Kidney Disease Cure: What's the latest?

Posted by mikek206 @mikek206, Jul 23, 2021

I read An article a few years back saying…A university in California has produced a compound that stops Kidney progression in its Tracks…What Ever Happened to that..? Did some big Pharmacal Company buy it and put it on the shelf for Money…

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@mikek206 Welcome to Mayo Clinic Connect. Gosh, that would be a wonderful thought, stopping kidney disease progression! I certainly understand your concern about pharmaceutical companies trying to head that development off "at the pass". Here's hoping others might recall this article, as I do not.

I am currently Stage 4, at 22% function. It's a daily chore to keep that up as high as possible, controlling blood pressure and stress, plus diet.

While we wait for others to chime in, are you willing to share your kidney disease journey with us?
Ginger

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I remember a mention of research out of California about an artificial kidney that is placed in a backpack for portability. II have located this article dated January 29, 2021 from UCLAHealth that says that "Dr. Kurtz estimates that his team needs another 18 months to refine the technology on the wearable artificial kidney and then will focus on the implantable artificial kidney."
https://connect.uclahealth.org/2021/01/29/artificial-kidney-could-supplant-dialysis-the-decades-old-standard-treatment-for-kidney-failure/
@mikek206, This is quite an amazing and also complicated project. After reading this article, how would you feel about a wearable device?

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@rosemarya

I remember a mention of research out of California about an artificial kidney that is placed in a backpack for portability. II have located this article dated January 29, 2021 from UCLAHealth that says that "Dr. Kurtz estimates that his team needs another 18 months to refine the technology on the wearable artificial kidney and then will focus on the implantable artificial kidney."
https://connect.uclahealth.org/2021/01/29/artificial-kidney-could-supplant-dialysis-the-decades-old-standard-treatment-for-kidney-failure/
@mikek206, This is quite an amazing and also complicated project. After reading this article, how would you feel about a wearable device?

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Well, I would have to see it in action…Sounds better than going 3 times a week for dialysis. Bet some Pharmacal Company will buy it and put it on their back self…these companies are making much too much money to give it up without a fight…

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@gingerw

@mikek206 Welcome to Mayo Clinic Connect. Gosh, that would be a wonderful thought, stopping kidney disease progression! I certainly understand your concern about pharmaceutical companies trying to head that development off "at the pass". Here's hoping others might recall this article, as I do not.

I am currently Stage 4, at 22% function. It's a daily chore to keep that up as high as possible, controlling blood pressure and stress, plus diet.

While we wait for others to chime in, are you willing to share your kidney disease journey with us?
Ginger

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Well, I have Kidney disease since 2001…went through 2 doctors…All they know is telling you you have to think about Dialysis…I did tell them No…I'm at 15% and it seems to be holding at that… feel fine with no problems as yet…No high blood pressure & no diabetes.. got this problem from dehydration…funny all these years and nobody has anything for this…Very Funny…

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@mikek206

Well, I have Kidney disease since 2001…went through 2 doctors…All they know is telling you you have to think about Dialysis…I did tell them No…I'm at 15% and it seems to be holding at that… feel fine with no problems as yet…No high blood pressure & no diabetes.. got this problem from dehydration…funny all these years and nobody has anything for this…Very Funny…

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Hi Mike, I'm not sure what article you may have read a while back. I know that researchers are working hard to find alternatives for kidney disease from prevention to slowing progression to an artificial kidney and regeneration. It's important to keep in mind that the media often reports on promising medical breakthroughs when the research is still in the early stages. It is likely that the study you read about in still being investigated.

Has your doctor or nephrologist talked to you about diet and lifestyle approaches to slowly the progression of kidney disease?

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Hi Collen…The Article Reads- New Compound Stops Progressive Kidney Disease In Its Tracks…From MIT, Harvard, Brigham & Women's Hospital, and Harvard Medical School describes a new approach…What I Want to know is what Pharmacal Company Sponsor's these Schools and why they did not Market This Coumpond…? This was published by science daily.com … To Much Money To Loose If A Cure Is Found…?

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@mikek206

Hi Collen…The Article Reads- New Compound Stops Progressive Kidney Disease In Its Tracks…From MIT, Harvard, Brigham & Women's Hospital, and Harvard Medical School describes a new approach…What I Want to know is what Pharmacal Company Sponsor's these Schools and why they did not Market This Coumpond…? This was published by science daily.com … To Much Money To Loose If A Cure Is Found…?

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Hi Mike @mikek206 and @colleenyoung – Here is the article source referenced on ScienceDaily.com on December 7, 2017 from the Broad Institute of MIT and Harvard – New compound stops progressive kidney disease in its tracks: https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks

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@johnbishop

Hi Mike @mikek206 and @colleenyoung – Here is the article source referenced on ScienceDaily.com on December 7, 2017 from the Broad Institute of MIT and Harvard – New compound stops progressive kidney disease in its tracks: https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks

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@johnbishop @mike206 Also, here is a meaty article from the National Library on Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014699/

It appears the Compound AC1903 and TRPC5 are dealing with podocytes, an issue with FSGS patients. Not all kidney disease patients have this complication. It seems to me it would be critical to establish the exact cause of a patient's CKD in order to benefit from this therapy. Using my case as an example, my glomeruli [filtering components] are being shut down by collagen Type III building up within them. I have extremely high protein leak into my urine and blood as a result. I don't think this therapy of AC1903 would work, for me.

I applaud any advancements in treatment of CKD! We have often heard, "There is no cure for kidney disease." Even dialysis or transplant is simply a treatment, not a cure."
Ginger

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@gingerw

@johnbishop @mike206 Also, here is a meaty article from the National Library on Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014699/

It appears the Compound AC1903 and TRPC5 are dealing with podocytes, an issue with FSGS patients. Not all kidney disease patients have this complication. It seems to me it would be critical to establish the exact cause of a patient's CKD in order to benefit from this therapy. Using my case as an example, my glomeruli [filtering components] are being shut down by collagen Type III building up within them. I have extremely high protein leak into my urine and blood as a result. I don't think this therapy of AC1903 would work, for me.

I applaud any advancements in treatment of CKD! We have often heard, "There is no cure for kidney disease." Even dialysis or transplant is simply a treatment, not a cure."
Ginger

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Thanks, Ginger…What I Really Want To Know is where all this money going…it's not for any cures or treatment of any kind…seems like the only thing they want is not A Cure but only treatments…no money in a cure…

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@johnbishop

Hi Mike @mikek206 and @colleenyoung – Here is the article source referenced on ScienceDaily.com on December 7, 2017 from the Broad Institute of MIT and Harvard – New compound stops progressive kidney disease in its tracks: https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks

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Thanks, John…That's the one…some big Pharmaceutical Company has that info in a file cabinet somewhere…they don't want to cure anything…(no Money in it) all they are looking for are treatments to keep us coming back for more…Pop a Pill every days…keep them coming back…!

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@mikek206

Thanks, John…That's the one…some big Pharmaceutical Company has that info in a file cabinet somewhere…they don't want to cure anything…(no Money in it) all they are looking for are treatments to keep us coming back for more…Pop a Pill every days…keep them coming back…!

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@mikek206 I wouldn't be so quick to assume that someone is purposefully hiding a cure. Researchers work hard to find treatments that work. As I mentioned earlier, we hear about the promise of potential treatments in traditional media when research is in its earliest stages. Furthermore, the media like to use misleading headlines that proclaim a cure.

Note that in the article to which you refer (https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks), the research to date has only been done on animals. In this case, rats. In other words, very early in the research process.

It takes years for a treatment to get through all the stages of clinical trials and then approval for use. It is frequently stated that it takes an average of 17 years for research evidence to reach clinical practice. Many promising treatments fail when progressing from animal trials to human trials, and researchers have to go back to the drawing board, so to speak.

I look forward to seeing the development of this promising trial. But please note that it is NOT a cure, but has the potential to slow the progression of some types of kidney disease.

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@colleenyoung

@mikek206 I wouldn't be so quick to assume that someone is purposefully hiding a cure. Researchers work hard to find treatments that work. As I mentioned earlier, we hear about the promise of potential treatments in traditional media when research is in its earliest stages. Furthermore, the media like to use misleading headlines that proclaim a cure.

Note that in the article to which you refer (https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks), the research to date has only been done on animals. In this case, rats. In other words, very early in the research process.

It takes years for a treatment to get through all the stages of clinical trials and then approval for use. It is frequently stated that it takes an average of 17 years for research evidence to reach clinical practice. Many promising treatments fail when progressing from animal trials to human trials, and researchers have to go back to the drawing board, so to speak.

I look forward to seeing the development of this promising trial. But please note that it is NOT a cure, but has the potential to slow the progression of some types of kidney disease.

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I know this is not a cure…If it was it would never hit the Market…That's How much trust I have in Big Pharmaceutical Companies…

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