Smoldering Multiple Myeloma SMM Bloodwork numbers

Posted by DMD81 @dmdinapoli81, Apr 11 10:01am

I am interested in what everyone's numbers were at time of diagnosis of Smoldering Multiple Myeloma SMM? Were you Kappa or Lamba?
kappa free light chain in(mg/L):,
K/L Ratio(mg/L,):,
M-Spike(g/dL):

If Lambda
Free Lambda Lt Chains,S (mg/L):

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amberl99 | @amberl99 | Apr 28 8:40am

In reply to @tdlee64 "I was recently diagnose with MGUS my M protein is 0.13 I'm scared and trying to..." + (show)

@tdlee64 hopefully I can reassure you. This is a low Mspike. Don’t give away your happiness to something you cannot control. Stress will make you sick so refuse it. Just keep exercising, eating nutritiously, train and strengthen your mind, get your labs drawn as they ask, and enjoy your full and healthy life. This is a drop in the bucket.

sallik74 | @sallik74 | Apr 28 3:57pm

In reply to @tdlee64 "I was recently diagnose with MGUS my M protein is 0.13 I'm scared and trying to..." + (show)

@tdlee64
MGUS only has a 1% per year of progressing.
I have smoldering multiple myeloma & have a 5% chance per year progressing. I've been smoldering for 19 months.
Don't stress too much as most people with MGUS never progress or takes years to move forward to SMM like me

kjoed53 | @kjoed53 | Apr 28 5:43pm

I'm 73 years old and on 22.5mg prednisone for a rheumatologist diagnosis of PMR, but he sent me to a hematologist for interpretation of other unusual blood results. I am now in the process of being diagnosed on the spectrum of MGUS, SMM or MM. This is the blood work and 24 hour urine collection results so far. I had a PET scan yesterday and have a hematologist/oncologist appointment with a bone marrow biopsy scheduled for tomorrow morning.

Immunofixation result, serum = abnormal
M-spike = 0.5
Free Kappa Lt chains, s = 94.1
Kappa/lambda ratio = 10.23

Protein 24 hour calc = 177
Kappa/lambda ratio, u = 19.12
IFE interpretation, u = abnormal
Bence Jones protein positive, kappa type

My serum kappa/lambda ratio has gone from 8.21 to 10.23 in two months. My Free Kappa Lt chains started at 143.7 pre prednisone. I have not gone over any of the latest test results yet with my doctor.

tdlee64 | @tdlee64 | Apr 28 8:38pm

In reply to @sallik74 "@tdlee64 MGUS only has a 1% per year of progressing. I have smoldering multiple myeloma &..." + (show)

@sallik74 thank you❤️

tdlee64 | @tdlee64 | Apr 28 8:42pm

In reply to @amberl99 "@tdlee64 hopefully I can reassure you. This is a low Mspike. Don’t give away your happiness..." + (show)

@amberl99 thank you for the encouragement 🥰

mcgirene | @mcgirene | Apr 29 10:32am

In reply to @kjoed53 "I'm 73 years old and on 22.5mg prednisone for a rheumatologist diagnosis of PMR, but he..." + (show)

@kjoed53 Please let us know what your doctor says.

kayabbott | @kayabbott | Apr 29 11:07am

In reply to @crunchywfwf "Thank you, can you recommend the specific Tumerico’s you take? I have tried dozens over the..." + (show)

@crunchywfwf I use Qunol and Garden of Life brands, but FDA doesn't regulate supplements, so it's anyone's guess as to what brand(s) would be best/not. I always take them with full meals that contain fats (aids absorption partly by slowing it). One can also add turmeric root/powder to foods (I do with curries and granola), but the concentration of the (helpful part) curcuminoids is supposedly less concentrated in the root. .

kjoed53 | @kjoed53 | Apr 29 2:10pm

In reply to @mcgirene "@kjoed53 Please let us know what your doctor says." + (show)

@mcgirene
My hematologist/oncologist is cautiously optimistic that I don't have MM, but has to wait for the scan results, which should be available by the end of the week, and the bone marrow biopsy, which will be available in about 10 days. I go back in two weeks unless I hear otherwise.

DMD81 | @dmdinapoli81 | Apr 30 3:23pm

In reply to @kjoed53 "I'm 73 years old and on 22.5mg prednisone for a rheumatologist diagnosis of PMR, but he..." + (show)

@kjoed53
Hi and welcome to the plasma Cell neoplasm world. Your numbers to me (while not a doctor) are MGUS since your M-Spike is .5, once it gets towards 1.4 I would make sure a BMB is done as a baseline. They will check the involvement of the monoclonal cells, the (CTC) within the bone marrow.

kjoed53 | @kjoed53 | Apr 30 4:09pm

In reply to @dmdinapoli81 "@kjoed53 Hi and welcome to the plasma Cell neoplasm world. Your numbers to me (while not..." + (show)

@dmdinapoli81
My doctor is cautiously optimistic that it's not MM, pending scan and biopsy results. The concerning factors are the rising Kappa lambda ratio, the pressure I feel in my upper left abdomen and the fact that I didn't get full PMR relief with 25mg prednisone and the pain is actually returning in the past week. I'm also severely fatigued even with taking belsomra no matter how much I sleep. My calcium is also moderately high.

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