Has anybody tried returning to an anti-depressant that stopped working and then tried to go back to it many years later to see if it would work again? I have been on just about every anti-depressant there is. Some never worked, others gave bad side effects such as Cymbalta, and others stopped working after a while such as sertraline. I was on this many years ago and since I have been on most all anti-depressants, my doctor decided to try sertraline at a higher dose of 150 mg. I have been having trouble with insomnia, but still have depression. It works to a degree, but not enough to take away the fog and tiredness. Of course insomnia can be contributing to that. I am also taking 150 mg of trazodone. I have had depression since a child. Depression and anxiety has run in my family for generations.