Repatha, side effects and what comes next?

Posted by donlynn @donlynn, Mar 14, 2025

Did anyone here have to stop Repatha injections due to side effects?

Interested in more discussions like this? Go to the Heart & Blood Health Support Group.

Profile picture for agb @agb

@ibchispas what you are seeing here, like most other chat boards, are from those people with problems or reactions to the med. What we're not seeing are from those where Repatha or another drug has been successful and without side effects.

I'm also a 70 year old male and just into year 3 with Repatha (along with 20+ years of a statin). No side effects and it's lowered my LDL from 109 down to 17.

I'm watching other's reactions to know what I might see if something shows up later, but so far, all is good.

Jump to this post

@agb same here.
My husband takes his injections now for 2 years, no side effects but you hear a lot of late term side effects, so we try to get rid of Repatha as soon as we can.

REPLY
Profile picture for rainerhans @rainerhans

@agb same here.
My husband takes his injections now for 2 years, no side effects but you hear a lot of late term side effects, so we try to get rid of Repatha as soon as we can.

Jump to this post

@rainerhans I have been on Repatha for 2 1/2 years. It’s done wonders for my cholesterol. I really don’t think there are any a side effects, although I do have side effects from some other meds I take. My brother has been on Repatha for about eight years and was able to get rid of all other cholesterol medications, with no side effects.

REPLY
Profile picture for agb @agb

@ibchispas what you are seeing here, like most other chat boards, are from those people with problems or reactions to the med. What we're not seeing are from those where Repatha or another drug has been successful and without side effects.

I'm also a 70 year old male and just into year 3 with Repatha (along with 20+ years of a statin). No side effects and it's lowered my LDL from 109 down to 17.

I'm watching other's reactions to know what I might see if something shows up later, but so far, all is good.

Jump to this post

@agb thank you! Statins have caused my liver enzymes to rise and my next option is repatha. You have made me feel like I’m not doomed for suffering from this drug or I have a chance. Thank you. I wish more would post that have had good results.

REPLY
Profile picture for ibchispas @ibchispas

70 year old male with 3 stents in March 2025. Calcium score 912. 100% blockage in ramus, 85% in both RCA and LCX. Cardio put me on Repatha after stents because I cannot take statins or red yeast rice or any other med that affects pancreas. Was hospitalized twice for acute pancreatitus after taking statins or others that affect pancreas.
I am obese with a BMI of 31 but at 6'3" and 255 lbs, I'm not what you would consider morbid. I try to exercise by mostly walking 2-3 miles at 18.5 pace and have adopted low carb diet. I take plant sterols, CoQ10, and other heart healthy supplements. I feel pretty good without any observed problems with joints, pain etc. as mentioned in this thread believed to be reactions to Repatha.

So, y'all are scaring me.

Is there something else that will reduce my LDL, boost my HDL, and lower my triglycerides as effectively as Repatha? Repatha brought me from 300 triglycerides and 125 LDL, with HDL at 40 to:
Triglycerides at 125, LDL at 69, and HDL at 50.
Hopefully I won't have any adverse effects long term but I still would like to try something else.
Any viable solutions are welcomed. Thanks all for the info.

Jump to this post

@ibchispas
https://www.nejm.org/doi/full/10.1056/NEJMoa2511778
I appreciate all of the scary posts, even though it becomes a contest between which is scariest-- the cardiac event or the medication.
Repatha is a great drug for some and it sounds like you are one of the lucky ones.
I'm trying to hold out for gene editing.
You might lower your triglycerides with folic acid. It has been dramatic for me, but I'm not able to brag about LDL or HDL or CALC scores.
Best wishes.

REPLY
Profile picture for agb @agb

@ibchispas what you are seeing here, like most other chat boards, are from those people with problems or reactions to the med. What we're not seeing are from those where Repatha or another drug has been successful and without side effects.

I'm also a 70 year old male and just into year 3 with Repatha (along with 20+ years of a statin). No side effects and it's lowered my LDL from 109 down to 17.

I'm watching other's reactions to know what I might see if something shows up later, but so far, all is good.

Jump to this post

@agb Thank you for your support and share. I've been healthy for 67 years and then in March of 2025 BOOM! What I described above occurred and I had to admit that I was mortal afterall 😉
I then realized it wasn't one thing that brought it on, but many years building up slowly and refusal to stop vaping and eat correctly. I guess God decided I needed a wake up call to make a change.
Since we're supposed to be discussing Repatha, I have one question...has anyone experienced weight gain on Repatha or is my keto diet broken. I get into ketosis moderately and seem to be gaining weight instead of losing. HELP please 🙏

REPLY
Profile picture for ibchispas @ibchispas

@agb Thank you for your support and share. I've been healthy for 67 years and then in March of 2025 BOOM! What I described above occurred and I had to admit that I was mortal afterall 😉
I then realized it wasn't one thing that brought it on, but many years building up slowly and refusal to stop vaping and eat correctly. I guess God decided I needed a wake up call to make a change.
Since we're supposed to be discussing Repatha, I have one question...has anyone experienced weight gain on Repatha or is my keto diet broken. I get into ketosis moderately and seem to be gaining weight instead of losing. HELP please 🙏

Jump to this post

@ibchispas I have been on it for 2.5 years, my brother for about 7-8 years, with no weight gain, and no side effects that we feel. His, because of a stroke and mine because of 3 stents in my LAD artery.

REPLY
Please sign in or register to post a reply.