GLP-1 Drugs Causing Arrythmias

@jmaz888 what is GLP-1 drops?

Coincidence or not, I only started having more PVC’s when I started Zepbound 3 weeks ago. I am not taking any chances and have decided no more GLP-1 for me.

Interesting that my cardiologist just last week wanted me to start Zepbound (insurance wouldn't cover it and changing plans Jan 1 so decided not to push it further now). This came out of the blue and I was not in favor of it - have many concerns among which is that I am now not in Afib (knock on wood) since having an ablation last February and don't want to rock the boat. I couldn't understand why he wanted me to take this since I am not considered obese just at the beginning overweight range now having lost about 20 lbs in the last year. I asked several times to explain the rationale and the most I can understand is that because I am treated for sleep apnea with a Cpap I would "qualify." My apneas are almost non-existent with Cpap use and I always use it! He says sleep apnea can cause the mild pulmonary hypertension that they say I have but can't find any other cause. But......I don't have apneas with my Cpap use! At any rate, I really don't want to take Zepbound or any of the other GLP-1s.

I thought the GLP-1 drugs were supposed to be BETTER for cardiovascular health, actually benefitting our heart and reducing risk of heart attack, stroke, or death by cardiovascular disease. In recent studies, participants who took semaglutide for more than 3 years lowered their risk of major adverse cardiovascular events by 20%. Wegovy is currently approved for cardiovascular indications in patients with overweight or obesity and existing cardiovascular disease. It's prescribed to improve heart function as a primary benefit.

@carculmer ask Dr why he is suggested it . You can refuse any treatment your Dr suggests

I have been on Mounjaro for 2 1/2 years... 2.5mg for over a year, then switched 5.0mg for another year. I stopped taking it about a month ago. I am not diabetic. I used it for weight loss and it worked great. I am middle-aged woman and always been active. I lost about 55 lbs.

My average resting heart rate at night used to be in the high 50s, low 60s. After first year of Mounjaro, my average HR while sleeping went up to 70. Then over the next year it creeped up to 80. That's an average HR of 80 while sleeping! That's way too high. I tried everything to figure out what was going wrong. Did imaging, bloodtests, exercise stress tests... all the things.

Stopped using Zepbound (switched to that once it was approved) and now after a few weeks of of not using it, my average sleeping HR is back to high 50's, low 60s and maintaining. It was definitely the GLP-1 that made the HR go up and it was significant. Please note that it did not affect my blood pressure at all. That remained stable for 2 years at about 110/70. I am on no other meds. So, that's my experience.

This is a very interesting threat. I just started glp1 Tirzepitide six weeks ago and I’ve lost 31 pounds but my PVCs have been through the roof. No I will say I was already having them before I started the medication but not like I have them now and it seems to come and waves, but the first night after my first shot, it was insane. I thought I was going to die. now overtime they come and go. But the last few days have been hell I went like three weeks with barely any the first three weeks with a lot and now this week number seven has been terrible. My PCP keeps telling me it’s not from the shot, but I don’t know if I’m going to keep taking it.

@kpryor1982 you don't mention what your dose is for the Tirzepitide. Please fill me in. Thanks

I have been taking Ozempic for 6 months with no issues but have recently switch to Mounjaro which has been more effective for most. The GLP type drugs are the most likely to increase HDL and lower triglycerides and that is why they are good for heart health overall.

There are people having problems with the injectable GLP drugs are primarily those injecting into the stomach and not those injecting into an arm or leg.

I have switched most of my heart medications but sticking to the same type, as with the Metoprolol beta blocker that I switched to taking another beta blocker, Bisoprolol. I am switching from the statin rosuvastin to Lipitor as the former has a significant drug to drug interaction with Ticagrelor. I switched to Ticagrelor as Plavix/clopidogrel with rosuvastin increases the AUC by 2.5 fold.

With multiple drugs one is much more dependent on their cardiologist and this unfortunately is not a solution as doctors very seldom in my own experience are sufficiently diligent and tend to hope for the best.

I have needed to spend days doing the research on my own but as my life is important to me the effort is not something I would consider not doing.

@deniseheart I’m on the lowest dose. .5