Myqorzo: has anyone tried this new alternative to Camzyos?

Thanks for your question. I am wondering the same thing I am on CAMZYOS 7.5 and my gradient is still 100 standing with Valsalva and 70 lying down and so my doctor wants me to try it but I’m hesitant and also I’m afraid about the transition. where you have to wash out the Camzyos for four weeks. . My LVOT is 68%.

https://www.myqorzo.com/
https://www.mayoclinic.org/drugs-supplements/aficamten-oral-route/description/drg-80008584
https://www.ajmc.com/view/fda-approves-aficamten-for-obstructive-hypertrophic-cardiomyopathy
Hello @jmr091805 , I posted some links for you to read, one is from the Mayo Clinic.
Aficamten is the newest drug recently approved for treating symptomatic HOCM.
Comparing Camzyos and Aficamten in my rudimentary search, revealed studies showing similar results with a slight advantage going to Aficamten for exercise capacity.

Deciding which treatment plan you embark on is up to you and your treating physician. Being educated about what you have and what your choices are can take away some of the fear surrounding HOCM.

We all know there is no "cure" for HCM/HOCM, but treatments available can reduce the worrisome symptoms and give us back a little more quality in our lives.

I had open heart surgery, and speaking for myself only...I would do it again if I had to. I was not a candidate for Camzyos as it was not available at the time. I'm so grateful for getting my life back.
We are all different, and none of us responds to medications the same way.
Have you discussed this newer drug with your doctor?

@joanallione, I wasn't even aware of a Camzyos washout period. That does sound like it could be quite unpleasant or worse. I'm not preparing to quit Camzyos so long as it keeps working. I'm just trying to keep up with the science. Thanks for sharing your situation and making me aware of the washout period! Good luck.

@karukgirl thank you! which open heart surgery did you have and what can you share that would be helpful to know about it?

@joanallione
What mg are you on? My LVOT gradient is 55 and my cardiologist wants to increase me from 10 mg to 15 mg. Im a little scared of the increase because if the mg is too high it can cause loss of life

@tvickery i’m taking 7.5 at 5 at night and 2 1/2 in the morning…yes death is a significant side effect 😟 but in my discussions with my doctor, he said that they have to put those black box warnings because of the way they did the studies for the drug. They didn’t do it in a certain way that the FDA prefers, i can’t remember the difference now, but the point is that they did do all the testing in another way and as far as I know, they haven’t had any deaths from the use of CAMZYOS. Personally, I would be happy with 55 but it really depends on how you feel like mine is high gradient. It’s really high, but I feel fine. I can climb up pills. I don’t feel limited at all by my HOCM. You might talk to your doctor about adding 2 1/2 instead of another five you can do that and also spreading it out not taking it all at once. I find that better like some in the night usually the larger dose because it can make you drowsy and then the smaller amount in the morning that’s just what I’ve worked out with my doctor.

@karukgirl thanks so much for these links. I will read them.. did you have alcohol ablation surgery or some other kind? I don’t think alcohol ablation is considered open-heart surgery so you must’ve done something else.

@joanallione hello!
I had open heart surgery. Septal/papillary myectomy at the Mayo in Rochester.
Best decision I ever feared making.

I have been taking aficamten (Myqorzo) for a couple of years. I was in the trial. I have had good results.

I am planning on starting aficamten next month. I was on camzyos for 2 years but it would accumulate on me and my EF would drop below 50 so they would stop it. This has happened several times so are hoping this won’t happen with aficamten. Have you experienced and side effects or fatigue like some do with camzyos?