GLP-1 Drugs Causing Arrythmias

Posted by larry @larryst, Dec 23, 2024

My cardiologist suggested I start taking a GLP-1 drug. I have read those could cause arrhythmias (my problem). Has anyone had any experience with GLP-1 drugs ?

Interested in more discussions like this? Go to the Heart Rhythm Conditions Support Group.

peaceandlove1988 | @peaceandlove1988 | Jul 29 12:12pm

In reply to @haley1297 "Did you have to get off zepbound? Did your PVCs go away?" + (show)

I switched from semaglutide to tirzepatide/Zepbound to see if it improved the PVCs/nausea. The nausea and fatigue got so much better but the PVCs got so much worse, so I had to stop. I was getting PVCs basically constantly throughout the day. Every 5-10 beats, sometimes every 1-2 beats, nonstop. Super upsetting because the rest of the side effects basically disappeared and it worked better with the hunger/food noise.

I've experienced PVCs with other things like creatine that don't affect most people, so I think I must have some odd gene that makes me susceptible to them...

haley1297 | @haley1297 | Jul 29 12:47pm

In reply to @peaceandlove1988 "I switched from semaglutide to tirzepatide/Zepbound to see if it improved the PVCs/nausea. The nausea and..." + (show)

So disheartening to heart that! Did the PVCs start right when starting the GLP-1s or over time/certain mg? I’m assuming they were not dangerous just very annoying?

merrychristmas | @merrychristmas | Jul 30 12:13pm

In reply to @haley1297 "Did you have to get off zepbound?" + (show)

Zepbound is a tirzepatide. Is that what she is taking?

swex | @swex | Jul 30 10:15pm

In reply to @haley1297 "Any update??" + (show)

After the episode with AFIB, I had another ablation, utilizing the newer Pulse Field ablation technique. The afib has been gone for 5 months now. I spoke to the cardioligist at Mayo and he said if you want to try the Semaglutide again go ahead. The losing of 15-20 lbs has so many benefits to your health he stated. So I am working my way back up on the dosage of semaglutide and hope that I don't go into AFIB again!!!!
I've been back on it about 4 weeks and keeping myfingers crossed!

snovathompson | @snovathompson | Aug 2 6:28am

In reply to @robinkitchens "I have heard of it. I have been following any group like this for the same..." + (show)

Hello, nearly the same thing happened to my husband this week. He has CHF and has had a defibrillator for 5 years. The defibrillator has never gone off until this week (VT and irregular heartbeat).
He increased his dose last Saturday, and by Wednesday his defibrillator went off three times in 10 hours. He was in the hospital for two days (just brought him home last night). They put him on some meds that are keeping his heart rate in rhythm.
None of his doctors would actually say the drug was possibly the culprit, but it's quite bizarre. However, they did tell him to quit taking it.

ob1fam | @ob1fam | Sep 27 7:36am

In reply to @swex "I started taking semaglutide about 5 months ago. During the last 30 days on semaglutide, GLP-1,..." + (show)

@swex I had a CABG in 2019 and went into full AFib in 2020, had an ablation done and was out of AFib for four years. Dr put me on Ozempic and 8 weeks later I went into AFIB. 2nd ablation done and I was out of AFib. Started back on Ozempic and 6 weeks later went back into full time AFib. 3rd ablation done 6 weeks ago, no AFib and no plans to ever take Ozempic again.

kim12345 | @kim12345 | 9 hours ago

For me, I had my first AFib episode 24 hours after I got my shot. Then had another episode the following week 24 hour after I took my shot of Zepbound. Maybe it was purely coincidence or the Zepbound brought it on. Now I'm on Eliquis and waiting for my cardiologist appointment. Holding off on the Zepbound for now. Super frustrating.

View More View Less

Please sign in or register to post a reply.