Has anyone experienced depression after taking praluent?

Whew, so glad it went away @kallettla .
Good thinking to ask your pharmacist. Have you been able to have a conversation with your doctor about your reaction? Maybe they’ve heard of this before, or can help you figure out which thing caused your problems. I agree, anything to help other people not having the problem is a good thing.

For a time, I took 5mg rosuvastatin (generic Crestor) two times a week. My understanding is it is a statin that stays in our bodies 3-4 days so that type of schedule makes sure there’s always some. Fingers crossed your trial run of Crestor goes well!

This scare of anaphylaxis with tingly lips and tongue was your 2nd injection? Did anything happen on your first?

Pins and needles to hear more. 😀

Dear friend, forgive me I just scanning these posts and not reading them word for word. So I may be way off track. But let me tell you what happened to me one year ago. First, the answer is custom compounding medicine without the added preservatives. Okay, so here's what happened. Having had perfect health my 65 years, I ended up in the ER twice with BP climbing over 200+. Then 5 drugs later, it kept escalating and I went into depression. My doctors and family told me to see a shrink, but my research said something different. I've had raging chemical allergies for 2 years now, and they told me to watch out for preservatives in medicines. I never knew how they would make me feel, but I promise you this, with custom compounding of my hypertensive medicine, I am a perfectly normal, functioning, well-adjusted person. I'll stop here because this is a lot to take in. All the best to you. And feel free to ask any questions you wish. All the best, Julie

Checking in, @dlkreps
I want to check in with you to see how you are you doing since last commenting you were headed to a lipid specialist for cholesterol management. You have been working through quite a bit with getting a stent and medication side effects.

I thought of you because we had discussed my experience at Mayo Clinic Statin Intolerance Clinic. I thought you may like to meet @wgr123 who just posted about a recent visit after problems with Repatha. I am not sure if I had told you my experiences were consistent with both Repatha and Praluent.
https://connect.mayoclinic.org/comment/1521558/
My quality of life is improving having addressed my symptoms these past months. It has taken consistent, regular focus and effort on the entire scope of mind, body, spirit to be where I am.

How are you doing? Has any particular thing specifically helped, or caused problems?

I am not sure what kind of stent you had put in, but I had AAA three years ago and have aortic stent. I developed depression a few weeks after surgery and it lasted till six weeks and my surgeon said it's a normal effect of any kind of heart surgery so I would also check with your cardiologist.

I am 61 and have genetically high cholesterol. After developing more plaque and a triple AAA, which was repaired three years ago, I am trying to get my cholesterol down naturally, but it is not working well. My LDL is 190 and my doctor has gotten an approval for the PRAULENT I had a terrible reaction to statins after just 10 days was achy. Everywhere felt my muscles were injured and was kind of bedridden. I am just looking to see what kind of reactions people have had when starting the shot and how much they are seeing at lower their cholesterol by. I eat very little in fact, not enough at 1800 cal. I work out five days a week and it is doing nothing to the cholesterol numbers.Thank you.

@jlharsh sorry for not connecting for a while but life has been busy! I’ve been having some adverse health issues the past few weeks and couldn’t quite figure out what’s ailing me. I’ve not been feeling myself now for the last 3 months and wasn’t sure if it’s heart related, seasonal related or what. I’ve been lacking energy and drive for activities I normally find joy and purpose in. Long story short I saw my general practitioner and they started with blood tests and checked for anemia, thyroid and some of the “low hanging fruit.”They also checked for negative effects from the statin. The results came back with my CK and albumin score being very high! They’ve decided to have me take a 2 week break from the rosuvastatin and take another blood test at the end of the two weeks to see if my levels drop back to normal. All I know is that I’ve felt very bad and that overwhelming wave of fatigue and muscles “screaming” for oxygen! @jlharsh I remember you said that you couldn’t tolerate any statins and are taking some sort of shot every month. Could you refresh my memory and an up to date regimen of what’s working for you? I know you went to a lipid specialist at mayo for guidance.

No worries, @dlkreps. I absolutely understand how time goes by trying to get through poor energy/health challenging times. Finding joy in daily life sounds like an extreme struggle right now and I am glad to hear you are partnering with your general practitioner to figure out why.

I recently learned it takes some time for improvement if statins are the culprit, so it is a good thing you are taking the step now to stop taking rosuvastatin. It is also important to address potential heart and kidney problems in addition to muscles.

The injection that works well for me in Inclisiran (Leqvio). Starting requires an initial shot, then a 2nd in three months, a 3rd in another three months. It is every 6 months after that. I am scheduled for my 7th injection in a couple of weeks.

My cardiologist is at Mayo Clinic MN. He has considerable focus on prevention and their Statin Intolerance Program. From this program they will coordinate with other departments as needed, a tremendous benefit of Mayo Clinic’s integrative approach to improving patient health. I also listened to a recent continuing education podcast with him as a guest discussing statin myopathy (including so much more). From our discussions I think you may find it super valuable.

- Dr Kopecky, Mayo Clinic MN
https://www.mayoclinic.org/biographies/kopecky-stephen-l-m-d/bio-20054286
- Statin Intolerance Clinic MN
https://www.mayoclinic.org/departments-centers/statin-intolerance-service/overview/ovc-20442137
- Mayo Clinic Cardiology Continuing Medical Education Podcast: Statin Myopathy

I absolutely recommend contacting Dr. Kopecky or Statin Intolerance Clinic for guidance. You can pursue an appointment here: http://mayocl.in/1mtmR63

I relate to your experience and would like to continue hearing about your experience. This comment has general information and I am certainly happy to share more as you have questions.

What dose of rosuvastatin have you been taking? You mentioned discontinuing. Are you changing anything else in the meantime, other medications, diet, exercise, etc? Are you experiencing symptoms other than muscles, and has your doctor discussed potential heart or kidney concerns?

@jlharsh thanks for the great information! I’ve been thinking all day about seeking out another cardiologist. It seems that I’m not being heard when I express symptoms from medication or any other general heart related issues. I live in west central Mn. so Rochester Mayo is only a 4 hour drive. I will certainly read the articles in the links and listen to the material you sent me.
I’ve been on 5 mg of rosuvastatin along with 10 mg of ezetimibe. Shortly after I began this new regiment I ended up with a bad case of pneumonia. I felt terrible for 3 months. After that I hadn’t been feeling myself but didn’t attribute it to the statin. Well about a month ago it hit me like a brick and so I had my general practitioner do some blood tests. Like I mentioned in the earlier post my CK and albumin levels were very high. My doctor suggested that I take a two week break from just the rosuvastatin. They want to isolate the meds I’m off so that they can determine which one is affecting me. I will have blood work done again April 30th and see if my levels have changed for the better. I really appreciate the information you gave me. I think I will try to get an appt with Dr. Kopecky at Mayo.

@dlkreps I notice on your bio you are also dealing with cancer. I am not sure what type but do know Dr. Kopecky has personal experience with cancer as well. I look forward to hearing what comes next for you. Please keep me posted.