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Statins and liver ALT
I am one of the folks with very high CAC score and have been on statins for 5 or 6 years. The doc wanted my target LDL below 70 and the only way to get there was 40mg rosuvastatin along with Zetia, but then my liver ALT climbed up to 62. We adjusted the meds down to 20 mg rosuvastatin and liver ALT is back down to ~50, still slightly above normal. All other liver enzymes are normal. So, we are considering switching me to Repatha, depending on insurance coverage, but not sure my situation is qualifying.
My question is have any of you here had similar liver response to a statin? And is a stable ALT of ~60 really a problem or a no nevermind?
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After a TIA 2.5 years ago I was given Atorvastatin, severe muscle pain at 40 mg, stopped completely for a month, then escalated to 20 mg which I had until October this year, got 3 times as high liver values which is not unusual according to the pharmaceutical company. The muscle pain was severe again, changed doctors. Now 5 mg Rosuvastatin for 8 weeks and then supplemented with Ezetimibe (blocks cholesterol absorption in the liver) 5 mg and feel good after 2 months. New liver test in December but expect higher liver values but are okay to a certain level. Im also a nurse and have fibromuscular dysplasia in the arteries of the brain and mildly in the carotid arteries.
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After 2 years of Atorvastatin, I have switched to a newer statin that is different from other statins, Rosuvastatin and Ezetimibe. For 2 months I had 5 mg Rosvastatin but my blood lipids increased so then I was given 10 mg Ezetimibe which blocks the absorption of cholesterol in the liver, had it for a month. Had Tia and have an artery disease that means I have to have low blood lipids.
No muscle pain or elevated liver values so far, had severe muscle pain with Atorvastatin.