Kidney Disease Cure: What's the latest?

@mikek206 Welcome to Mayo Clinic Connect. Gosh, that would be a wonderful thought, stopping kidney disease progression! I certainly understand your concern about pharmaceutical companies trying to head that development off "at the pass". Here's hoping others might recall this article, as I do not.

I am currently Stage 4, at 22% function. It's a daily chore to keep that up as high as possible, controlling blood pressure and stress, plus diet.

While we wait for others to chime in, are you willing to share your kidney disease journey with us?
Ginger

I remember a mention of research out of California about an artificial kidney that is placed in a backpack for portability. II have located this article dated January 29, 2021 from UCLAHealth that says that "Dr. Kurtz estimates that his team needs another 18 months to refine the technology on the wearable artificial kidney and then will focus on the implantable artificial kidney."
https://connect.uclahealth.org/2021/01/29/artificial-kidney-could-supplant-dialysis-the-decades-old-standard-treatment-for-kidney-failure/
@mikek206, This is quite an amazing and also complicated project. After reading this article, how would you feel about a wearable device?

Well, I would have to see it in action...Sounds better than going 3 times a week for dialysis. Bet some Pharmacal Company will buy it and put it on their back self...these companies are making much too much money to give it up without a fight...

Well, I have Kidney disease since 2001...went through 2 doctors...All they know is telling you you have to think about Dialysis...I did tell them No...I'm at 15% and it seems to be holding at that... feel fine with no problems as yet...No high blood pressure & no diabetes.. got this problem from dehydration...funny all these years and nobody has anything for this...Very Funny...

Hi Mike, I'm not sure what article you may have read a while back. I know that researchers are working hard to find alternatives for kidney disease from prevention to slowing progression to an artificial kidney and regeneration. It's important to keep in mind that the media often reports on promising medical breakthroughs when the research is still in the early stages. It is likely that the study you read about in still being investigated.

Has your doctor or nephrologist talked to you about diet and lifestyle approaches to slowly the progression of kidney disease?

Hi Collen...The Article Reads- New Compound Stops Progressive Kidney Disease In Its Tracks...From MIT, Harvard, Brigham & Women's Hospital, and Harvard Medical School describes a new approach...What I Want to know is what Pharmacal Company Sponsor's these Schools and why they did not Market This Coumpond...? This was published by science daily.com ... To Much Money To Loose If A Cure Is Found...?

Hi Mike @mikek206 and @colleenyoung - Here is the article source referenced on ScienceDaily.com on December 7, 2017 from the Broad Institute of MIT and Harvard - New compound stops progressive kidney disease in its tracks: https://www.broadinstitute.org/news/new-compound-stops-progressive-kidney-disease-its-tracks

@johnbishop @mike206 Also, here is a meaty article from the National Library on Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014699/

It appears the Compound AC1903 and TRPC5 are dealing with podocytes, an issue with FSGS patients. Not all kidney disease patients have this complication. It seems to me it would be critical to establish the exact cause of a patient's CKD in order to benefit from this therapy. Using my case as an example, my glomeruli [filtering components] are being shut down by collagen Type III building up within them. I have extremely high protein leak into my urine and blood as a result. I don't think this therapy of AC1903 would work, for me.

I applaud any advancements in treatment of CKD! We have often heard, "There is no cure for kidney disease." Even dialysis or transplant is simply a treatment, not a cure."
Ginger

Thanks, Ginger...What I Really Want To Know is where all this money going...it's not for any cures or treatment of any kind...seems like the only thing they want is not A Cure but only treatments...no money in a cure...

Thanks, John...That's the one...some big Pharmaceutical Company has that info in a file cabinet somewhere...they don't want to cure anything...(no Money in it) all they are looking for are treatments to keep us coming back for more...Pop a Pill every days...keep them coming back...!