Return to Anti-depressants that Stopped Working

Posted by johnhans @johnhans, Oct 12, 2016

Has anybody tried returning to an anti-depressant that stopped working and then tried to go back to it many years later to see if it would work again? I have been on just about every anti-depressant there is. Some never worked, others gave bad side effects such as Cymbalta, and others stopped working after a while such as sertraline. I was on this many years ago and since I have been on most all anti-depressants, my doctor decided to try sertraline at a higher dose of 150 mg. I have been having trouble with insomnia, but still have depression. It works to a degree, but not enough to take away the fog and tiredness. Of course insomnia can be contributing to that. I am also taking 150 mg of trazodone. I have had depression since a child. Depression and anxiety has run in my family for generations.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

@henrymb

I am BiPolar, take 300mg of lithium (for manic) night, with 100mg of Quetipine, if I am having problem with depression I have 25mg of Quetiping take one if it does not work I add 1 more, to date I have never had to go above175mg, as I am felling better I start cutting back to the 100mg & morning, I am now sleeping 8hrs a night - have done that in years.
Every morning I take 300mg of lithium + 300mg of XL Bupropien. I also take magnanese, CoQ10, and B12.

Jump to this post

I am glad you have found something to work for you. Thank you for your suggestions.

REPLY
@henrymb

I am BiPolar, take 300mg of lithium (for manic) night, with 100mg of Quetipine, if I am having problem with depression I have 25mg of Quetiping take one if it does not work I add 1 more, to date I have never had to go above175mg, as I am felling better I start cutting back to the 100mg & morning, I am now sleeping 8hrs a night - have done that in years.
Every morning I take 300mg of lithium + 300mg of XL Bupropien. I also take magnanese, CoQ10, and B12.

Jump to this post

Welcome to Connect Henry. Thank you for sharing your success story. Sleeping 8 hours a night is one of the best things you can do for your health. So many people have disrupted sleep. It is hard to get or keep mental and physical health on track without good sleep hygiene.

Do you also exercise? What other activities help?

REPLY
@henrymb

I am BiPolar, take 300mg of lithium (for manic) night, with 100mg of Quetipine, if I am having problem with depression I have 25mg of Quetiping take one if it does not work I add 1 more, to date I have never had to go above175mg, as I am felling better I start cutting back to the 100mg & morning, I am now sleeping 8hrs a night - have done that in years.
Every morning I take 300mg of lithium + 300mg of XL Bupropien. I also take magnanese, CoQ10, and B12.

Jump to this post

Yes I go to the local gym do strength training and some Aerobics, try for 5 times a week. On days I do not go to the gym I walk 40 - 60 minutes a day

REPLY

Sounds like you are doing the right thing for your health and well being!

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Happy it's working for you! It's a wonderful machine! If you are on Medicare they will help pay for it and after so many years you own it!

REPLY
@shotsie

I'm just curious. I was treated for depression( CITALOPRAM 20 MG) years ago, and then stopped taking the medication when I didn't seem to need it. I was fine without it for years. It seems that aging and dementia is bringing it back. Should I try it again?

Jump to this post

I would talk to your doctor about what would be best!

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

I never heard of anyone taking Wellbutrin and Prozac together. Is a general practitioner or psychiatrist giving these? I would trust the latter ! Just my opinion!

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Hi! I have had two psychiatrists prescribe generics Prozac and Wellbutrin.<br>Plus i take Lithium! In the past, I took Wellbutrin and Effexor for several<br>years, also prescribed by a third psychiatrist.<br>Best! Cathy<br><br>

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Thank you, sisterGH for pointing that out. I take the generic, but my doc calls it Prozac and I just throw the stuff in my pill box I have a short term memory of maybe 5 minutes so I was not connecting the dots). Are you on a C-PAP machine? i didn't mention it, but I also have spell apea. As weird as it looks, and as awkward as it can sometimes be to use it, it sure helps me get a better night's sleep.

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Hi Cowboy!
Yes, the Wellbutrin and the Prozac are prescribed by my psychiatrist. i've taken it for about 2 years now and it works very well. i am also taking a 3rd med, topiramate, generic for Topamax. It took us about a year to come up with this combination in the amounts I am taking but what a JOY to finally find a combination that WORKS. Long may it last! I've taken other combinations that worked for a time then became much less effective.

And while I'm writing I am going to plug Mayo-Rochester's 2 week, 5 days a week, out-patient depression/bipolar program for anyone who might be interested. I'm not kidding when I say it saved my life. I was having suicidal ideation up the wazoo in spite of meds and therapy 2xs weekly. I have friends in Minneapolis so I had a free place to stay. It's a combination of group therapy, education, games, yoga/exercise, data collection and planning, mindfulness/focus/concentration. At the point I went EVERYTHING had failed me and this was a last ditch effort to save my life.

That was over a year ago. Good-by suicidal ideation, hello to better management of my daily life and FINALLY moving on after a lifetime of depression and the crisis event that nearly ended my life. I cannot recommend this program too highly. It doesn't work for everyone, there were two people in my group that dropped out (interestingly we all knew, the first day, that they would). You need to be screened first. My insurance covered the cost otherwise the cost would be prohibitive. There is lots of info about the program on the Mayo website under I forget what but it shouldn't be too hard to find.

Here's to moving on, living a better happier life! God knows how much we have all suffered and many times continue to suffer, this perfectly awful, stimatizing disease. I've heard people say that wouldn't wish such and so on their worst enemy. Personally, I think depression is the PERFECT disease to wish on your worse enemy. I've had cancer and I'd rather have it again then an uncontrolled depression. No one who hasn't had an uncontrolled depression so bad you can barely get out of bed could possibly this but you all who have been there, and maybe still are, know EXACTLY what i am talking about.

May everyone who is suffering find something that works.
Berit

REPLY
Please sign in or register to post a reply.