My experience with zonisamide for seizures (a sulfa drug)

Posted by lsittll @lsittll, Apr 12 10:06pm

I have uncontrolled seizures for 53 years. I have taken almost every medication possible. I almost died from a rare side effect of a newer drug. My doctor is very understanding about this. She has added zonisamide to the Lamcital and Depakote I take. It has done miracles! What once was 6 or 8 seizures monthly is now 1 a month. Zonisamide (a sulfa drug) for seizures?

Hello @lsittll

How wonderful that you found a drug that would help seizures! You must be thrilled after dealing with this disorder for over 50 years. It really is quite amazing that a sulfa drug could help so much.

I found an article on the Epilepsy Foundation website about Zonisamide for those who might be interested in learning more. Here is the link,

Liked by Leonard, lynette1975


I'm tagging fellow members @lady35 @dhramsey @lmcquade and @searching71, who will be interested in your experience with zonisamide (Zonegran),

@lsittll, how long have you been taking the combination of Lamcital, Depakote and zonisamide? Any side effects?


I started taking zonisamide approximately one year ago. It was added to the combination of Depakote and lamotrigine that I had already been taking. I have not had any side effects.

Please login or register to post a reply.