary care or someone in neuroscience. My husband was diagnosed with mild Alzheimer's disease in December of 2024, but his issues began in 2021. I understand how scary and overwhelming it is for you and your spouse. My husband started the twice-monthly infusion of the drug Lecanemab (Leqembi) in March 2025. The good news is that the drug is doing what it's supposed to do by reducing the amyloid in the brain. This was confirmed in March 2026 with a PetScan. Just to be clear, he will not regain any memory that he has lost, but it will hopefully slow the progression of the disease. Hope this helps and feel free to reach out and let everyone know how things are going.

@frickfrye Appreciate your comment (also others that have previously). We do live close enough to Mayo in Phoenix - my biggest challenge is convincing my wife that we need to do this. She remains convinced that “she is fine” since all of the testing orchestrated by her primary doctor in TX, involving neurologists, endocrinologists and other specialists did not provide any definitive diagnosis. Trying now to work through her new primary in AZ to influence her to try again, but that doctor will not consult with me without her present (that could get ugly); so running out of options. Does Mayo provide any consultation services to caregivers? Any other suggestions? Thanks again to everyone.

Brian