Why Genetic Testing for Mental Health Meds is Important

Posted by ainsleigh @ainsleigh, Feb 11, 2019

@ainsleigh– Recently we learned that my 19 year old Grandson (who has been diagnosed with depression, panic attacks and anxiety) has not been
on the right medication. In fact the one he has been on was in the red (wrong) zone as opposed to green or yellow. Needless-to-say he is tapering off it in preparation to be put on one in the green zone! We did learn this through the Genetic Testing. If you are able to access this testing I would really recommend it!
Best wishes
Ainsleigh

Has anyone had MTHFR come back on their genetic testing? I paid four figures after insurance a couple years ago when a doctor ran genetic testing (unbeknownst to me) and this is one of the results. It has depression and anxiety linked to it, which runs in my family might explain that. I have an high sensitivity with medications and would definitely like the testing to find out which meds would work best. Roulette wheel scares me to death with each new med. I'm on Lexapro but am having panic attacks that are getting worse. I guess it's time to up my level on it. I've been resisting but this last one scared me.

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@gldnrtrvrlvr Boy I had trouble putting in your code name. I have been on Lexapro and feel good on it, but I'm also on Klonopin, and Lamictal. Ask your doctor about those two meds. The Klonopin is for anxiety and the Lamictal is used for seizures, but is also a mood elevator. I hope this helps you. I am also depressive and anxiety. I haven't had any panic attacks for some time. Mental Illness runs in our family.

Well we leave Saturday for Mayo. I have to have a Covid-10 test and blood test for it. It has to be done 48 hours before surgery, that's all for Sunday. But, Monday I have a 7:30 appointment for a chest x-ray and then an EKG. Later I see the surgeon and then later he does an exam. We also will go to a class which will help my husband know how to help me once I get home. I'm starting to get nervous, but yet excited. I'm not scared of the surgery. I think I'm more scared once we get home. My husband works full-time out of our house as Cyber Security for Wells Fargo. He is so busy now it just scares me how he is going to take care of me. He will find out at that meeting.
I hope you start feeling better, I know what it is like. My son has bipolar 1 and has a hard time, but my mom had that too and ended up ending up her life at the age of 69.

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@ lilypaws

How are you doing? I hope you'll be able to let me know. Virtual hugs to you.💜

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@wsh66

Many of us did use kinetic testing to avoid the hit-and-miss process with psychotropic meds. I think some doctors are insecure having a test tell them what they should prescribe for their patients. You can go to the website and put in your zip code and they will furnish you a list of doctors who will administer the test and explain the results. Then you can take it to your clinic and you are doctor and have it made a part of your permanent medical record. When doctors see these reports they understand that this is something they should be doing because of the wealth of information, page after page after page, detailing how you will metabolize three different classes of drugs is just invaluable.

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Thanks, that's a great idea and may stop a lot of my adverse drug reactions and bad side effects that are occurring. I'm currently trying to reach my Psychiatrist because we agreed that I'd increase my Lexapro to 15 mg. and that's when I realized it was the medicine that's been causing quite a few problems since I went on it almost a year ago and hadn't put the two together. When you have so many medical conditions going, it's harder to determine what is causing what. I looked up the side effects of Lexapro in great detail and found side effects that I've been struggling with. Now to get through to the doc. They won't take a message and I can't find a way to leave a message for her on her website! I'll look one more time then I'll be walking into the office.

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@lilypaws

@gldnrtrvrlvr Boy I had trouble putting in your code name. I have been on Lexapro and feel good on it, but I'm also on Klonopin, and Lamictal. Ask your doctor about those two meds. The Klonopin is for anxiety and the Lamictal is used for seizures, but is also a mood elevator. I hope this helps you. I am also depressive and anxiety. I haven't had any panic attacks for some time. Mental Illness runs in our family.

Well we leave Saturday for Mayo. I have to have a Covid-10 test and blood test for it. It has to be done 48 hours before surgery, that's all for Sunday. But, Monday I have a 7:30 appointment for a chest x-ray and then an EKG. Later I see the surgeon and then later he does an exam. We also will go to a class which will help my husband know how to help me once I get home. I'm starting to get nervous, but yet excited. I'm not scared of the surgery. I think I'm more scared once we get home. My husband works full-time out of our house as Cyber Security for Wells Fargo. He is so busy now it just scares me how he is going to take care of me. He will find out at that meeting.
I hope you start feeling better, I know what it is like. My son has bipolar 1 and has a hard time, but my mom had that too and ended up ending up her life at the age of 69.

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@lilypaws How're you doing? I've read in other parts that your home now. That was quite a surgery. Do they want you up and walking every day? After my fusion, that's what I had to do. My surgery was in 2013. Lately it feels like my screws are poking me and boy does that hurt.

I will talk to my doctor about those meds if I can but you know doctors don't like patients telling them how to do their jobs! Great way to get them grouchy usually or tell you to leave. I understand about the genetic factor of anxiety/depression as both my kids are dealing with depression and anxiety, my father fought depression all his life and committed suicide at 60, my mother fought anxiety and depression. I don't know beyond that. It wasn't talked about. Now they've labeled Gen Z as having both. How is that possible when they've been given everything? Wish they'd grown up like we did where they'd to go outside and play with friends, no TV, social media, phones, etc. to waste away the day with instead of doing something and having chores to do. My kids did have chores and have to play outside but we're still influenced by the technology advances. It was a fight.

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@gldnrtrvrlvr

Has anyone had MTHFR come back on their genetic testing? I paid four figures after insurance a couple years ago when a doctor ran genetic testing (unbeknownst to me) and this is one of the results. It has depression and anxiety linked to it, which runs in my family might explain that. I have an high sensitivity with medications and would definitely like the testing to find out which meds would work best. Roulette wheel scares me to death with each new med. I'm on Lexapro but am having panic attacks that are getting worse. I guess it's time to up my level on it. I've been resisting but this last one scared me.

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Hi @gldnrtrvrlvr — There is another discussion for MTHFR that you may find helpful to meet other members discussing the gene.

Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this: https://connect.mayoclinic.org/discussion/hyperhomocysteinemia-with-mthfr-c677t-mutations-does-anyone-have-this/

Are you able to discuss the meds with your doctor or pharmacist to see if there are better alternatives?

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@gldnrtvrlvr I had Gene sight testing 3 months ago by my psychiatric nurse. I have been dealing with depression for years and I am now 75yo. I failed the test according to my doctor. There is no bad, good or otherwise drug that stands out???? So back to hit and miss. Currently prescribed Vraylor. almost 1 month low dose. I can/will cry anytime, anywhere,

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@summertime4 I empathize with your crying as I do too. It used to be that in doctor office that they'd actually empathize and try to take care of you when this occurred. Now, the front office employees totally ignore you and I even had my neurologist just act like it was another day in the office. It was my worst panic attack to date. 😳

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summertime4 Hello I was in your shoes and I had to up my dose of Prozac to get rid of the Depression and suicidal thoughts. I went to 60. No more thoughts. I am also making myself –pray everyday Sit in Sun 10 minutes take my meds faithfully. I lost 7 lbs. Need to lose 40 more to get where I was fit. I also asked for a separation from having a boyfriend that emotionally abused me. I am also learning about co-dependency. It is changing my whole LIFE too. God Bless you. I still have PTSD and ADHD -working as always on that.

Liked by gldnrtrvrlvr

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@summertime4

@gldnrtvrlvr I had Gene sight testing 3 months ago by my psychiatric nurse. I have been dealing with depression for years and I am now 75yo. I failed the test according to my doctor. There is no bad, good or otherwise drug that stands out???? So back to hit and miss. Currently prescribed Vraylor. almost 1 month low dose. I can/will cry anytime, anywhere,

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I know how you are feeling. I hate the hit & miss with meds. I went off effexor a yr ago, but the last few months I have been soooo down. I will be starting on Lexapo soon, if i can last that long. Sending hugs.

Liked by gldnrtrvrlvr

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Have you had gene profiling done?

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@wandasophia

I know how you are feeling. I hate the hit & miss with meds. I went off effexor a yr ago, but the last few months I have been soooo down. I will be starting on Lexapo soon, if i can last that long. Sending hugs.

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@wandasohia I'm on Lexapro and it really keeps me stable. I'm also on Lamictal 200 MG, which is used for seizures, but is also a mood elevator. I still cry over some things, but feel stable. Hope it works as Well for you and you may want to add Lamictal.

Liked by gldnrtrvrlvr

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@johnbishop

Hi @gldnrtrvrlvr — There is another discussion for MTHFR that you may find helpful to meet other members discussing the gene.

Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this: https://connect.mayoclinic.org/discussion/hyperhomocysteinemia-with-mthfr-c677t-mutations-does-anyone-have-this/

Are you able to discuss the meds with your doctor or pharmacist to see if there are better alternatives?

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Thank you for the MTHFR link as I will definitely go to there. Thanks also for asking about if I've reached my doctor.

I FINALLY, reached my doctor yesterday. She put my side effects from the Lexapro down to my other meds. Actually spent more time addressing my MTHFR and what I need to be taking (more than any other doc has) than my actual request to change my meds. Then concluded that if I really wanted to changed my meds to let her know. The eye side effects (Glaucoma) are pretty serious: curving lines, eye pressure especially when laying down, and a lot of facial twitching. I was cleared by eye doc of any signs of Glaucoma within 6 months before starting Lexapro.
There's several other different side effects. I can definitely pin these side effects to when I started Lexapro. I've been self-weaning off Lexapro and am now down to 5 mg./day. I have never contacted her before about meds and Lexapro manufacturer states that if Glaucoma side effects become present to immediately contact your prescribing physician, which I now have. Nothing's changing yet. I'd rather be on no anxiety/depression meds than to continue with these side effects that can become permanent.

Thank you all for lending your ear/eyes/empathy/knowledge. Have a blessed day. Susan

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@wsh66

Have you had gene profiling done?

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Stephen, I had genetic testing done 5 years ago by a cardiologist for something else so it wasn't a full gene testing. That's how we found the MTHFR genetic mutation. He didn't even mention it to me. I always request a copy of my lab reports and go over them. That's how I found out and took it in took my PCP and discussed it with her. She explained it a little bit was clueless as what to do. A mixing pharmacologist that I just happened to strike up a conversation with has it, so he explained more and that I needed to take supplements. I started researching then.

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@gldnrtrvrlvr

Stephen, I had genetic testing done 5 years ago by a cardiologist for something else so it wasn't a full gene testing. That's how we found the MTHFR genetic mutation. He didn't even mention it to me. I always request a copy of my lab reports and go over them. That's how I found out and took it in took my PCP and discussed it with her. She explained it a little bit was clueless as what to do. A mixing pharmacologist that I just happened to strike up a conversation with has it, so he explained more and that I needed to take supplements. I started researching then.

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@gldnrtrvrlvr Did you start supplements, what kind, did you notice any improvements?

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