Prolia treatment for osteoporosis

Posted by Veruska @veriska, Mar 7, 2017

I received the results from my bone test and they have recommended I start Prolia. I have read the side effects and I am concerned. Has anyone use this drug and if so what side effects have you experienced. Thank you

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My mother Sobha Ghoshal ( aged 77 years) has taken Bonmax Pth (teriparatide) injection for 2 years for Osteoporosis. But it failed to increase the bone density in the hips and so the risk of hip fracture is still there after completion of 2 years course. The T score in the femur neck right as well as left in the hips did not improve at all from the first BMD Test done on 19.09.2018 although there is drastic improvement of bone density in AP Spine. Please see the chart below.

BMD TEST done on 19.09.2015

BMD Test Done on 18.09.2017

Region

T-Score

Region

T-Score

Femur Neck Left

-2.2

Femur Neck Left

-2.2

Femur Neck Right

-2.1

Femur Left Right

-1.8

AP Spine L1-L4 is 1.007 g/cm2

-2.2

AP Spine L1-L4 is 0.920 g/cm2

-1.4

Doctor has recommended her Prolia injection for at least 5 years for the next course of action. Can Prolia increase the bone density in the hips and reduce the risk of hip fracture? OR should she go for Reclast/Aclasta (Zolendronic Acid) OR ESTROGEN treatment to increase the bone density in hips to reduce hip fracture. Kindly advise what should be the first line medication for her?

REPLY
@smtamt

My mother Sobha Ghoshal ( aged 77 years) has taken Bonmax Pth (teriparatide) injection for 2 years for Osteoporosis. But it failed to increase the bone density in the hips and so the risk of hip fracture is still there after completion of 2 years course. The T score in the femur neck right as well as left in the hips did not improve at all from the first BMD Test done on 19.09.2018 although there is drastic improvement of bone density in AP Spine. Please see the chart below.

BMD TEST done on 19.09.2015

BMD Test Done on 18.09.2017

Region

T-Score

Region

T-Score

Femur Neck Left

-2.2

Femur Neck Left

-2.2

Femur Neck Right

-2.1

Femur Left Right

-1.8

AP Spine L1-L4 is 1.007 g/cm2

-2.2

AP Spine L1-L4 is 0.920 g/cm2

-1.4

Doctor has recommended her Prolia injection for at least 5 years for the next course of action. Can Prolia increase the bone density in the hips and reduce the risk of hip fracture? OR should she go for Reclast/Aclasta (Zolendronic Acid) OR ESTROGEN treatment to increase the bone density in hips to reduce hip fracture. Kindly advise what should be the first line medication for her?

Jump to this post

My rheumatologist is very knowledgeable about drugs as she was a pharmacist before becoming a doctor. I was on teriparatide for two years and saw a large increase in bone density–i believe it usually increases the BMD in the spine more than the hip. I was on reclast for 3-4 years. My doctor then recommended prolia. She said that what she liked was that BMD continued to increase after stopping prolia.

I was diagnosed with severe osteoporosis at the age of 40–most likely due to use of steroid inhalers for my asthma. After 18 years of treatment with fosomax, teriparatide, reclast, and now prolia, I have finally progressed from severe osteoporosis to osteopenia. I am now 58. I am going to continue treatment as I do not want to have a broken hip at the age of 87 as my mother did. This is not a 2-3 year treatment that will fix everything. It's a long journey, and one that I'm willing to take to prevent spine compression fractures.

REPLY
@bonnieh218

@smtamt sorry I don’t know the numbers/details

Jump to this post

Your mother is a victim of rebound fracture of Prolia. By googling I found that Prolia is less effective than bisphosphonates for reducing fractures and increases infection risk. Now Aclasta contains zolendronic acid (sometimes called zolendronate) and it belongs to bisphosphonates group. I think it is more effective than Prolia. Remember to check urea, creatinine before Aclasta injection and also take 1-2 glasses of plain water 1(one) hour before injection.

My mother Sobha Ghoshal has taken Bonmax Pth (teriparatide) injection for 2 years for Osteoporosis. But it failed to increase the bone density in the hips and so the risk of hip fracture is still there after completion of 2 years course. The T-score in the femur neck right as well as left in the hips did not improve at all from the first BMD Test done on 19.09.2018 although there is drastic improvement of bone density in AP Spine. Please see the chart below.

BMD TEST done on 19.09.2015
BMD Test Done on 18.09.2017
  Region
T-Score
Region
T-Score
Femur Neck Left
-2.2
Femur Neck Left
-2.2
Femur Neck Right
-2.1
Femur Left Right
-1.8
AP Spine L1-L4 is 1.007  g/cm2
-2.2
AP Spine L1-L4 is 0.920  g/cm2
-1.4

REPLY
@ritafarmer

My rheumatologist is very knowledgeable about drugs as she was a pharmacist before becoming a doctor. I was on teriparatide for two years and saw a large increase in bone density–i believe it usually increases the BMD in the spine more than the hip. I was on reclast for 3-4 years. My doctor then recommended prolia. She said that what she liked was that BMD continued to increase after stopping prolia.

I was diagnosed with severe osteoporosis at the age of 40–most likely due to use of steroid inhalers for my asthma. After 18 years of treatment with fosomax, teriparatide, reclast, and now prolia, I have finally progressed from severe osteoporosis to osteopenia. I am now 58. I am going to continue treatment as I do not want to have a broken hip at the age of 87 as my mother did. This is not a 2-3 year treatment that will fix everything. It's a long journey, and one that I'm willing to take to prevent spine compression fractures.

Jump to this post

Prolia can cause rebound fracture if you stop prolia altogether. You will have to get addicted to Prolia forever if you do not want to break your bones like pack of cards. By googling I found that Prolia is less effective than bisphosphonates for reducing fractures and increases infection risk. Now Aclasta contains zolendronic acid (sometimes called zolendronate) and it belongs to bisphosphonates group. I think it is more effective than Prolia.

My mother Sobha Ghoshal has taken Bonmax Pth (teriparatide) injection for 2 years for Osteoporosis. But it failed to increase the bone density in the hips and so the risk of hip fracture is still there after completion of 2 years course. The T-score in the femur neck right as well as left in the hips did not improve at all from the first BMD Test done on 19.09.2018 although there is drastic improvement of bone density in AP Spine. Please see the chart below.

BMD TEST done on 19.09.2015
BMD Test Done on 18.09.2017
Region
T-Score
Region
T-Score
Femur Neck Left
-2.2
Femur Neck Left
-2.2
Femur Neck Right
-2.1
Femur Left Right
-1.8
AP Spine L1-L4 is 1.007 g/cm2
-2.2
AP Spine L1-L4 is 0.920 g/cm2
-1.4

REPLY

I have been getting prolia shots twice a year for years. I have not had any side effects from injection s.

REPLY
@user_chf56161a

I have been getting prolia shots twice a year for years. I have not had any side effects from injection s.

Jump to this post

user_chf56161a: Have you seen any positive changes in bone density scores?

REPLY
@ritafarmer

My rheumatologist is very knowledgeable about drugs as she was a pharmacist before becoming a doctor. I was on teriparatide for two years and saw a large increase in bone density–i believe it usually increases the BMD in the spine more than the hip. I was on reclast for 3-4 years. My doctor then recommended prolia. She said that what she liked was that BMD continued to increase after stopping prolia.

I was diagnosed with severe osteoporosis at the age of 40–most likely due to use of steroid inhalers for my asthma. After 18 years of treatment with fosomax, teriparatide, reclast, and now prolia, I have finally progressed from severe osteoporosis to osteopenia. I am now 58. I am going to continue treatment as I do not want to have a broken hip at the age of 87 as my mother did. This is not a 2-3 year treatment that will fix everything. It's a long journey, and one that I'm willing to take to prevent spine compression fractures.

Jump to this post

Thank you for sharing this. So wonderful that you are doing well.

REPLY
@ritafarmer

My rheumatologist is very knowledgeable about drugs as she was a pharmacist before becoming a doctor. I was on teriparatide for two years and saw a large increase in bone density–i believe it usually increases the BMD in the spine more than the hip. I was on reclast for 3-4 years. My doctor then recommended prolia. She said that what she liked was that BMD continued to increase after stopping prolia.

I was diagnosed with severe osteoporosis at the age of 40–most likely due to use of steroid inhalers for my asthma. After 18 years of treatment with fosomax, teriparatide, reclast, and now prolia, I have finally progressed from severe osteoporosis to osteopenia. I am now 58. I am going to continue treatment as I do not want to have a broken hip at the age of 87 as my mother did. This is not a 2-3 year treatment that will fix everything. It's a long journey, and one that I'm willing to take to prevent spine compression fractures.

Jump to this post

Does Prolia leads to rebound fracture in the long run? Can one stop prolia after 5 years or stopping Prolia will again enhance breaking of bones in hips and spine?

REPLY
@user_chf56161a

I have been getting prolia shots twice a year for years. I have not had any side effects from injection s.

Jump to this post

Has it improved bone density in your hips? What is the T-score of femur neck right and femur neck left ?

REPLY
@user_chf56161a

I have been getting prolia shots twice a year for years. I have not had any side effects from injection s.

Jump to this post

I have had three injections, the first in June of 2017 and the third in June of 2018. During the past 14 months, I have experienced debilitating fatigue, joint pain, persistent cough, acid reflux, and now, shockingly, hair loss. And while the dexa scan at one year showed there was an increase in bone density in my hips, there was a significant loss in the spine. Has anyone else experienced any of this? I feel this drug has destroyed my quality of life, and am inclined to stop.

REPLY
@mabel343

I have had three injections, the first in June of 2017 and the third in June of 2018. During the past 14 months, I have experienced debilitating fatigue, joint pain, persistent cough, acid reflux, and now, shockingly, hair loss. And while the dexa scan at one year showed there was an increase in bone density in my hips, there was a significant loss in the spine. Has anyone else experienced any of this? I feel this drug has destroyed my quality of life, and am inclined to stop.

Jump to this post

Are you talking about Prolia? How old are you? what is the T-score of your A P spine and hips?

REPLY

mabel343: Not sure you CAN stop. am reading from others that once you start, to stop causes a lot of problems. Facebook has a great group about osteoporosis with some good info on the different medications.

REPLY
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