Zometa infusions to help prevent bone loss from cancer treatments

Posted by trixie1313 @trixie1313, Jun 13, 2019

Has anyone had Zometa infusions to help combat the effects of aromatase inhibitors (bone loss). I have osteoporosis of my spine and osteopenia of the hip and am told I need this to prevent future fractures.

@baby99

Have my first infusion on Monday. Since I have reactions to most meds, I have bad fibromyalgia, am a little worried about how sick I will be. Have something important to do on Tuesday and can't be sick. Should I postpone it?

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@baby99, I would ask your oncologist about whether to postpone the Zometa injection or not.

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Hi everyone. I too had become, chemo and radiation and am now on anastrozole. Sorry for the silly question, but what are the infusions you are getting and what are they for?

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@karendb

Hi everyone. I too had become, chemo and radiation and am now on anastrozole. Sorry for the silly question, but what are the infusions you are getting and what are they for?

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Hello Karendb, part of losing your estrogen, from treatment, menopause or both is losing bone density. The zometa infusions are to strengthen your bones. In some cases because we are special we get to lose our estrogen earlier than normal, and more completely. This can cause us to lose bone density younger and need early intervention.

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Thank you for answering so quickly.

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@baby99

Have my first infusion on Monday. Since I have reactions to most meds, I have bad fibromyalgia, am a little worried about how sick I will be. Have something important to do on Tuesday and can't be sick. Should I postpone it?

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Hi @baby99,

I agree with @colleenyoung that you should consult with your oncologist. I also thought you might be interested in this information about zometa and joint pain: https://www.cancer.net/coping-with-cancer/physical-emotional-and-social-effects-cancer/managing-physical-side-effects/joint-pain

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@oilermama

I have Zometa infusions once every three months – in fact I have one in a week. My Dr. at U of M is the one who rewrote the protocol for the Zometa infusion timeline — she (and others) discovered there was no difference in efficacy between once a month and once every three months. Best wishes for this treatment — I have found it to be really easy.

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I will be starting Zometa transfusion on Sept. 3, 2021, (one every 6 months). I have been on Anastropole since 01/4/2021 and am doing fine with that so far. I read that if your transfusion for Zometa is 30 minutes instead of 15 minutes that you may have fewer side effects. What is your experience with the drug. How much should you hydrate before and should you eat before? Thanks so much.

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@omega20

I will be starting Zometa transfusion on Sept. 3, 2021, (one every 6 months). I have been on Anastropole since 01/4/2021 and am doing fine with that so far. I read that if your transfusion for Zometa is 30 minutes instead of 15 minutes that you may have fewer side effects. What is your experience with the drug. How much should you hydrate before and should you eat before? Thanks so much.

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Mine were quickly changed to every 6 months after the first 3 because there was a mistake in the orders. But with no real side effects or issues. My infusions take about 20 minutes, they add a little saline to an IV then do a push of the drug over about 5 minutes then finish the little bag of saline, then I am off to have lunch.
I try and drink an extra big glass of water the day before, and an extra glass the morning of, and an extra glass that night. Eating normally, no nausea involved. I drive an hour and a half to my doctor, so I get to go to my favorite Italian afterwards. Another comment my doctor made is if you are not taking a calcium and D supplement before this to start taking one. I take 600 Ca, plus Vit. D every day. Are taking any calcium supplements?

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@oilermama

I have Zometa infusions once every three months – in fact I have one in a week. My Dr. at U of M is the one who rewrote the protocol for the Zometa infusion timeline — she (and others) discovered there was no difference in efficacy between once a month and once every three months. Best wishes for this treatment — I have found it to be really easy.

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I am scheduled to get Zometa infusion every 6 months. I wonder why the difference especially since your Dr. seems especially knowledgeable. Also do you hydrate before (more than usual).

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@auntieoakley

Mine were quickly changed to every 6 months after the first 3 because there was a mistake in the orders. But with no real side effects or issues. My infusions take about 20 minutes, they add a little saline to an IV then do a push of the drug over about 5 minutes then finish the little bag of saline, then I am off to have lunch.
I try and drink an extra big glass of water the day before, and an extra glass the morning of, and an extra glass that night. Eating normally, no nausea involved. I drive an hour and a half to my doctor, so I get to go to my favorite Italian afterwards. Another comment my doctor made is if you are not taking a calcium and D supplement before this to start taking one. I take 600 Ca, plus Vit. D every day. Are taking any calcium supplements?

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Yes I take Calcium and Vitamin D plus another hair, skin and nails pill which has a little more of each. I hope my doctor will monitor to see if I have enough.

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@omega20

Yes I take Calcium and Vitamin D plus another hair, skin and nails pill which has a little more of each. I hope my doctor will monitor to see if I have enough.

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I am honestly not sure if my doctor really monitors it. But he always asks to make sure I am still taking it. I am not sure about the timing thing every three or six months, other than my doctor always sees my husband and myself one after the other in the same visit, and my husband gets his bone strengthener every three months because he has multiple myeloma.

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@auntieoakley

I receive Zometa every three months, I was 38 when I was originally diagnosed, which resulted in an oopherectomy and a course of tamoxifen. Then eight years later I went on anastrazole. My really great oncologist said it would be prudent to start zometa , I have had two now without incident. I hope it is that easy for you as well.

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I start Zometa next month and then every six months. I am concerned about the dental issues with this drug. My dentist has done a panoramic x-ay and examination. He has said that I am ok to proceed with Zometa. However, what if something comes up. How long can one go without some dental work? Is the not dental work isuue only for the few weeks after Zometa treatment or for3-6 years depending on how long you take it? Very confused with this issue.

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@omega20

I start Zometa next month and then every six months. I am concerned about the dental issues with this drug. My dentist has done a panoramic x-ay and examination. He has said that I am ok to proceed with Zometa. However, what if something comes up. How long can one go without some dental work? Is the not dental work isuue only for the few weeks after Zometa treatment or for3-6 years depending on how long you take it? Very confused with this issue.

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The way I understand this issue is that any dental work that doesn’t impact the jaw is fine. I have had quite a bit of dental work, and so has my husband. But I had a tooth get broken and start dying, that required a root canal. I had not had my infusions during the pandemic and the root canal went fine. Then I had to have that tooth pulled because it started to crumble under the crown. I was very afraid of osteonecrosis of the jaw. But I was about 6 months past due for my infusion and and it is a tiny percentage of people who get this. Everything went fine. I healed normally after a very difficult extraction. I will start my infusions again as soon as it is safe to do so.

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