Return to Anti-depressants that Stopped Working

Posted by johnhans @johnhans, Oct 12, 2016

Has anybody tried returning to an anti-depressant that stopped working and then tried to go back to it many years later to see if it would work again? I have been on just about every anti-depressant there is. Some never worked, others gave bad side effects such as Cymbalta, and others stopped working after a while such as sertraline. I was on this many years ago and since I have been on most all anti-depressants, my doctor decided to try sertraline at a higher dose of 150 mg. I have been having trouble with insomnia, but still have depression. It works to a degree, but not enough to take away the fog and tiredness. Of course insomnia can be contributing to that. I am also taking 150 mg of trazodone. I have had depression since a child. Depression and anxiety has run in my family for generations.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

I'm just curious. I was treated for depression( CITALOPRAM 20 MG) years ago, and then stopped taking the medication when I didn't seem to need it. I was fine without it for years. It seems that aging and dementia is bringing it back. Should I try it again?

REPLY

Yes I was placed on Prozac back in 1993. Being a military spouse as their pharmacies would change from time to time. I was lucky they all worked on me. Just recently I was put back on Prozac and after all these years I'm doing good on it!

REPLY
@shotsie

I'm just curious. I was treated for depression( CITALOPRAM 20 MG) years ago, and then stopped taking the medication when I didn't seem to need it. I was fine without it for years. It seems that aging and dementia is bringing it back. Should I try it again?

Jump to this post

That would be up to you and your doctor. I only asked because I know that some doctors are retrying medication that stopped working in the hopes that after a long period off of it that it would work again. I was interested to see if it had worked for others. My doctor tried re-prescribing sertraline that had stopped working effectively for me. You can always ask your doctor about retaking citalopram and see what your doctor says. Certainly if you are feeling depressed I would suggest talking with your doctor about it.

REPLY
@cowboy1997

Yes I was placed on Prozac back in 1993. Being a military spouse as their pharmacies would change from time to time. I was lucky they all worked on me. Just recently I was put back on Prozac and after all these years I'm doing good on it!

Jump to this post

Thank you for your reply. I am glad that you are getting relief with Prozac. An earlier entry to this discussion also mentioned going back to Prozac and it worked for them. It seems to be a developing theme. I have never been prescribed it. Take care cowboy1997.

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Hi, John, I was reading over your post, and saw you mention your legs jerking at night. I take the Tizanidine I mentioned for RLS - Restless Legs Syndrome and it helps.
Was trying not to cross-post my 'syndromes'.
I hope you get some relief - you don't need that on top of depression.

Also, I've jumped off & back on the Prozac wagon different times over the years.
Best, Susan
@sistergoldenhair

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

I take Wellbutrin ER, generic prozac, and floroxatine (or however it's spelled) and they are all working great together.

However, I'm writing to echo sistergoldenhair's comments about restless legs syndrome. I had a sleep study to see if i had sleep apnea. It turned out that my legs were jerking me awake so often (although i was unaware of this) I never dropped into REM sleep so no matter how long I slept I never got a GOOD night's sleep. I now take generic Miraplex and it has CHANGED MY LIFE. No more problems falling asleep, staying asleep or getting g a good night's sleep. If you have never had a sleep study, you might want to discuss it with your doctor and see what s/he thinks. It's a pain in the you know where to have all those electrodes glued (literally) all over but they are there to monitor your brain and body activity while you sleep (or don't) and diagnosis your problem.

Usually covered by insurance.
Good luck getting to the bottom of your problem.

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Hi, @berit - I saw your post, and had to smile. I went for a sleep study due to restless legs, and they found I also had sleep apnea.
Along w/ the restless legs, they found I had Periodic Limb Movement Disorder, the jerking of legs during sleep that you described. My study was also covered by insurance. P.S. Prozac and fluoxetine are the same drug, one is simply brand name, the other generic, and cheaper. - - Susan
id- @sistergoldenhair

REPLY

I am BiPolar, take 300mg of lithium (for manic) night, with 100mg of Quetipine, if I am having problem with depression I have 25mg of Quetiping take one if it does not work I add 1 more, to date I have never had to go above175mg, as I am felling better I start cutting back to the 100mg & morning, I am now sleeping 8hrs a night - have done that in years.
Every morning I take 300mg of lithium + 300mg of XL Bupropien. I also take magnanese, CoQ10, and B12.

REPLY
@guener

@johnhans, I certainly have sympathy for your sleep issues, as I, too, am plagued with difficulty in getting to sleep and/or sleeping through the night. As I have gotten older, this problem has become more difficult for me, and I just put up with it to a degree; like you, also getting a full night's sleep eventually when my body is too tired. Taking 100 mg of Trazodone will help me get sleepy, but it doesn't necessarily keep me asleep throughout the night, and a higher dose makes me too disoriented when I wake up to use the bathroom. Sometimes reading for an hour will let me go back to sleep, but often though awake I'm too tired to comfortably read. It's a pickle. I have not gone back to an older medication after a long period of time to see if it works, but for me the combination of Abilify with Lexapro seems to be working much better than anything alone in the past. Like you, I was unable to tolerate the side effects for me while taking Cymbalta, just FYI. I wish you as best of a set of outcomes as possible in your treatment and for your sleep. - Jay

Jump to this post

I used to travel and getting to sleep was always tough. I am bipolar, when I get depressed I cannot sleep, the Dr. put me on 100mg of Quetipine, and some 25mg if I rrequire more I 25mg take one then 2, when things settle out I cut back to 100mg.

REPLY
@johnhans

Hi Susan,
Yes we need to keep our hope up. My great-great grandfather spent the last 25 years of his life in a mental hospital with the same thing I have. Now with the advances we have, I am able to live and take care of myself without hospitalization. I was told by a psychiatrist I had years ago that without my meds I would be where my g-g-grandfather was. We can all be thankful for the advances in treatments for depression and anxiety. When I was young all they had were tranquilizers. I do have some chamomile tea bags that I forgot about and you are right about it being a calmative. I'll have to go back to drinking it. I will talk with my doctor about Tizanidine. I do get tight muscles and my legs tend to jerk at night. Thank you for these suggestions.

Thank you for posting for the first time. I am glad that you have found a combination that is working for you. May you continue on in good mental health.

Jump to this post

Was having trouble getting more that 4 hrs sleep a night. The Dr. sent to a sleep clinic, the test said I was having 27 sleep interuptions a night. I purchased a CPAP (Continuous Positive Air Pressure). Best $600 I ever spent.

REPLY
Please sign in or register to post a reply.