Do Prolia injections affect the kidneys?

Posted by spiritbird2 @spiritbird2, Mar 30, 2016

I have been on Prolia injections for 2 years now. My kidneys were being effected by a lowering of GFR to 45. I am now on a years vacation from Prolia and GFR has increased to 50. My doctor said Prolia does not effect the kidneys. So now I am confused.

Hi @spiritbird2, and welcome to Connect. I’m Alyse, and I’m one of the community moderators here. I found some information on Prolia from Mayo Clinic that you may find helpful (http://www.mayoclinic.org/drugs-supplements/denosumab-subcutaneous-route/description/drg-20074315).

Have you talked with your pharmacist regarding the increase in your GFR? I’m also tagging @nancymc who wrote about Prolia and may have some suggestions or advice for you.

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Any input yet for my Prolia question?

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@spiritbird2

Any input yet for my Prolia question?

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No not yet. Thanks for asking

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@spiritbird2, my mom gets Prolia shots every 6 months. It has helped her mobility enormously. Luckily she hasn’t noticed any decline in kidney function or any other side effect. I also don’t see renal function or kidney function listed as side effects on the link Alyse provided.

I, too, would be confused if my doctor took me off a drug due to a side effect and then said the drug didn’t cause that side effect. I would go back and ask more questions.

What were you taking Prolia for?

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@spiritbird2, we took your question to a pharmacist here at Mayo Clinic. She told us this:

Kidney function decline is not an adverse reaction that is listed in drug references for Prolia. However, this medication can cause a decrease in calcium (hypocalcemia), sometimes severely. The risk is greater with decreased kidney function, and health care providers are advised to use cautiously in these cases. It’s possible that the medicine didn’t cause the decrease in kidney function, but with a decreasing GFR, the doctor may be concerned that it puts you at greater risk for some of the more serious side effects of the medication.

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Thank you so much. My doc does draw serum for electrolytes and Vit D within 2 weeks of Prolia injection. My calcium is usually around 9.4 in that area and do supplement both ca and Vit D. One more question If you had stage 2 or 3 kidney disease and osteoporosis which medication would you take? Thanks again

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I have been taking Fosamax for six month but stopped last month due to stomach upset issues. My doctor ordered Prolia injections twice a year. Upon picking up the prescription and reading the side effects pamphlet, I became worried that the cure may be worse then the disease. I also take bone-up brand cacium supplement 1000 mg calcium plus 500 mg magnesium and strontium 750 mg as well as vitamin D3 1000 iu. I have the ProLia in the refrigerator and an appointment tomorrow with my doctor to inject. I am very concerned about this as I have had a bad reaction to a flu shot four years ago and developed ADEM acute diseminated encephomyilitis. Does anyone have advice I could use?

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I have been on Prolia for about 8 years. About a year ago I developed kidney disease picked up on routine visit and blood work done at the hematology/ oncology office I have been going to and where I received Prolia. My creatinine was 3, BUN was 50 and GFR 17. I was sent to a nephrologist and no one could tell me what caused the dramatic increase in my numbers. Prior my creatinine had been 1.4-1.6 labeled as insufficient kidney function minor now I am told I have stage 3-4 kidney disease. I have done a lot of research as I am someone who needs answers and yes kidney disease is not listed as a side effect of Prolia HOWEVER there are studies that show Prolia can cause a SIGNIFICANT increase in PTH levels ,,,, and high PTH over time can cause kidney disease !, PTH is not commonly tested nor was it at my hematologist, The kidney doctor does it as part of his standard panel and when it was over 900 thought that it was lab error but it came back high on the repeated test as well . My own research led me to Prolia as a reason for the PTH and in the 6 months it decreased to 190 I did not take one again until I have more information. If this has been happening every 6 mos for 8 years I have to wonder if this was the cause of my sudden decline in kidney function ………….

If anyone has had any similar issue please respond,! It is not a link easily made took a lot of looking at different research and articles I do believe this is something that should be mentioned in the Prolia literature but is not !!!!

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@cares I have no experience with Prolia. I do have stage 3 kidney disease (I believe from taking NSAID) so have to watch what meds I am taking. I’m not dealing with liver issues from Tylenol.
I had some bad side effects from a med that were not listed in their literature. My doctor told me I could report my side effects to the FDA and help to get them included in that med literature. If you’d like to do that you can report online here: http://www.fda.gov/medwatch/report.htm or you can call 1-800-332-1088. It’s a small thing but if everyone did that, those small things might result in big changes. Just a thought. Have a great day.

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@bonnieh218

@cares I have no experience with Prolia. I do have stage 3 kidney disease (I believe from taking NSAID) so have to watch what meds I am taking. I’m not dealing with liver issues from Tylenol.
I had some bad side effects from a med that were not listed in their literature. My doctor told me I could report my side effects to the FDA and help to get them included in that med literature. If you’d like to do that you can report online here: http://www.fda.gov/medwatch/report.htm or you can call 1-800-332-1088. It’s a small thing but if everyone did that, those small things might result in big changes. Just a thought. Have a great day.

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I meant to say I am dealing with liver issues from Tylenol.

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@cares

I have been on Prolia for about 8 years. About a year ago I developed kidney disease picked up on routine visit and blood work done at the hematology/ oncology office I have been going to and where I received Prolia. My creatinine was 3, BUN was 50 and GFR 17. I was sent to a nephrologist and no one could tell me what caused the dramatic increase in my numbers. Prior my creatinine had been 1.4-1.6 labeled as insufficient kidney function minor now I am told I have stage 3-4 kidney disease. I have done a lot of research as I am someone who needs answers and yes kidney disease is not listed as a side effect of Prolia HOWEVER there are studies that show Prolia can cause a SIGNIFICANT increase in PTH levels ,,,, and high PTH over time can cause kidney disease !, PTH is not commonly tested nor was it at my hematologist, The kidney doctor does it as part of his standard panel and when it was over 900 thought that it was lab error but it came back high on the repeated test as well . My own research led me to Prolia as a reason for the PTH and in the 6 months it decreased to 190 I did not take one again until I have more information. If this has been happening every 6 mos for 8 years I have to wonder if this was the cause of my sudden decline in kidney function ………….

If anyone has had any similar issue please respond,! It is not a link easily made took a lot of looking at different research and articles I do believe this is something that should be mentioned in the Prolia literature but is not !!!!

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Hi cares, prior to my first Prolia injection, my GFR was 83.5…..Now 6 months later my GFR IS 71.5…..Mt PTH were 101.4 and 88.4..I have had VITAMIN D megadoses too as my D WAS very low and symptomatic…Curious to how low my next GFR will be in Sept…..I MAY NOT RECEIVE ANYMORE PROLIA OF MY OWN VOLITION, but the elevated PTH IS OF GREAT CONCERN TOO… No one seems to make a correlation to decrease in GFR AND PROLIA….I am just a retired director of nursing….My osteoporosis is moderate to severe…. I think more studies are needed…Our health is suffering here

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@trinity

Hi cares, prior to my first Prolia injection, my GFR was 83.5…..Now 6 months later my GFR IS 71.5…..Mt PTH were 101.4 and 88.4..I have had VITAMIN D megadoses too as my D WAS very low and symptomatic…Curious to how low my next GFR will be in Sept…..I MAY NOT RECEIVE ANYMORE PROLIA OF MY OWN VOLITION, but the elevated PTH IS OF GREAT CONCERN TOO… No one seems to make a correlation to decrease in GFR AND PROLIA….I am just a retired director of nursing….My osteoporosis is moderate to severe…. I think more studies are needed…Our health is suffering here

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Hello @trinity and welcome to Mayo Connect.

I appreciate you sharing your experience with Prolia injections. I can understand your concern with the increase of PTH since the injection. Was your PTH elevated prior to beginning the Prolia treatment? Do you recall what your calcium score was? (PTH and calcium levels are usually taken at the same time).

I also have bone loss, elevated PTH and low levels of D. It all seems to work together.

You mention taking mega doses of Vitamin D. Is this the prescription strength Vitamin D or supplements that you take?

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@bonnieh218

@cares I have no experience with Prolia. I do have stage 3 kidney disease (I believe from taking NSAID) so have to watch what meds I am taking. I’m not dealing with liver issues from Tylenol.
I had some bad side effects from a med that were not listed in their literature. My doctor told me I could report my side effects to the FDA and help to get them included in that med literature. If you’d like to do that you can report online here: http://www.fda.gov/medwatch/report.htm or you can call 1-800-332-1088. It’s a small thing but if everyone did that, those small things might result in big changes. Just a thought. Have a great day.

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Hello @bonnieh218,

I appreciate your sharing information about reporting side-effects of the Prolia treatment. It is a small thing, but if everyone did so, it might make a difference.

Do you mind sharing what med you were taking that caused the side-effects that were not listed in the literature?

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Hopeful33250 I was taking Omeprazole and my doctor said that the side effects I was having couldn’t be from the Omeprazole because the things I was experiencing were not listed as side effects in the Omeprazole literature.

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@hopeful33250

Hello @trinity and welcome to Mayo Connect.

I appreciate you sharing your experience with Prolia injections. I can understand your concern with the increase of PTH since the injection. Was your PTH elevated prior to beginning the Prolia treatment? Do you recall what your calcium score was? (PTH and calcium levels are usually taken at the same time).

I also have bone loss, elevated PTH and low levels of D. It all seems to work together.

You mention taking mega doses of Vitamin D. Is this the prescription strength Vitamin D or supplements that you take?

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Yes, my PTH WAS ELEVATED prior to my first injection and D was very low, calcium was normal….I assumed my parathyroid was producing more in compensation…Yes, prescription strength D3…Also at that time my GFR WAS 83.5….Six months later calcium still normal, PTH STILL HIGH and GFR dropped 12 points…I am concerned about my kidney function….Every other lab is nprmal…I think prolia may be the culprit for the decrease in GFR….As for the parathyroid I am stumped…Rheumatologist plans on checking PTH AND GFR IN A FEW WEEKS. IF my results are not favorable, I may not continue with Prolia…As for the elevated PTH, TUMOR??I think more tests are needed..The b vitamin D deficiency has been ongoing…When you live in the armpit of PA where the sun doesn't shine, lol..

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